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WDR76_HUMAN
ID   WDR76_HUMAN             Reviewed;         626 AA.
AC   Q9H967; A0MNP5; Q05CI4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 161.
DE   RecName: Full=WD repeat-containing protein 76;
GN   Name=WDR76;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CUL4A AND/OR CUL4B, AND
RP   VARIANT ALA-153.
RX   PubMed=17041588; DOI=10.1038/ncb1490;
RA   Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.;
RT   "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
RT   and regulates histone methylation.";
RL   Nat. Cell Biol. 8:1277-1283(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-153.
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-153.
RC   TISSUE=Eye, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC       that it acts as a specific reader of 5hmC. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CUL4A and/or CUL4B.
CC       {ECO:0000269|PubMed:17041588}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; EF011624; ABK41114.1; -; mRNA.
DR   EMBL; AK023035; BAB14369.1; -; mRNA.
DR   EMBL; AK290933; BAF83622.1; -; mRNA.
DR   EMBL; AC018512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC023356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC025247; AAH25247.1; -; mRNA.
DR   EMBL; BC051855; AAH51855.1; -; mRNA.
DR   CCDS; CCDS10106.1; -.
DR   RefSeq; NP_001161413.1; NM_001167941.1.
DR   RefSeq; NP_079184.2; NM_024908.3.
DR   RefSeq; XP_005254737.1; XM_005254680.3.
DR   AlphaFoldDB; Q9H967; -.
DR   SMR; Q9H967; -.
DR   BioGRID; 123035; 374.
DR   IntAct; Q9H967; 26.
DR   MINT; Q9H967; -.
DR   STRING; 9606.ENSP00000263795; -.
DR   iPTMnet; Q9H967; -.
DR   PhosphoSitePlus; Q9H967; -.
DR   BioMuta; WDR76; -.
DR   DMDM; 313104049; -.
DR   EPD; Q9H967; -.
DR   jPOST; Q9H967; -.
DR   MassIVE; Q9H967; -.
DR   MaxQB; Q9H967; -.
DR   PaxDb; Q9H967; -.
DR   PeptideAtlas; Q9H967; -.
DR   PRIDE; Q9H967; -.
DR   ProteomicsDB; 81286; -.
DR   Antibodypedia; 52296; 77 antibodies from 21 providers.
DR   DNASU; 79968; -.
DR   Ensembl; ENST00000263795.11; ENSP00000263795.6; ENSG00000092470.12.
DR   GeneID; 79968; -.
DR   KEGG; hsa:79968; -.
DR   MANE-Select; ENST00000263795.11; ENSP00000263795.6; NM_024908.4; NP_079184.2.
DR   UCSC; uc001zti.3; human.
DR   CTD; 79968; -.
DR   DisGeNET; 79968; -.
DR   GeneCards; WDR76; -.
DR   HGNC; HGNC:25773; WDR76.
DR   HPA; ENSG00000092470; Tissue enhanced (bone marrow, lymphoid tissue).
DR   neXtProt; NX_Q9H967; -.
DR   OpenTargets; ENSG00000092470; -.
DR   PharmGKB; PA142670580; -.
DR   VEuPathDB; HostDB:ENSG00000092470; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   GeneTree; ENSGT00510000048144; -.
DR   InParanoid; Q9H967; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   PhylomeDB; Q9H967; -.
DR   TreeFam; TF314788; -.
DR   PathwayCommons; Q9H967; -.
DR   SignaLink; Q9H967; -.
DR   BioGRID-ORCS; 79968; 13 hits in 1084 CRISPR screens.
DR   ChiTaRS; WDR76; human.
DR   GenomeRNAi; 79968; -.
DR   Pharos; Q9H967; Tbio.
DR   PRO; PR:Q9H967; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q9H967; protein.
DR   Bgee; ENSG00000092470; Expressed in oocyte and 120 other tissues.
DR   ExpressionAtlas; Q9H967; baseline and differential.
DR   Genevisible; Q9H967; HS.
DR   GO; GO:0000792; C:heterochromatin; IMP:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0090734; C:site of DNA damage; IMP:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:UniProtKB.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..626
FT                   /note="WD repeat-containing protein 76"
FT                   /id="PRO_0000242691"
FT   REPEAT          311..352
FT                   /note="WD 1"
FT   REPEAT          358..400
FT                   /note="WD 2"
FT   REPEAT          402..441
FT                   /note="WD 3"
FT   REPEAT          446..485
FT                   /note="WD 4"
FT   REPEAT          493..533
FT                   /note="WD 5"
FT   REPEAT          535..565
FT                   /note="WD 6"
FT   REPEAT          590..626
FT                   /note="WD 7"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         153
FT                   /note="S -> A (in dbSNP:rs678084)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17041588"
FT                   /id="VAR_026862"
FT   VARIANT         614
FT                   /note="S -> G (in dbSNP:rs3742985)"
FT                   /id="VAR_026863"
SQ   SEQUENCE   626 AA;  69769 MW;  DC6DE3A59250EFA1 CRC64;
     MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ
     LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES
     NKLQPKRTAD AMNLSVDVES SQDGDSDEDT TPSLDFSGLS PYERKRLKNI SENADFFASL
     QLSESAARLR EMIEKRQPPK SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV
     ADETPLLPPG PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG
     MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS
     QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLAEDASTLI
     VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARRL
     NSRRSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH
     NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA
     MHPTRYILAG GNSSGKIHVF MNEKSC
 
 
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