WDR73_DANRE
ID WDR73_DANRE Reviewed; 376 AA.
AC Q567G2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=WD repeat-containing protein 73;
GN Name=wdr73; ORFNames=zgc:112071;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in the regulation of microtubule organization
CC and dynamics. {ECO:0000250|UniProtKB:Q6P4I2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250|UniProtKB:Q6P4I2}. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000250|UniProtKB:Q6P4I2}. Cleavage furrow
CC {ECO:0000250|UniProtKB:Q6P4I2}. Note=During interphase, located in the
CC cytosol. During mitosis, accumulates at the spindle poles and
CC microtubule asters and later in the cleavage furrow.
CC {ECO:0000250|UniProtKB:Q6P4I2}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR73 family. {ECO:0000305}.
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DR EMBL; BC093184; AAH93184.1; -; mRNA.
DR RefSeq; NP_001017646.1; NM_001017646.1.
DR AlphaFoldDB; Q567G2; -.
DR SMR; Q567G2; -.
DR STRING; 7955.ENSDARP00000032408; -.
DR PaxDb; Q567G2; -.
DR GeneID; 550339; -.
DR KEGG; dre:550339; -.
DR CTD; 84942; -.
DR ZFIN; ZDB-GENE-050417-126; wdr73.
DR eggNOG; KOG0264; Eukaryota.
DR InParanoid; Q567G2; -.
DR OrthoDB; 791631at2759; -.
DR PhylomeDB; Q567G2; -.
DR PRO; PR:Q567G2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:ZFIN.
DR GO; GO:0021549; P:cerebellum development; IMP:ZFIN.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0030901; P:midbrain development; IMP:ZFIN.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR042795; Wdr73.
DR PANTHER; PTHR46947; PTHR46947; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..376
FT /note="WD repeat-containing protein 73"
FT /id="PRO_0000307282"
FT REPEAT 84..123
FT /note="WD 1"
FT REPEAT 276..316
FT /note="WD 2"
FT REPEAT 337..376
FT /note="WD 3"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41235 MW; F3B213CBF7B695F0 CRC64;
MDISSDESDD WFMESLNAYR DLHLFQLEHP TKVIEWMGDK SICVAGYTGA RSEILELLLP
LKLYAGDNQG LCAERDFKVK HGGFSEEPVE CLIHIPGTRC LVTSGNSNTL QIWDIGGDDS
DVIKMTRVIN LKSPSAKGSK ITPGFTDSPT VLHGSCISDI QLTEIATGRV LHTVGKESSD
SVSGLQFVNA FVFLICSTNG ALLLGDTRDP STCHYPLEES NSGLRWSFGL RSDSSQSEPS
CCKVARLSSS GHMLLSDLRD LKSPFCQTQI KVPQSASKNH FMNISWAPVL DKCLSVSGFD
GTVHIYNTNN WSTESSSPQP IFSHRGHEMS QEAKSSTSPA VVTAHSWHPS RPKTLLSAAT
DGSLHVWDWV DKITDR
