ID   WDR73_XENLA             Reviewed;         369 AA.
AC   A5D8Q8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=WD repeat-containing protein 73;
GN   Name=wdr73;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adipose tissue;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of microtubule organization
CC       and dynamics. {ECO:0000250|UniProtKB:Q6P4I2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250|UniProtKB:Q6P4I2}. Cytoplasm, cytoskeleton,
CC       spindle pole {ECO:0000250|UniProtKB:Q6P4I2}. Cleavage furrow
CC       {ECO:0000250|UniProtKB:Q6P4I2}. Note=During interphase, located in the
CC       cytosol. During mitosis, accumulates at the spindle poles and
CC       microtubule asters and later in the cleavage furrow.
CC       {ECO:0000250|UniProtKB:Q6P4I2}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR73 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI41774.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC141773; AAI41774.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; A5D8Q8; -.
DR   SMR; A5D8Q8; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR042795; Wdr73.
DR   PANTHER; PTHR46947; PTHR46947; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..369
FT                   /note="WD repeat-containing protein 73"
FT                   /id="PRO_0000307283"
FT   REPEAT          74..114
FT                   /note="WD 1"
FT   REPEAT          266..306
FT                   /note="WD 2"
FT   REPEAT          326..366
FT                   /note="WD 3"
SQ   SEQUENCE   369 AA;  40249 MW;  796C6DDAFECAA62D CRC64;
     MLESIRLYKD LHDFELQGPT RVVEWIGDKS ICVAGYDSAK RNEILQLLIP QKLHAKENPG
     LCPERDLKVE HGGFIDEPVY SLKHIPQSSL IVTSGPASCP LWVWQIGPED RDVIQPISTL
     PSDAGKGTWT RIATTTSASP QILHGSQADS IRLTDIESTK QIHTLGVSGS DGVSTLCFLD
     SRTVFVCCMN GRQFIADIRM PGAASEGRVG EEGLSCVTWC SAVHPSKEDV CSTVASVSSE
     GHMCLTDPRN LSVPLKCATW CTPIPAASEQ FLSICWAPAL SDCISVSGFG GSVQIFDTKR
     WDSAMKEREA VFIHKGHSVM GTCEDGREPT VTAHAWHPWK ERTVLSAASD GSLHVWNWSD
     LPVHDGTEL