ID   WDR6_BOVIN              Reviewed;        1124 AA.
AC   A7Z052;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=WD repeat-containing protein 6;
GN   Name=WDR6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enhances the STK11/LKB1-induced cell growth suppression
CC       activity. Negative regulator of amino acid starvation-induced
CC       autophagy. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STK11/LKB1. Interacts with IRS4 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes in the
CC       cytoplasm with STK11/LKB1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC153250; AAI53251.1; -; mRNA.
DR   RefSeq; NP_001099093.1; NM_001105623.1.
DR   AlphaFoldDB; A7Z052; -.
DR   STRING; 9913.ENSBTAP00000025167; -.
DR   PaxDb; A7Z052; -.
DR   PRIDE; A7Z052; -.
DR   GeneID; 526884; -.
DR   KEGG; bta:526884; -.
DR   CTD; 11180; -.
DR   eggNOG; KOG0974; Eukaryota.
DR   HOGENOM; CLU_002615_0_0_1; -.
DR   InParanoid; A7Z052; -.
DR   OrthoDB; 555109at2759; -.
DR   TreeFam; TF313984; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 4.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1124
FT                   /note="WD repeat-containing protein 6"
FT                   /id="PRO_0000393459"
FT   REPEAT          53..97
FT                   /note="WD 1"
FT   REPEAT          105..143
FT                   /note="WD 2"
FT   REPEAT          147..189
FT                   /note="WD 3"
FT   REPEAT          200..238
FT                   /note="WD 4"
FT   REPEAT          247..285
FT                   /note="WD 5"
FT   REPEAT          289..327
FT                   /note="WD 6"
FT   REPEAT          335..376
FT                   /note="WD 7"
FT   REPEAT          381..422
FT                   /note="WD 8"
FT   REPEAT          425..470
FT                   /note="WD 9"
FT   REPEAT          476..520
FT                   /note="WD 10"
FT   REPEAT          557..596
FT                   /note="WD 11"
FT   REPEAT          602..640
FT                   /note="WD 12"
FT   REPEAT          643..682
FT                   /note="WD 13"
FT   REPEAT          743..789
FT                   /note="WD 14"
FT   REPEAT          852..897
FT                   /note="WD 15"
FT   REPEAT          905..950
FT                   /note="WD 16"
FT   REPEAT          974..1015
FT                   /note="WD 17"
FT   REPEAT          1039..1076
FT                   /note="WD 18"
FT   REPEAT          1082..1124
FT                   /note="WD 19"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NNW5"
SQ   SEQUENCE   1124 AA;  122056 MW;  B6E3FBF64D6CFCCF CRC64;
     MDAHEDYVWP RATSELILLP VTGLECVGER LLAGEGPDVL VYTLDFGGHL RMMKRVQNLL
     GHYLIHGFRV RPEPNGDLDS EVMVAAFGSK GLRIVKISWG QGRFRELWRS GLWNMSDWIW
     DARWLEGNIA LALGHNSVVL YDPVVGCSLQ DVPCTDRCTL SSACLIGDTW KELTVVAGAV
     SNQLLVWYPA AALTDDKPVV PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRIWKVGD
     LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
     IRALAAHERQ AWVITGGDDS GIRLWHLVGR GHPGSGVFAL SFKSHSRPGV LKAVTLAGSW
     RVLAVTDAGA LYLYDLEVKC WEQLLEDKRF QSYCLLEAAP GPEGFGLCAL ANGEGRVKVV
     PINTPTAAVD LTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PSGKAIFVKE
     RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVLLYPS RPDLLKDLGV VSKVGAITSA
     PGAGSGEGEP SLAEWGPMST LPSLHGKQGV TSVTCHGGYV YTTGRDGSYY QLFVRGGQLQ
     PVLRQKPCRG MNWVAGVRMV ADGNMVILGF HANEFVVWSP RSHEKLHIIN CGGGHRSWAF
     SDTEAAMAFA YLKDGDVMLY RALGGCTRPH VILRESLHGR EITCVKRVGS ITLGPESGVP
     SFLQPDHLEP GEPVEPGSEG PGLIDIVITC SEDTTVCVLA LPTATGSAHA LTAVCNHISS
     VRAVAVWGVG TPGGPQDPQP GLTAHVVSAG GRAEMHCFTI MVTPDPSPPS RLACHVMHLS
     SHRLDEYWDR QRHRHRMIKV DPETRYMSLA VCELDRPGLG PLVAAACSDG AVRLFLLQDS
     GRRLQLLAET SHHKRCVLKV HAFTHEAPNR RRRLFLCSAA TDGSLAFWDL TTMLDQDSPA
     LEAAADLGLP FQLGSPCLTV QAHSCGVNSL HTLPTREGHL VASGSEDGSL HVFVLAVEMP
     ELEEAVGGAE LLPQLQVLEE YSVPCAHAAH VTGLKILSRS LMVSASIDQR LTFWRLGHGE
     PTFMNSTVYH VADVADMDCW PVSPEFGHRC ALGGQGLEVY NWYD