ID   WDR6_PONAB              Reviewed;        1121 AA.
AC   Q5RB07;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=WD repeat-containing protein 6;
GN   Name=WDR6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enhances the STK11/LKB1-induced cell growth suppression
CC       activity. Negative regulator of amino acid starvation-induced
CC       autophagy. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STK11/LKB1. Interacts with IRS4 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes in the
CC       cytoplasm with STK11/LKB1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR6 family. {ECO:0000305}.
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DR   EMBL; CR858852; CAH91053.1; -; mRNA.
DR   RefSeq; NP_001127369.1; NM_001133897.1.
DR   AlphaFoldDB; Q5RB07; -.
DR   STRING; 9601.ENSPPYP00000015535; -.
DR   PRIDE; Q5RB07; -.
DR   GeneID; 100174434; -.
DR   KEGG; pon:100174434; -.
DR   CTD; 11180; -.
DR   eggNOG; KOG0974; Eukaryota.
DR   InParanoid; Q5RB07; -.
DR   OrthoDB; 555109at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 4.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1121
FT                   /note="WD repeat-containing protein 6"
FT                   /id="PRO_0000393461"
FT   REPEAT          53..97
FT                   /note="WD 1"
FT   REPEAT          105..143
FT                   /note="WD 2"
FT   REPEAT          147..189
FT                   /note="WD 3"
FT   REPEAT          200..238
FT                   /note="WD 4"
FT   REPEAT          247..285
FT                   /note="WD 5"
FT   REPEAT          289..327
FT                   /note="WD 6"
FT   REPEAT          335..376
FT                   /note="WD 7"
FT   REPEAT          381..422
FT                   /note="WD 8"
FT   REPEAT          425..470
FT                   /note="WD 9"
FT   REPEAT          476..520
FT                   /note="WD 10"
FT   REPEAT          559..598
FT                   /note="WD 11"
FT   REPEAT          604..642
FT                   /note="WD 12"
FT   REPEAT          645..684
FT                   /note="WD 13"
FT   REPEAT          739..785
FT                   /note="WD 14"
FT   REPEAT          848..893
FT                   /note="WD 15"
FT   REPEAT          901..946
FT                   /note="WD 16"
FT   REPEAT          970..1012
FT                   /note="WD 17"
FT   REPEAT          1036..1073
FT                   /note="WD 18"
FT   REPEAT          1079..1121
FT                   /note="WD 19"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NNW5"
SQ   SEQUENCE   1121 AA;  121735 MW;  0CDFAC2EBD404AF6 CRC64;
     MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL RMIKRVQNLL
     GHYLIHGFRI RPEPNGDLDL EAMVAVFGSK GLRVVKISWG QGHFRELWRS GLWNMSDWIW
     DARWLEGNIA LALGHNSVVL YDPVVGCILQ EVPCTDRCTL SSACLIGDAW KELTIVAGAV
     SNQLLVWYPA TALADNKPVA PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD
     LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
     IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT LKAVTLAGSW
     RLLAVTDTGA LYLYDVEVKR WEQLLEDKHF QSYCLLEAAP GPEGFGLCAM ANGEGRVKVV
     PINTPTAAVD RTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PSGKAIFVKE
     RCRYLLPPSK QRWHTCSAFL PPGDFLVCSD RRGSVLLFPS RPGLLKDPGV GGKAGAGAGA
     PGVGSGSSGG GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDSQ
     LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI VNCGGGHRSW
     AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH GREITCVKRV GTITLGPEYG
     VPSFMQPDDL EPGSEGPDLT DIVITCSEDT TVCVLALPTT TGSAHALTAV CNHISSVRAV
     AVWGIGTPGG PQDPQPGLSA HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL
     DEYWDRQHNR HRMVKVDPET RYMSLAVCEL DQPSLGPLVA AACSDGAVRL FLLQDSGRIL
     QLLAETFHHK RCVLKVHSFT HEVPNQRRRL LLCSAATDGS LAFWDLTTML DHDSTVLEPP
     VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS GSEDGSLHVF VLAVEMLELE
     EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG LKILSPSIMV SASIDQRLTF WRLGHGEPTF
     MNSTVFHVPD VADMDCWPVS PEFGHRCALG GQGLEVYNWY D