WDR6_SCHPO
ID WDR6_SCHPO Reviewed; 984 AA.
AC Q9USZ0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Uncharacterized WD repeat-containing protein C1306.02;
GN ORFNames=SPBC1306.02, SPBC4.08;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: May play a role in the regulation of the retromer complex and
CC in the recycling from endosomes of plasma membrane proteins. May be
CC involved in the methylation of the 2'-O-ribose of nucleotides at
CC position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA))
CC by SPAC4F10.03c (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR6 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB62092.1; -; Genomic_DNA.
DR PIR; T50309; T50309.
DR RefSeq; NP_595473.1; NM_001021384.2.
DR AlphaFoldDB; Q9USZ0; -.
DR BioGRID; 276462; 3.
DR STRING; 4896.SPBC1306.02.1; -.
DR MaxQB; Q9USZ0; -.
DR PaxDb; Q9USZ0; -.
DR EnsemblFungi; SPBC1306.02.1; SPBC1306.02.1:pep; SPBC1306.02.
DR GeneID; 2539918; -.
DR KEGG; spo:SPBC1306.02; -.
DR PomBase; SPBC1306.02; -.
DR VEuPathDB; FungiDB:SPBC1306.02; -.
DR eggNOG; KOG0974; Eukaryota.
DR HOGENOM; CLU_002615_0_1_1; -.
DR InParanoid; Q9USZ0; -.
DR OMA; CNSEGST; -.
DR PhylomeDB; Q9USZ0; -.
DR Reactome; R-SPO-9013420; RHOU GTPase cycle.
DR Reactome; R-SPO-9013424; RHOV GTPase cycle.
DR Reactome; R-SPO-9696273; RND1 GTPase cycle.
DR PRO; PR:Q9USZ0; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030488; P:tRNA methylation; IMP:PomBase.
DR Gene3D; 2.130.10.10; -; 5.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT CHAIN 1..984
FT /note="Uncharacterized WD repeat-containing protein
FT C1306.02"
FT /id="PRO_0000316567"
FT REPEAT 14..52
FT /note="WD 1"
FT REPEAT 142..183
FT /note="WD 2"
FT REPEAT 192..231
FT /note="WD 3"
FT REPEAT 235..275
FT /note="WD 4"
FT REPEAT 278..318
FT /note="WD 5"
FT REPEAT 326..364
FT /note="WD 6"
FT REPEAT 366..407
FT /note="WD 7"
FT REPEAT 461..502
FT /note="WD 8"
FT REPEAT 507..549
FT /note="WD 9"
FT REPEAT 650..689
FT /note="WD 10"
FT REPEAT 695..733
FT /note="WD 11"
FT REPEAT 752..797
FT /note="WD 12"
FT REPEAT 806..845
FT /note="WD 13"
FT REPEAT 854..899
FT /note="WD 14"
FT REPEAT 910..949
FT /note="WD 15"
SQ SEQUENCE 984 AA; 110977 MW; FA9854A13B1E82A6 CRC64;
MLVEGDKGVL EPVNFVGPVT SLALIHNDKF LCCAQGPCLR IYDVSESRHE SDLIKSILLP
FHNRIHGMLP CKQGLFVWGG TYFAVVDVET SQVYYDRISD WIFNAAELGE ENKFCVVTSK
NQVHLLSLSK GSWEVTNTIS CEKTPLLFCA TVQISGNEIY IASASAFQQI YVWKFNYNNP
PSCVSIDTYL VGHEGACFDL KFSSDGRYLC SVSEDRTLRL WSIESSPFLI ATGFGHSARV
WRCVFLPNKE IATVSEDLTL RLWTWNDKTL TNTYTYTGHR GKHIWSLVVS SANPIIYTGG
NDGSVRSWDY KTRIQESCIS VSSLFTSKTL LASFCFVKCQ KLLCLAKNGE MSIIDNKGKK
AIPALTTTSD MSIIRSWKNS FFVAAASNKG TIYVFSYQNT NLLKAIDLHR GKIQQLLTYQ
VKERYFLLSK SFVGKNQFRV YLQEFDFEAD KVNLISTIEL ELPATFDPTS LTVDEEYSNF
LIGSRTGSLA LYNIGESNYL SVWRRIHEFD AISSIHIKSS KRDYLLIQTV GRDGYVNLFS
IPRVEKSAVP QELCSKKCCD GILSGGLCKK LKNGKENQWV WGFHASNFFL RDETNETNVF
FIDCGGSHRP WAFSMEMDIQ SFASYRANQL YIYSTALNLL QRNSVLQNGL HGREIRAMDF
NPSGDLLLSG SEDTKVTLLE FQSNGNIIPL NSVKFHNSGI QSLTWFSDDI LFSTGGLEEL
NVYRLIQKPE AYLKRIVHEK LCKPNKSNKT YDGDLRITDI SVVKATHLGE RVLWINTVQS
DSTIKAFTYN VDTKQLNCIK SWKYKTVCLV FAEAVIFGSH LLLVVASTDG NVAIWNTFWR
DPQIEPLIIW IKTVHQFCVK SLNISRDQDV LTISTGGDDG AISRSILLLE QISENSVVVN
SLHNYFFAEA HASSVTGVLS ITKELLLSVS IDQRILLWKV EGDSLKPILE RYTHVADVGG
MIRNNDFLII YGIGCEVFRL GSLR
