ID   WDR70_BOVIN             Reviewed;         652 AA.
AC   Q32LB0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=WD repeat-containing protein 70;
GN   Name=WDR70;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WD repeat GAD-1 family. {ECO:0000305}.
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DR   EMBL; BC109667; AAI09668.1; -; mRNA.
DR   RefSeq; NP_001069706.1; NM_001076238.2.
DR   AlphaFoldDB; Q32LB0; -.
DR   SMR; Q32LB0; -.
DR   STRING; 9913.ENSBTAP00000044228; -.
DR   PaxDb; Q32LB0; -.
DR   PRIDE; Q32LB0; -.
DR   GeneID; 540724; -.
DR   KEGG; bta:540724; -.
DR   CTD; 55100; -.
DR   eggNOG; KOG0772; Eukaryota.
DR   InParanoid; Q32LB0; -.
DR   OrthoDB; 729650at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation; WD repeat.
FT   CHAIN           1..652
FT                   /note="WD repeat-containing protein 70"
FT                   /id="PRO_0000305143"
FT   REPEAT          178..217
FT                   /note="WD 1"
FT   REPEAT          225..266
FT                   /note="WD 2"
FT   REPEAT          279..319
FT                   /note="WD 3"
FT   REPEAT          328..367
FT                   /note="WD 4"
FT   REPEAT          374..413
FT                   /note="WD 5"
FT   REPEAT          419..464
FT                   /note="WD 6"
FT   REPEAT          467..506
FT                   /note="WD 7"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..160
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..560
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..652
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         450
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT   MOD_RES         577
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT   MOD_RES         619
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT   MOD_RES         636
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT   CROSSLNK        294
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT   CROSSLNK        588
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
FT   CROSSLNK        594
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NW82"
SQ   SEQUENCE   652 AA;  72641 MW;  CBA88E3246EBF80A CRC64;
     MERPGPSDGS DASGPDPQLA VTMGFTGFGK KARTFDLEAM FEQTRRTAVE RSRKTLEARE
     REEEMNREKE LRRQNEDLEP TSSGSNVARA CSKSSSRDTS SSESDESSDS SDDELIGPPL
     PLKMVEEPVN PMEEGVLGPL PPPLAEDVEE EDDDDGDSEE EENPVRKIPD SHEITIKHGT
     KTVSALGLDP SGARLVTGGY DYDVKFWDFA GMDASFKAFR SLQPCECHQI KSLQYSNTGD
     MILVVSGSSQ AKVIDRDGFE VMECIKGDQY IVDMANTKGH TAMLHTGSWH PKIKGEFMTC
     SNDATVRTWE VENPKKQKSV FKPRTMQGKK VIPTTCTYSR DGSLIAAACQ NGSIQIWDRN
     LTVHPKFHYK QAHDPGTDTS CVTFSYDGTV LASRGGDDTL KLWDIRQFNK PLFSASGLPT
     MFPMTDCCFS PDDKLIVTGT SVQRGCGSGK LVFFERRTFQ RVYEIDITDA SVVRCLWHPK
     LNQIMVGTGN GLAKVYYDPN KSQRGAKLCV VKTQRKAKQA ETLTQDYIIT PHALPMFREP
     RQRSTRKQLE KDRLDPLKSH KPEPPVAGPG RGGRVGTHGG TLSSYIVKNI ALDKTDDSNP
     REAILRHAKA AEDNPYWVSP AYSKTQPKTM FAQVESDDEE TKNEPEWKKR KI