WDR64_MOUSE
ID WDR64_MOUSE Reviewed; 1086 AA.
AC Q9D565; Q9CUP8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=WD repeat-containing protein 64;
GN Name=Wdr64;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 442-1086 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 456-951 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D565-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D565-2; Sequence=VSP_033511, VSP_033512;
CC Name=3;
CC IsoId=Q9D565-3; Sequence=VSP_033510;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29725.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB29958.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC122854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK015153; BAB29725.1; ALT_FRAME; mRNA.
DR EMBL; AK015753; BAB29958.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; Q9D565; -.
DR STRING; 10090.ENSMUSP00000128678; -.
DR iPTMnet; Q9D565; -.
DR PhosphoSitePlus; Q9D565; -.
DR PaxDb; Q9D565; -.
DR PRIDE; Q9D565; -.
DR ProteomicsDB; 297895; -. [Q9D565-1]
DR ProteomicsDB; 297896; -. [Q9D565-2]
DR ProteomicsDB; 297897; -. [Q9D565-3]
DR Antibodypedia; 52507; 41 antibodies from 12 providers.
DR Ensembl; ENSMUST00000171939; ENSMUSP00000128678; ENSMUSG00000026523. [Q9D565-1]
DR MGI; MGI:1923070; Wdr64.
DR VEuPathDB; HostDB:ENSMUSG00000026523; -.
DR eggNOG; KOG0281; Eukaryota.
DR eggNOG; KOG0642; Eukaryota.
DR GeneTree; ENSGT00940000160037; -.
DR InParanoid; Q9D565; -.
DR PhylomeDB; Q9D565; -.
DR TreeFam; TF324700; -.
DR ChiTaRS; Wdr64; mouse.
DR PRO; PR:Q9D565; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D565; protein.
DR Bgee; ENSMUSG00000026523; Expressed in seminiferous tubule of testis and 11 other tissues.
DR ExpressionAtlas; Q9D565; baseline and differential.
DR Genevisible; Q9D565; MM.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1086
FT /note="WD repeat-containing protein 64"
FT /id="PRO_0000333257"
FT REPEAT 129..168
FT /note="WD 1"
FT REPEAT 170..199
FT /note="WD 2"
FT REPEAT 321..360
FT /note="WD 3"
FT REPEAT 364..403
FT /note="WD 4"
FT REPEAT 411..448
FT /note="WD 5"
FT REPEAT 453..492
FT /note="WD 6"
FT REPEAT 498..537
FT /note="WD 7"
FT REPEAT 560..602
FT /note="WD 8"
FT REPEAT 642..683
FT /note="WD 9"
FT REPEAT 765..806
FT /note="WD 10"
FT REPEAT 809..850
FT /note="WD 11"
FT REPEAT 863..902
FT /note="WD 12"
FT REGION 724..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 581..639
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033510"
FT VAR_SEQ 954..962
FT /note="WKKMSSMSL -> FADMLWKVS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033511"
FT VAR_SEQ 963..1086
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033512"
FT CONFLICT 456
FT /note="R -> G (in Ref. 2; BAB29725)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1086 AA; 123893 MW; B8A80ED6F6BFD3E3 CRC64;
MDAKDEKRFN LALQINNFKA SLVEFNKLVE QTTAQKKEER AGIFIPKEDS IDYDKFYTSV
QQIFGPEVKN QDVKCFYRKL CNNPDAAFDW CEIFGYFSTD EDSLTSQMDE ENLVFLVSRK
QRIVIAGSRR RDVIKCIVKV PQLDLLITAS QKGLITVFNS QDTSWITGCD YLGQLKRIVA
TTERTIIVWD YKAQGSSQEH YFVIKPMDHC LLCVCVVPLP DQLCRDDILL GDDGGFVNKF
TVSSDDFGLK QAKTKKKLQT QVLDSKNFKS VKRKLHNDWV MKIRYIPALN CFGSCSLDSV
HSLVLESLKR LEDNLPVREF AMPRGANSFC YCGKANVIVT GGDDKVLRLW HPNISTKPVG
KLVGHMFSIT EIVSNEKEQH VISLSSAKVF RVWDIQTLSV LQVFHDSQGG PGDMQIYSMV
YDANHGMLIT GSGVIDMYPL TRMIQDTKQV PHTHEREVNV TLYNKYFHQV LTVCSESVIK
VWELETGLQI YQILDPHGLS IELTCAAIDE SGYLFATGAY NGTVKIWDFG SGQEMKMMPE
GKDWVEEEHG LMRLFFLKPQ VKQQHLILAL ERNGTIKIIQ GKEDDIFLTV IWELPDAMPY
LQYGSHIVHL KMSTKERTMA IPFPDVELIV QKTSQQTNYS PIVDVDVNCI DVFQTEGYNL
IACGTTNGMI ILWNFIAASV KEIYRPEDCF STDPELDPKR FRINDIMFLF RSPECVRRSS
QDSICSSTQC DSSKGPQSSK GSKQSIHDAD VKGEHTDMVG EQQSASRKQP VPISFVEPQP
PLLVSAHEDG HLRLWTLEGK LIKDMLPFTK HSAISLTSLY TDSCCRVLLA GNVEGHVILC
SISSFMDPPH DEKKFKQLLS WRAHSLEIIQ VIYVEEKQLV LTASIDGSVR IWNSTSGHYC
GYFGQRRMFD LSQTSDFILP CDVNEYPIEI KEESKFTEKT QKYEYPLIFD RERWKKMSSM
SLLFKRPPLS PFEVQHDFKF FKSLSSPKIR RYALEGFLTE NREAGIVFGS LPIYRVPSPT
SLRFLPLIGS EVQRDSVEGV YMKKKHDKVK REEAPEMTEG SRRKSLKRNL VPQINLASSF
FPTTPK
