ID   WDR70_XENLA             Reviewed;         622 AA.
AC   Q6GPP0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=WD repeat-containing protein 70;
GN   Name=wdr70;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WD repeat GAD-1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH73073.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC073073; AAH73073.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001085643.2; NM_001092174.1.
DR   AlphaFoldDB; Q6GPP0; -.
DR   SMR; Q6GPP0; -.
DR   GeneID; 444069; -.
DR   KEGG; xla:444069; -.
DR   CTD; 444069; -.
DR   Xenbase; XB-GENE-956092; wdr70.L.
DR   OrthoDB; 729650at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 444069; Expressed in liver and 19 other tissues.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..622
FT                   /note="WD repeat-containing protein 70"
FT                   /id="PRO_0000305147"
FT   REPEAT          148..187
FT                   /note="WD 1"
FT   REPEAT          195..236
FT                   /note="WD 2"
FT   REPEAT          249..289
FT                   /note="WD 3"
FT   REPEAT          298..337
FT                   /note="WD 4"
FT   REPEAT          344..383
FT                   /note="WD 5"
FT   REPEAT          387..434
FT                   /note="WD 6"
FT   REPEAT          437..476
FT                   /note="WD 7"
FT   REGION          36..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..133
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..530
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  68816 MW;  F6D19E9E0A64AC61 CRC64;
     MDENEDSSIA ATMGFSGFGK KARTFDLEAM FEQTRRTAVE RSKQTLEARE KEEQLSNKSP
     VIKGAPSSSG QKKTKASGSS SGSEDSSDDE LIGPPLPPNV TGDHGDELIG PPLPPGYKDS
     DDEDDEEHED DDNPVKDIPD SHEITLQHGT KTVSALGLDP SGARLVTGGY DYDVRFWDFA
     GMDASLQAFR SLQPCECHQI KSLQYSNTGD VILVVAGNSQ AKVLDRDGFP VMECVKGDQY
     IVDMANTKGH TAMLNGGCWH PKIKEEFMTC SNDGTVRTWD VSNEKKHKGI FKPRSVQGKP
     VIPTCCTYSR DGKFIAAGCQ DGSIQIWDRN MSVHTKFHCR QAHTPGTDTS CVTFSYGGNV
     LATRGGDDTL KTWDIRKFKN PLNVASGLEN FFPMTDCCFS PDDKLLITGT SVKRGIGDGK
     LLFFDVVTFQ KIYEIQVTEA SVVRCLWHPK LNQIMVGTGN GLAKVYYDPN RSQRGAKLCV
     VKTQRKERQA ETLTQDYIIT PHALPMFREP RQRSTRKQLE KDRLDPVKSH KPEPPVAGPG
     RGGRVGTHGG TLSSFIVKNI ALDKTDDSNA REAILRHAKD AEQNPYWVAP AYSKTQPNTV
     FAEVDSDEEE PDNEPEWKKR KI