ID   WDR76_RHIFE             Reviewed;         630 AA.
AC   B2KIQ4;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=WD repeat-containing protein 76;
GN   Name=WDR76;
OS   Rhinolophus ferrumequinum (Greater horseshoe bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Rhinolophidae;
OC   Rhinolophinae; Rhinolophus.
OX   NCBI_TaxID=59479;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA   Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA   Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA   Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA   Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA   Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA   Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA   Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA   Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA   Tsipouri V., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC       that it acts as a specific reader of 5hmC. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CUL4A and/or CUL4B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACC69118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DP000730; ACC69118.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; B2KIQ4; -.
DR   SMR; B2KIQ4; -.
DR   Proteomes; UP000472240; Unplaced.
DR   GO; GO:0000792; C:heterochromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090734; C:site of DNA damage; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..630
FT                   /note="WD repeat-containing protein 76"
FT                   /id="PRO_0000351094"
FT   REPEAT          318..359
FT                   /note="WD 1"
FT   REPEAT          365..405
FT                   /note="WD 2"
FT   REPEAT          408..448
FT                   /note="WD 3"
FT   REPEAT          453..492
FT                   /note="WD 4"
FT   REPEAT          500..540
FT                   /note="WD 5"
FT   REPEAT          542..572
FT                   /note="WD 6"
FT   REPEAT          598..630
FT                   /note="WD 7"
FT   REGION          105..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   630 AA;  70085 MW;  2406591BA2DACE74 CRC64;
     MSGSCAAAEE KEGSRQRLQM KVNEYKENQN MSSVSLRSIQ KTVLEKTVKV CLVPFSLSNY
     KSGQFKLPKS LLDKNSKNEV ACKKYKKTEI KKACTRILTS KMEATASSKA ESTLQKSSID
     VHTENNQRQH KSTSDTVSLG VDTESSQDGD SDEDTTSSLD DFSGLSPYER KRLKNISENA
     NFFASLQLSE SAARLREMIE KRQPPETKRK KPKKKENETG CRRSMRLLNV DPSGVSLPVT
     PTEPTLVADE NPLLPPGPLE MIPENRDDNS ELFKEFLQTW AEVSKTSSKN IEKELSSLKT
     YKANLSGMVI SEDTVYKVTK GAIFSIAFHP SEIKTLVAAG AKSGQVGLWD LTHQPKEDGV
     YVFQPHSQPV SCLYFSPANP AHMLSLSYDG TLRCGDISSA VFEEVYRNER SSLSSFDFLA
     EDASTFIVGH WDGSISLVDR RTPGASYEKL ISSSLRKIRT VHVHPVQRQY FITAGLRDTH
     IYDARRLTPS GSQPLISLTE HTKSIASAYF SPLTGNRIVT TCADCKLRFF DSSCISSQIP
     LLTTIRHNTI TGRWLTRLRA VWDPKQEDCV IIGSMAHPRQ VEIFHETGEQ VHSFLGGECL
     VSVCSINAVH PTRYILAGGN SSGKIHVFMN