ID   WDR72_PONAB             Reviewed;        1098 AA.
AC   Q5RFQ4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=WD repeat-containing protein 72;
GN   Name=WDR72;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in formation of tooth enamel. Specifically
CC       required during the maturation phase of amelogenesis for normal
CC       formation of the enamel matrix and clearance of enamel proteins. May be
CC       involved in localization of the calcium transporter SLC24A4 to the
CC       ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:D3YYM4}.
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DR   EMBL; CR857098; CAH89403.1; -; mRNA.
DR   RefSeq; NP_001124592.1; NM_001131120.1.
DR   AlphaFoldDB; Q5RFQ4; -.
DR   STRING; 9601.ENSPPYP00000007359; -.
DR   GeneID; 100450039; -.
DR   KEGG; pon:100450039; -.
DR   CTD; 256764; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   InParanoid; Q5RFQ4; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Biomineralization; Cytoplasmic vesicle; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..1098
FT                   /note="WD repeat-containing protein 72"
FT                   /id="PRO_0000241448"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          60..102
FT                   /note="WD 2"
FT   REPEAT          158..196
FT                   /note="WD 3"
FT   REPEAT          315..359
FT                   /note="WD 4"
FT   REPEAT          399..438
FT                   /note="WD 5"
FT   REPEAT          456..501
FT                   /note="WD 6"
FT   REPEAT          504..549
FT                   /note="WD 7"
FT   REPEAT          552..591
FT                   /note="WD 8"
FT   MOD_RES         1077
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:D3YYM4"
FT   MOD_RES         1079
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:D3YYM4"
SQ   SEQUENCE   1098 AA;  123046 MW;  6E2697F93236DC1E CRC64;
     MRTSLQAVAL WGQKAPPHSI TAIMITDDQR MIVTGSQEGQ LCLWNLSHEL KISAKELLFG
     HSASVTCLAR ARDFSKQPYI VSAAENGEMC VWNVTNGQCV EKATLPYRHT AICYYHCSFR
     MTGEGWLLCC GEYQDVLIID AKTLAVVHSF RSSQFPDWIN CMCIVHSMRI QDSLLVVSVA
     GELKVWDLSS SINSIQEKQD VYEKESKFLE SLNCQTIRFC TYTERLLLVV FSKCWKVYDY
     CDFSLLLTEV SRNGQFFAGG EVIAAHRILI WTEDGHSYIY QLLNSGLSKS IYPADGRVLK
     ETIYPHLLCS TSVQENKNRP FVMGYMNERK EPFYKVLFSG EVSGRITLWH IPDVPVSKFD
     GSPREIPVTA TWTLQDNFDK HDTVSQSIID YFSGLKDGAG TAVVTSSEYI PSLDKLICGC
     EDGTIIITQA LNAAKARLLE GGSLVKDSSP HKVLKGHHQS VTSLLYPHGL SSKLDQSWML
     SGDLDSCVIL WDIFTEEILH KFFLEAGPVT SLLMSPEKFK LRGAQIICCV CSDHSVALLH
     LEGRSCLLRA RKHLFPVKMI KWHPVENFLI VGCADDSVYI WEIETGTLER HETGERARII
     LNCCDDSQLV KSVFPIASET LKHKSIEQRS SSPYQLGPLP CPGLQVESSC KVIDAKFCPR
     PFNVLPVKTK WSNVGFHILL FDLENLVELL LPTPLSDVDS SSSFYGGEVL RRAKSTVEKK
     TLTLRKSKTA CGPLSAEALA KPITESPAQG DNTIKFSAEN DGIKRQKKMK ISKKMQPKPS
     RKVDASLTID TAKLFLSCLL PWGVDDLDYL CIKHLNILKL QGPISLGFAS NEDNFSLMLP
     GWDLCNTEMI KDYSGVNLFS RKVLDLSDKY TATLPNQVGI PRGLENNCDS LQESDTIVYL
     LSRLFLVNKL VNMPLELACR VGSSFRMECV HNKVRSAGND ILNMSSFYSC LRNGKNESHV
     PEADLSLLKL ISCWRDQSVQ VTEAIQAVLW AEVQQHMKSL GKIPVNSQPV SMAENGNCEM
     KQMLPKLEWT EELELQCIRN TLPLQTPVSP VKHDSNLNSA NIQDMEDMPD RCVLEESESP
     GEPRHHSWIA KVCPCKVS