WDR6_MOUSE
ID WDR6_MOUSE Reviewed; 1125 AA.
AC Q99ME2;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=WD repeat-containing protein 6;
DE Short=mWDR6;
GN Name=Wdr6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Li D., Roberts R.;
RT "Cloning and characterization of mWDR6, a novel mouse WD repeat gene.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, Skin, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Enhances the STK11/LKB1-induced cell growth suppression
CC activity. Negative regulator of amino acid starvation-induced
CC autophagy. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STK11/LKB1. Interacts with IRS4 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes in the
CC cytoplasm with STK11/LKB1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR6 family. {ECO:0000305}.
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DR EMBL; AF348591; AAK31166.1; -; mRNA.
DR EMBL; AK037181; BAC29740.1; -; mRNA.
DR EMBL; AK146617; BAE27306.1; -; mRNA.
DR EMBL; AK163752; BAE37480.1; -; mRNA.
DR EMBL; CH466560; EDL21306.1; -; Genomic_DNA.
DR EMBL; BC050894; AAH50894.1; -; mRNA.
DR EMBL; BC054367; AAH54367.1; -; mRNA.
DR CCDS; CCDS23532.2; -.
DR RefSeq; NP_113569.1; NM_031392.2.
DR AlphaFoldDB; Q99ME2; -.
DR BioGRID; 219954; 36.
DR IntAct; Q99ME2; 1.
DR MINT; Q99ME2; -.
DR STRING; 10090.ENSMUSP00000070927; -.
DR iPTMnet; Q99ME2; -.
DR PhosphoSitePlus; Q99ME2; -.
DR EPD; Q99ME2; -.
DR MaxQB; Q99ME2; -.
DR PaxDb; Q99ME2; -.
DR PRIDE; Q99ME2; -.
DR ProteomicsDB; 297898; -.
DR Antibodypedia; 13436; 102 antibodies from 26 providers.
DR Ensembl; ENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357.
DR GeneID; 83669; -.
DR KEGG; mmu:83669; -.
DR UCSC; uc009rqj.1; mouse.
DR CTD; 11180; -.
DR MGI; MGI:1930140; Wdr6.
DR VEuPathDB; HostDB:ENSMUSG00000066357; -.
DR eggNOG; KOG0974; Eukaryota.
DR GeneTree; ENSGT00420000029923; -.
DR HOGENOM; CLU_002615_0_0_1; -.
DR InParanoid; Q99ME2; -.
DR OMA; HEGSIFY; -.
DR OrthoDB; 555109at2759; -.
DR PhylomeDB; Q99ME2; -.
DR TreeFam; TF313984; -.
DR Reactome; R-MMU-9013420; RHOU GTPase cycle.
DR Reactome; R-MMU-9013424; RHOV GTPase cycle.
DR Reactome; R-MMU-9696264; RND3 GTPase cycle.
DR Reactome; R-MMU-9696270; RND2 GTPase cycle.
DR Reactome; R-MMU-9696273; RND1 GTPase cycle.
DR BioGRID-ORCS; 83669; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Wdr6; mouse.
DR PRO; PR:Q99ME2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q99ME2; protein.
DR Bgee; ENSMUSG00000066357; Expressed in medial preoptic region and 256 other tissues.
DR Genevisible; Q99ME2; MM.
DR GO; GO:0008180; C:COP9 signalosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0043560; F:insulin receptor substrate binding; ISO:MGI.
DR GO; GO:0070314; P:G1 to G0 transition; ISO:MGI.
DR GO; GO:0010507; P:negative regulation of autophagy; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 4.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 3.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell cycle; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1125
FT /note="WD repeat-containing protein 6"
FT /id="PRO_0000393460"
FT REPEAT 53..97
FT /note="WD 1"
FT REPEAT 105..143
FT /note="WD 2"
FT REPEAT 147..189
FT /note="WD 3"
FT REPEAT 200..238
FT /note="WD 4"
FT REPEAT 247..285
FT /note="WD 5"
FT REPEAT 289..327
FT /note="WD 6"
FT REPEAT 335..376
FT /note="WD 7"
FT REPEAT 381..422
FT /note="WD 8"
FT REPEAT 425..470
FT /note="WD 9"
FT REPEAT 476..520
FT /note="WD 10"
FT REPEAT 559..598
FT /note="WD 11"
FT REPEAT 604..642
FT /note="WD 12"
FT REPEAT 645..684
FT /note="WD 13"
FT REPEAT 739..785
FT /note="WD 14"
FT REPEAT 848..897
FT /note="WD 15"
FT REPEAT 905..950
FT /note="WD 16"
FT REPEAT 974..1016
FT /note="WD 17"
FT REPEAT 1040..1077
FT /note="WD 18"
FT REPEAT 1083..1125
FT /note="WD 19"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NNW5"
SQ SEQUENCE 1125 AA; 121898 MW; F228CE5D71554766 CRC64;
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDLGGHL RMVKRVQNLL
GHFLIHGFRV RPEPKGDLDS EAMIAVFGSK GLKVVKVSWG QSHLRELWRS GLWNMSDWIW
DVRWIEGNVA VALGHNSVVL YDPVIGCMLQ DVPCTDRCTL SSACLVGDTW KELTIVAGAV
SNELLIWYPA TALTDNKPVA PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRLWKVGD
LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHRGRG
IRAIATHERQ AWVVTGGDDS GIRLWHLAGR GYPGLGVSSL SFKSPSRPGA LKAVTLAGSW
RVLAVTDVGS LYLYDLEVKS WEQLLEDNRF RSYCLLEAAP GPEGFGLCAL ANGEGLVKVV
PINTPTAAVE QKLFQGKVHS LSWALRGYEE LLLLASGPGG VIACLEISAA PTGKAIFVKE
RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVMLFPV RPCLFKKPGA GSKAITAAEA
PGAGSGSGGS ESVPTGIGPV STLHSLHGKQ GVTSVTCHGG YLYSTGRDSS YFQLFVHGGH
LQPVLRQKAC RGMNWVAGLR MVPDGSMVIL GFHANEFVVW SPRSHEKLHI VNCGGGHRSW
AFSDTEAAMA FTYLKDGEVM LYRALGGCIR PNVILREGLH GREITCVKRV GTVTLGPEFE
VPNLEHPDSL EPGSEGPGLI DIVITGSEDT TVCVLALPTT TGSAHALTSV CNHISSVRAL
AVWAVGTPGG PQDTRPGLTA QVVSAGGRAE IHCFSVMVTP DASTPSRLAC HVMHLSSHRL
DEYWDRQRNK HKMIKVDPET RYMSLAICEL DNDRPGLGPG PLVAAACSDG AVRLFLLQDS
GRILHLLAES FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSLAFWDL TTAMDKGSTT
LELPAHPGLP YQMGTPSMTV QAHSCGVNSL HTLPTPEGHH LVASGSEDGS LHVFTLAVKM
PEPEEADGEA ELVPQLCVLE EYSVPCAHAA HVTGVKILSP KLMVSASIDQ RLTFWRLGQG
EPTFMNSTVY HVPDVADMDC WPVSPEFGHR CALAGQGLEV YNWYD
