WDR64_HUMAN
ID WDR64_HUMAN Reviewed; 1081 AA.
AC B1ANS9; B1ANT0; Q7Z573; Q96LY9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=WD repeat-containing protein 64;
GN Name=WDR64;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
RA Shan Y.X., Yu L.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B1ANS9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B1ANS9-2; Sequence=VSP_033509;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP92796.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB71525.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL365366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX322532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY327404; AAP92796.1; ALT_INIT; mRNA.
DR EMBL; AK057540; BAB71525.1; ALT_INIT; mRNA.
DR RefSeq; NP_653226.4; NM_144625.4.
DR AlphaFoldDB; B1ANS9; -.
DR BioGRID; 126090; 1.
DR STRING; 9606.ENSP00000355510; -.
DR iPTMnet; B1ANS9; -.
DR PhosphoSitePlus; B1ANS9; -.
DR BioMuta; WDR64; -.
DR EPD; B1ANS9; -.
DR MassIVE; B1ANS9; -.
DR PaxDb; B1ANS9; -.
DR PeptideAtlas; B1ANS9; -.
DR PRIDE; B1ANS9; -.
DR ProteomicsDB; 3269; -. [B1ANS9-1]
DR ProteomicsDB; 3270; -. [B1ANS9-2]
DR Antibodypedia; 52507; 41 antibodies from 12 providers.
DR DNASU; 128025; -.
DR Ensembl; ENST00000366552.6; ENSP00000355510.2; ENSG00000162843.18. [B1ANS9-1]
DR UCSC; uc001hzg.3; human. [B1ANS9-1]
DR GeneCards; WDR64; -.
DR HGNC; HGNC:26570; WDR64.
DR HPA; ENSG00000162843; Tissue enriched (testis).
DR neXtProt; NX_B1ANS9; -.
DR OpenTargets; ENSG00000162843; -.
DR PharmGKB; PA142670597; -.
DR VEuPathDB; HostDB:ENSG00000162843; -.
DR eggNOG; KOG0281; Eukaryota.
DR eggNOG; KOG0642; Eukaryota.
DR GeneTree; ENSGT00940000160037; -.
DR HOGENOM; CLU_011653_2_0_1; -.
DR InParanoid; B1ANS9; -.
DR OMA; QPVDKKH; -.
DR OrthoDB; 774295at2759; -.
DR PhylomeDB; B1ANS9; -.
DR TreeFam; TF324700; -.
DR PathwayCommons; B1ANS9; -.
DR SignaLink; B1ANS9; -.
DR BioGRID-ORCS; 128025; 5 hits in 207 CRISPR screens.
DR ChiTaRS; WDR64; human.
DR GenomeRNAi; 128025; -.
DR Pharos; B1ANS9; Tdark.
DR PRO; PR:B1ANS9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; B1ANS9; protein.
DR Bgee; ENSG00000162843; Expressed in buccal mucosa cell and 83 other tissues.
DR ExpressionAtlas; B1ANS9; baseline and differential.
DR Genevisible; B1ANS9; HS.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1081
FT /note="WD repeat-containing protein 64"
FT /id="PRO_0000333256"
FT REPEAT 102..152
FT /note="WD 1"
FT REPEAT 153..198
FT /note="WD 2"
FT REPEAT 199..265
FT /note="WD 3"
FT REPEAT 266..314
FT /note="WD 4"
FT REPEAT 315..356
FT /note="WD 5"
FT REPEAT 357..400
FT /note="WD 6"
FT REPEAT 401..444
FT /note="WD 7"
FT REPEAT 445..488
FT /note="WD 8"
FT REPEAT 489..532
FT /note="WD 9"
FT REPEAT 533..631
FT /note="WD 10"
FT REPEAT 632..740
FT /note="WD 11"
FT REPEAT 741..803
FT /note="WD 12"
FT REPEAT 804..857
FT /note="WD 13"
FT REPEAT 858..895
FT /note="WD 14"
FT REGION 726..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 669..835
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_033509"
FT VARIANT 647
FT /note="R -> Q (in dbSNP:rs12095445)"
FT /id="VAR_043138"
FT VARIANT 952
FT /note="R -> W (in dbSNP:rs12074374)"
FT /id="VAR_043139"
FT CONFLICT 699
FT /note="P -> S (in Ref. 3; BAB71525)"
FT /evidence="ECO:0000305"
FT CONFLICT 1055..1056
FT /note="AP -> VT (in Ref. 2; AAP92796)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1081 AA; 123631 MW; 2F497F01C44D3202 CRC64;
MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA IGYDKFYASV
QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE EDPIASQLDE ENLVFFVSRK
RRILISGSRR RDVIKSIVKI PHLDLLITAT QKGLITVFNN QDTSWITGCD YLLQLKRIVA
TTERTIIVWD YKAQGSSQEN YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF
TVNSDDFGIK QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN
HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW HPNISTKPVG
KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL LQVFHDSQGG PGDMQIYSMI
YDANHGMLIT GSSVMDMYPL TRMIQDTKQV PHTHEREINV MLYNKYFHQV LTICSESIIR
VWELETGLQV YQILEPHGFN TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE
GKDWKEDEHC LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF
LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC IDLLQVEGYN
LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK HFKINDILFL FRTPECARRS
SQDSICSSSQ CESSKGPQSS KGSKQSIHDS EVKGEQTDVM VGKQQPMDKK HPGIANLPEA
QPPILVTAHE DGHLRLWTLE GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI
LCNISSFLDP PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH
YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF DREKWRKMSS
VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT ENREAGIVFG SLPIYSISSP
TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV QREKAPRRRS LKKNLVPQIN LASSFFPAIP
K