WDR6_RAT
ID WDR6_RAT Reviewed; 1125 AA.
AC Q5XFW6;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=WD repeat-containing protein 6;
GN Name=Wdr6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH IRS4, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=17720279; DOI=10.1016/j.neurobiolaging.2007.07.008;
RA Chiba T., Inoue D., Mizuno A., Komatsu T., Fujita S., Kubota H.,
RA Luisa Tagliaro M., Park S., Trindade L.S., Hayashida T., Hayashi H.,
RA Yamaza H., Higami Y., Shimokawa I.;
RT "Identification and characterization of an insulin receptor substrate 4-
RT interacting protein in rat brain: implications for longevity.";
RL Neurobiol. Aging 30:474-482(2009).
CC -!- FUNCTION: Enhances the STK11/LKB1-induced cell growth suppression
CC activity. Negative regulator of amino acid starvation-induced
CC autophagy. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STK11/LKB1 (By similarity). Interacts with
CC IRS4. {ECO:0000250, ECO:0000269|PubMed:17720279}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes in the
CC cytoplasm with STK11/LKB1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5XFW6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5XFW6-2; Sequence=VSP_038996;
CC -!- TISSUE SPECIFICITY: Expressed in hypothalamus, hippocampus, cerebrum
CC cortex and cerebellum. {ECO:0000269|PubMed:17720279}.
CC -!- INDUCTION: Down-regulated by caloric restriction. Up-regulated by
CC insulin and IGF1. {ECO:0000269|PubMed:17720279}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR6 family. {ECO:0000305}.
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DR EMBL; CH473954; EDL77156.1; -; Genomic_DNA.
DR EMBL; BC084708; AAH84708.1; -; mRNA.
DR RefSeq; NP_001006989.2; NM_001006988.2. [Q5XFW6-1]
DR AlphaFoldDB; Q5XFW6; -.
DR STRING; 10116.ENSRNOP00000027411; -.
DR jPOST; Q5XFW6; -.
DR PaxDb; Q5XFW6; -.
DR PRIDE; Q5XFW6; -.
DR Ensembl; ENSRNOT00000027411; ENSRNOP00000027411; ENSRNOG00000020185. [Q5XFW6-1]
DR GeneID; 301007; -.
DR KEGG; rno:301007; -.
DR CTD; 11180; -.
DR RGD; 1307649; Wdr6.
DR eggNOG; KOG0974; Eukaryota.
DR GeneTree; ENSGT00420000029923; -.
DR HOGENOM; CLU_002615_0_0_1; -.
DR InParanoid; Q5XFW6; -.
DR OMA; HEGSIFY; -.
DR OrthoDB; 555109at2759; -.
DR PhylomeDB; Q5XFW6; -.
DR TreeFam; TF313984; -.
DR Reactome; R-RNO-9013420; RHOU GTPase cycle.
DR Reactome; R-RNO-9013424; RHOV GTPase cycle.
DR Reactome; R-RNO-9696264; RND3 GTPase cycle.
DR Reactome; R-RNO-9696270; RND2 GTPase cycle.
DR Reactome; R-RNO-9696273; RND1 GTPase cycle.
DR PRO; PR:Q5XFW6; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Proteomes; UP000234681; Chromosome 8.
DR Bgee; ENSRNOG00000020185; Expressed in frontal cortex and 19 other tissues.
DR Genevisible; Q5XFW6; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0032991; C:protein-containing complex; IDA:RGD.
DR GO; GO:0043560; F:insulin receptor substrate binding; IPI:RGD.
DR GO; GO:0070314; P:G1 to G0 transition; ISO:RGD.
DR GO; GO:0008286; P:insulin receptor signaling pathway; NAS:RGD.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; NAS:RGD.
DR GO; GO:0010507; P:negative regulation of autophagy; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50978; SSF50978; 2.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell cycle; Cytoplasm;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1125
FT /note="WD repeat-containing protein 6"
FT /id="PRO_0000393462"
FT REPEAT 89..130
FT /note="WD 1"
FT REPEAT 155..197
FT /note="WD 2"
FT REPEAT 207..246
FT /note="WD 3"
FT REPEAT 256..294
FT /note="WD 4"
FT REPEAT 295..335
FT /note="WD 5"
FT REPEAT 346..384
FT /note="WD 6"
FT REPEAT 433..475
FT /note="WD 7"
FT REPEAT 489..528
FT /note="WD 8"
FT REPEAT 567..605
FT /note="WD 9"
FT REPEAT 611..650
FT /note="WD 10"
FT REPEAT 652..692
FT /note="WD 11"
FT REPEAT 725..765
FT /note="WD 12"
FT REPEAT 767..798
FT /note="WD 13"
FT REPEAT 860..905
FT /note="WD 14"
FT REPEAT 912..958
FT /note="WD 15"
FT REPEAT 982..1024
FT /note="WD 16"
FT REPEAT 1047..1085
FT /note="WD 17"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NNW5"
FT VAR_SEQ 1..972
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038996"
SQ SEQUENCE 1125 AA; 121937 MW; BEDB0EC753FFAF1A CRC64;
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDFGGHL RMVKRVQNLL
GHYLIHGFRV QPEPKGDLDS EAMIAVFGSK GLRVVKISWG QSHLRELWRS GLWNMSDWIW
DARWLEGNVA LALGHNSVVL YDPVIGCMLQ DVPCTDRCTL SSACLIGDTW KELTIVAGAV
SNELLVWYPA TALPDNKPVA PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRIWKVGD
LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
IRAIAAHERQ TWVITGGDDS GIRLWHLVGR GYPGLGVSSL SFKSPSRPGA LKAVTLAGSW
RVLAVTDVGG LYLYDLEVKC WEQLLEDNRF QSYCLLEAAP GPEGFGLCAL ANGEGLVKVV
PINTPTAAVD QNLFQGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PTGKAIFVKE
RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVLLFPA RPCLFKKPGV GPKAITAAEA
PQAGSSSGGS ESVVTGLGPV SSLHSLHGKQ GVTSVTCHGG YVYSTGRDGS YYQLFVHGGR
LQPVLRQKAC RGMNWIAGLR MAPDGSMVVL GFHANEFVVW SPRSHEKLHI VNCGGGHRSW
AFSDTEAAMA FAYLKDGDVM LYRALGGCIR PNVILREGLH GREITCVKRV GTVTLGPEFE
VPNLEHPDSL EPGSEGPGLI DIVITGSEDT TVCVLALPTT TGAAHALTAV CNHISSVRAL
AVWGVGTPGG PQDSHPGLTA QVVSAGGRAE MHCFSLMITP DASTPSRLAC HIMHLSSHRL
DEYWDRQRNR HRMIKVDPET RYMSLAICEL DSDRPGLGPG PLVAAACSDG AVRLFLLQDS
GRILHLLAET FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSIAFWDL TTAMDRGSTT
LEPPAHPGLP YQMGTPCLTV QAHSCGVNSL HTLPTPEGHH LVASGSEDGS LHVFTLAVKM
PELEEADGEA ELVPQLCVLD EYSVPCAHAA HVTGIKILSP KLMVSASIDQ RLTFWRLGNG
EPTFMNSTVY HVPDVADMDC WPVNPEFGHR CALAGQGLEV YNWYD
