ID   WDR75_XENLA             Reviewed;         832 AA.
AC   Q6DFC6;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=WD repeat-containing protein 75;
GN   Name=wdr75;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC       of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC       transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q8IWA0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q8IWA0}.
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DR   EMBL; BC076813; AAH76813.1; -; mRNA.
DR   RefSeq; NP_001086564.1; NM_001093095.1.
DR   AlphaFoldDB; Q6DFC6; -.
DR   SMR; Q6DFC6; -.
DR   DNASU; 446399; -.
DR   GeneID; 446399; -.
DR   KEGG; xla:446399; -.
DR   CTD; 446399; -.
DR   Xenbase; XB-GENE-5864484; wdr75.L.
DR   OMA; WILNTRI; -.
DR   OrthoDB; 1437651at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 446399; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..832
FT                   /note="WD repeat-containing protein 75"
FT                   /id="PRO_0000051432"
FT   REPEAT          4..43
FT                   /note="WD 1"
FT   REPEAT          47..86
FT                   /note="WD 2"
FT   REPEAT          90..131
FT                   /note="WD 3"
FT   REPEAT          145..184
FT                   /note="WD 4"
FT   REPEAT          193..230
FT                   /note="WD 5"
FT   REPEAT          236..275
FT                   /note="WD 6"
FT   REPEAT          278..317
FT                   /note="WD 7"
FT   REPEAT          323..361
FT                   /note="WD 8"
FT   REPEAT          375..424
FT                   /note="WD 9"
FT   REPEAT          431..477
FT                   /note="WD 10"
FT   REPEAT          490..528
FT                   /note="WD 11"
FT   REPEAT          532..572
FT                   /note="WD 12"
FT   REPEAT          577..614
FT                   /note="WD 13"
FT   REGION          764..798
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        765..795
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   832 AA;  94049 MW;  56A7BFA52C402A4F CRC64;
     MVSQCQIRVV RSGGSKLDYR RSVFSADGKY LICVSGDFIK VYSTSTEECI HALQGHRKLV
     TGIELNPKNH LQLYSCSLDG TIKLWDFTDG ILIKTFLIGC KFLSLYTSAT DDLVFAVTLK
     NNDSASSQLV SVKLPKSASQ ECEAKEISVI IEDVSHLPKC TAIGRQCLYV ASVKGVHLSI
     YYFKTKKSFR FSLKATSKKG ANNIFTVVAC HPSEDCIATG HMDGRIRLWR NFNHKKEYTY
     TSLHWHHDSV MDLAFSAQGT KLLSGGVESV LVQWPYGSEE KKEFLPRLGA AIEHISVSPH
     GTLYCTSHTD NKISIIDTSL KVSGIIQGLL KGTVVKTGLI VDPRSNALVL NGKPGHLQFY
     SLLNDRHLYN LDIVQQEFIH QAGLQYMDLV KASFSSTGRW LATVEELQGG EDSMDLEMQM
     KLWEYQDKSQ SFVLNTTINR PHEDHITSLC FRDEGNSEKE APTLVTTGKD GLFKVWMLNN
     NYDIYKQSSS WLCDFVGGYH KNQATNCCFS EDGSLLAVSF DEIITVWESS TWDLKQTFCQ
     PPGKIRNLCF GRMSCSKYLV ASTNNGFICC WNLLTCALEW RAQLDATVLQ PDPLSENIAV
     VSCSKRWSNL FLFQPSEPRP FYTQKNICQE KVQWAVFVPK EIPEFVKSES HQWLNKSQLY
     FLTEKQDLLT FSSKSTEERL TPLSKQLAVE ESLPVTPFHL LLGKKRQEEQ EKLDAQSVRA
     APSFHRGYQN SAIREVLHTP AHVLPPASVL CTVFVNSLLI SKKSQSTEES KEDEEMKSEH
     SEADSSDETE EMESQKRFPS AFSLDVAAML PKFQEKELRR IRRTDYSWIS SL