WDR73_MOUSE
ID WDR73_MOUSE Reviewed; 371 AA.
AC Q9CWR1; Q05C70; Q3TEN7; Q571I2; Q8BSB9; Q8CF62;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=WD repeat-containing protein 73;
GN Name=Wdr73;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Lung, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Spleen;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Kitamura H., Nagase T.,
RA Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in the regulation of microtubule organization
CC and dynamics. {ECO:0000250|UniProtKB:Q6P4I2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250|UniProtKB:Q6P4I2}. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000250|UniProtKB:Q6P4I2}. Cleavage furrow
CC {ECO:0000250|UniProtKB:Q6P4I2}. Note=During interphase, located in the
CC cytosol. During mitosis, accumulates at the spindle poles and
CC microtubule asters and later in the cleavage furrow.
CC {ECO:0000250|UniProtKB:Q6P4I2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9CWR1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CWR1-2; Sequence=VSP_028668;
CC Name=3;
CC IsoId=Q9CWR1-3; Sequence=VSP_028669, VSP_028670;
CC Name=4;
CC IsoId=Q9CWR1-4; Sequence=VSP_028667, VSP_028669;
CC -!- SIMILARITY: Belongs to the WD repeat WDR73 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28870.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD90132.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK004708; BAC25093.1; -; mRNA.
DR EMBL; AK010448; BAB26948.1; -; mRNA.
DR EMBL; AK034740; BAC28814.1; -; mRNA.
DR EMBL; AK049132; BAC33560.1; -; mRNA.
DR EMBL; AK169527; BAE41211.1; -; mRNA.
DR EMBL; AK220207; BAD90132.1; ALT_INIT; mRNA.
DR EMBL; BC028870; AAH28870.1; ALT_FRAME; mRNA.
DR EMBL; BC087940; AAH87940.1; -; mRNA.
DR CCDS; CCDS52282.1; -. [Q9CWR1-1]
DR RefSeq; NP_082302.2; NM_028026.2. [Q9CWR1-1]
DR RefSeq; XP_006541269.1; XM_006541206.1.
DR RefSeq; XP_006541270.1; XM_006541207.3.
DR RefSeq; XP_006541271.1; XM_006541208.2.
DR RefSeq; XP_006541272.1; XM_006541209.1.
DR RefSeq; XP_011249206.1; XM_011250904.1.
DR AlphaFoldDB; Q9CWR1; -.
DR SMR; Q9CWR1; -.
DR STRING; 10090.ENSMUSP00000026816; -.
DR PhosphoSitePlus; Q9CWR1; -.
DR EPD; Q9CWR1; -.
DR MaxQB; Q9CWR1; -.
DR PaxDb; Q9CWR1; -.
DR PeptideAtlas; Q9CWR1; -.
DR PRIDE; Q9CWR1; -.
DR ProteomicsDB; 275207; -. [Q9CWR1-1]
DR ProteomicsDB; 275208; -. [Q9CWR1-2]
DR ProteomicsDB; 275209; -. [Q9CWR1-3]
DR ProteomicsDB; 275210; -. [Q9CWR1-4]
DR Antibodypedia; 50322; 90 antibodies from 19 providers.
DR Ensembl; ENSMUST00000026816; ENSMUSP00000026816; ENSMUSG00000025722. [Q9CWR1-1]
DR GeneID; 71968; -.
DR KEGG; mmu:71968; -.
DR UCSC; uc009ibj.2; mouse. [Q9CWR1-3]
DR UCSC; uc009ibk.2; mouse. [Q9CWR1-1]
DR UCSC; uc033jae.1; mouse. [Q9CWR1-4]
DR CTD; 84942; -.
DR MGI; MGI:1919218; Wdr73.
DR VEuPathDB; HostDB:ENSMUSG00000025722; -.
DR eggNOG; KOG0264; Eukaryota.
DR GeneTree; ENSGT00390000015701; -.
DR HOGENOM; CLU_070481_0_0_1; -.
DR InParanoid; Q9CWR1; -.
DR OMA; HTWHPCK; -.
DR OrthoDB; 791631at2759; -.
DR PhylomeDB; Q9CWR1; -.
DR TreeFam; TF331370; -.
DR BioGRID-ORCS; 71968; 26 hits in 67 CRISPR screens.
DR PRO; PR:Q9CWR1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9CWR1; protein.
DR Bgee; ENSMUSG00000025722; Expressed in cleaving embryo and 223 other tissues.
DR ExpressionAtlas; Q9CWR1; baseline and differential.
DR Genevisible; Q9CWR1; MM.
DR GO; GO:0032154; C:cleavage furrow; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0000922; C:spindle pole; ISO:MGI.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0006997; P:nucleus organization; ISO:MGI.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR042795; Wdr73.
DR PANTHER; PTHR46947; PTHR46947; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..371
FT /note="WD repeat-containing protein 73"
FT /id="PRO_0000307281"
FT REPEAT 81..121
FT /note="WD 1"
FT REPEAT 273..313
FT /note="WD 2"
FT REPEAT 333..371
FT /note="WD 3"
FT VAR_SEQ 1..109
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028667"
FT VAR_SEQ 117
FT /note="N -> NAEPGKKHLSQGTAQFLSTTCNQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028668"
FT VAR_SEQ 296..312
FT /note="FDGTVQIYDVTSWDGKK -> TVENVSLHCSLPEAVGA (in isoform 3
FT and isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028669"
FT VAR_SEQ 313..371
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028670"
FT CONFLICT 91
FT /note="H -> R (in Ref. 1; BAE41211)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="C -> S (in Ref. 2; BAD90132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 40856 MW; 89059680200DA8B7 CRC64;
MELAEDWLVE SLRLYQDFHA FDLSGATRVL EWIGEKGVFV AGYESLKKNE ILHLILPLRL
SVQENQGLHP ERDFKVRHGG FSDRSVFDLK HVPDTRLLVT SGLPGCYIQM WQVREDNDVI
EAVSTIDVQD KEESLWPRVS VFCSKAPGIL HGARLSGLRT VDVESQKITY SSGTADSESL
SCLQVLDANT FAFCGNSGRL GLVDTRQKWA ALETVSPGSG CSGERWCAEV RNKGQGPGPC
IASLGSDGQL CLLDSRNLCH PVSSAQCPVF KPSPDPELLR VTWAPGLDNC LAISGFDGTV
QIYDVTSWDG KKTQAEPLFT HKGHIFLDGN DVDSAPLVTT HTWHPRKPRT LLSAASDSSL
HVWDWVDLQA S
