WDR75_DANRE
ID WDR75_DANRE Reviewed; 832 AA.
AC Q7ZVR1; Q7ZZ52; Q8AUI8; Q8AW19; Q8JFV9;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=WD repeat-containing protein 75;
GN Name=wdr75; ORFNames=si:dz46i22.2, si:xx-113d7.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q8IWA0}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q8IWA0}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD52129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD52133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD58775.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD61075.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL591593; CAD43475.1; -; Genomic_DNA.
DR EMBL; AL672118; CAD52129.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL672166; CAD52133.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL672145; CAD58775.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL731861; CAD61075.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC045446; AAH45446.1; -; mRNA.
DR RefSeq; NP_956384.1; NM_200090.1.
DR AlphaFoldDB; Q7ZVR1; -.
DR SMR; Q7ZVR1; -.
DR STRING; 7955.ENSDARP00000059666; -.
DR PaxDb; Q7ZVR1; -.
DR Ensembl; ENSDART00000059667; ENSDARP00000059666; ENSDARG00000040730.
DR GeneID; 368478; -.
DR KEGG; dre:368478; -.
DR CTD; 84128; -.
DR ZFIN; ZDB-GENE-030616-5; wdr75.
DR eggNOG; KOG1963; Eukaryota.
DR GeneTree; ENSGT00390000006303; -.
DR HOGENOM; CLU_005417_2_0_1; -.
DR InParanoid; Q7ZVR1; -.
DR OrthoDB; 1437651at2759; -.
DR PhylomeDB; Q7ZVR1; -.
DR TreeFam; TF323469; -.
DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q7ZVR1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000040730; Expressed in blastula and 43 other tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:2000234; P:positive regulation of rRNA processing; IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..832
FT /note="WD repeat-containing protein 75"
FT /id="PRO_0000051431"
FT REPEAT 4..43
FT /note="WD 1"
FT REPEAT 47..86
FT /note="WD 2"
FT REPEAT 90..134
FT /note="WD 3"
FT REPEAT 148..187
FT /note="WD 4"
FT REPEAT 196..233
FT /note="WD 5"
FT REPEAT 239..278
FT /note="WD 6"
FT REPEAT 281..320
FT /note="WD 7"
FT REPEAT 326..364
FT /note="WD 8"
FT REPEAT 378..425
FT /note="WD 9"
FT REPEAT 432..474
FT /note="WD 10"
FT REPEAT 485..523
FT /note="WD 11"
FT REPEAT 527..567
FT /note="WD 12"
FT REPEAT 572..609
FT /note="WD 13"
FT REGION 704..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..785
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 390
FT /note="F -> I (in Ref. 1; CAD52133)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="E -> G (in Ref. 2; AAH45446)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 832 AA; 93936 MW; 37CA911EFA18D56B CRC64;
MVEKTDIRVV RCGGSKINFR PPIISHDSRF VLCVSGDSVK VYSTRTEEWL HNLQGHNNQV
TGIAFNPANQ LQVYSCSADG TVKLWDFIDG ILIKTFVIGY PLYSLYVSEK HEGVIFLIVS
MVTDSNNESF QLVAVHLPKS AEQEVEAKEL STVASKISPN PSCTAFGRGG EFIAFSRHLQ
LNVYFFRKQK TYSFSLKATD KKAGKNAFTC VACHPTDDCI ASGHEDGKIR LWRNFNHKKE
YTYSTKHWHH DAVNHLCFTP EGSNLLSGGI ESVLVQWQYG DMSKKEFLPR LGGSISHVSA
SADGQLFCTA HSDNKISIIE SSFKVSGLIQ GLVRGDAVST DLMIDPRSKA LVLNGKPGHL
QFYSLLRDKH LYNLDIVQQE YIYEAGLDQF EVVKAVFDVK GSWLATVEER GHKTSDLEFF
LKLWAFDETT QSFVLNTTVT EAHSERITSM CFSSSEETTM LVTTALDGQF KAWCQTADAQ
QAQNYWSCDF VGSYHNLKPK NCCFSADGSI LAVSFQEVLT LWSPETWELL TTLCQPPGEI
RDLCFGRLSC SKYLLSTTTK NLLCCWNLLT CALEWSTSVD VSRLQSDPLS ENVAAFSFES
KHTHLFVFKP SEPRPLFSQR YVCLERVDRA VFVPREEPFN SCDESCQWLN RSQLYFLTHN
MDLLTFSSAT EEDRMLSSSK RLVIDESVAV TPFYLLLGRH RKQQHKLNTE TQEPADKPQH
TQGSVTIKQL LHTPAHVLPA ASVLCSMFVR SLLISNTGVR EEMDSSEQEM DSEKEEEESE
EEMEACDGQQ ELRAQGSVDE QKPKLSKAQE RELKSLRKTD FSWMTSLIDS KP
