ID   WDR70_XENTR             Reviewed;         622 AA.
AC   Q0VA16;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=WD repeat-containing protein 70;
GN   Name=wdr70;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WD repeat GAD-1 family. {ECO:0000305}.
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DR   EMBL; BC121303; AAI21304.1; -; mRNA.
DR   RefSeq; NP_001072792.1; NM_001079324.2.
DR   RefSeq; XP_012821388.1; XM_012965934.2.
DR   RefSeq; XP_012821394.1; XM_012965940.2.
DR   AlphaFoldDB; Q0VA16; -.
DR   SMR; Q0VA16; -.
DR   PaxDb; Q0VA16; -.
DR   DNASU; 780253; -.
DR   GeneID; 780253; -.
DR   KEGG; xtr:780253; -.
DR   CTD; 55100; -.
DR   Xenbase; XB-GENE-956087; wdr70.
DR   eggNOG; KOG0772; Eukaryota.
DR   InParanoid; Q0VA16; -.
DR   OrthoDB; 729650at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004784; Expressed in gastrula and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR   GO; GO:1903775; P:regulation of DNA double-strand break processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..622
FT                   /note="WD repeat-containing protein 70"
FT                   /id="PRO_0000305148"
FT   REPEAT          148..187
FT                   /note="WD 1"
FT   REPEAT          195..236
FT                   /note="WD 2"
FT   REPEAT          249..289
FT                   /note="WD 3"
FT   REPEAT          298..337
FT                   /note="WD 4"
FT   REPEAT          344..383
FT                   /note="WD 5"
FT   REPEAT          389..434
FT                   /note="WD 6"
FT   REPEAT          437..476
FT                   /note="WD 7"
FT   REGION          37..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..530
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  68926 MW;  A908153C6C7B0AC8 CRC64;
     MDENEDSSIA ATMGFSGFGK KARTFDLEAM FEQTRRTAVE RSKKTLEARE KEEQISNKSP
     VMKDVPSSSR QKNTDTSSSS SGSEDSSDDE LIGPPVPSNL TGDHGDELIG PPLPSGYKDS
     DDEDEEQHED DDNPVKGIPD SHEITLQHGT KTVSALGLDP SGARLVTGGF DYDVRFWDFA
     GMDASLQAFR SLQPCECHQI KSLQYSNTGD VILVVAGNSQ AKVLDRDGFP VMECVKGDQY
     IVDMANTKGH TAMLNGGCWH PKIKEEFMTC SNDGTVRTWD VSNEKKHKGV FKPRSMQGKR
     VIPTCCTYSR DGKFIAAGCQ DGSIQIWDRN MSVHTKFHCR QAHTPGTDTS CVTFSYAGNI
     LATRGGDDTL KTWDIRKFKN PLNVASGLAN YFPMTDCCFS PDDKLLITGT SVKRGGGDGK
     LMFFDVGTFQ KVYEIQVTEA SVVRCLWHPK LNQIMVGTGN GLAKVYYDPN RSQRGAKLCV
     VKTQRKARQA ETLTQDYIIT PHALPMFREP RQRSTRKQLE KDRLDPVKSH KPEPPVAGPG
     RGGRVGTHGG TLSSFIVKNI ALDKTDDSNP REAILRHAKD AEKNPYWVAP AYSKTQPNTV
     FAEVESDEEE TDNEPEWKKR KI