ID   WDR76_PAPAN             Reviewed;         626 AA.
AC   A9X1C6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=WD repeat-containing protein 76;
GN   Name=WDR76;
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA   Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA   Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA   Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA   Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA   Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA   Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA   Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA   Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA   Tsipouri V., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC       that it acts as a specific reader of 5hmC. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CUL4A and/or CUL4B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; DP000543; ABY40821.1; -; Genomic_DNA.
DR   RefSeq; NP_001162443.1; NM_001168972.1.
DR   AlphaFoldDB; A9X1C6; -.
DR   SMR; A9X1C6; -.
DR   STRING; 9555.ENSPANP00000017416; -.
DR   GeneID; 100137438; -.
DR   KEGG; panu:100137438; -.
DR   CTD; 79968; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000028761; Unplaced.
DR   GO; GO:0000792; C:heterochromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090734; C:site of DNA damage; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..626
FT                   /note="WD repeat-containing protein 76"
FT                   /id="PRO_0000351093"
FT   REPEAT          311..352
FT                   /note="WD 1"
FT   REPEAT          358..400
FT                   /note="WD 2"
FT   REPEAT          402..441
FT                   /note="WD 3"
FT   REPEAT          446..485
FT                   /note="WD 4"
FT   REPEAT          493..533
FT                   /note="WD 5"
FT   REPEAT          535..565
FT                   /note="WD 6"
FT   REPEAT          590..626
FT                   /note="WD 7"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  69678 MW;  DF6E42F138713168 CRC64;
     MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPVQT TVLIKTAKVY LAPFSLSNYQ
     LDQLMCPKSL LEKNSNNEVA CKKTKIKKTC SRIIPPKMKT TSSKSESTLQ NSASAVHTES
     NKLQPKRTAD AMNLSVDVES SQDEDSDEDI TPGLDDFSGL SPYERKRLKN ISENADFFAS
     LQLSESAARL REIIEKRQPP KSKRKKPKRE NGVGCRRSMR LLKVDPSGVS LPATPTPPTL
     VADETPLLPP GPLEMTSENQ EDNERFKGFL HTWAGMNKPS SKNTEKGLSS IKSYRANLNG
     MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS
     QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLSEDASTLI
     VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARQL
     KSRGSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCVSS KIPLLTTIRH
     NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE CLVSVCSINA
     MHPTRYILAG GNSSGKIHVF MNEKSC