ID   WDR76_XENLA             Reviewed;         580 AA.
AC   Q4KLQ5;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=WD repeat-containing protein 76;
GN   Name=wdr76;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC       that it acts as a specific reader of 5hmC. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; BC099051; AAH99051.1; -; mRNA.
DR   RefSeq; NP_001090070.1; NM_001096601.1.
DR   AlphaFoldDB; Q4KLQ5; -.
DR   SMR; Q4KLQ5; -.
DR   BioGRID; 592925; 1.
DR   DNASU; 735144; -.
DR   GeneID; 735144; -.
DR   KEGG; xla:735144; -.
DR   CTD; 735144; -.
DR   Xenbase; XB-GENE-5868447; wdr76.S.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 735144; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..580
FT                   /note="WD repeat-containing protein 76"
FT                   /id="PRO_0000351095"
FT   REPEAT          269..310
FT                   /note="WD 1"
FT   REPEAT          316..356
FT                   /note="WD 2"
FT   REPEAT          359..399
FT                   /note="WD 3"
FT   REPEAT          404..443
FT                   /note="WD 4"
FT   REPEAT          450..490
FT                   /note="WD 5"
FT   REPEAT          500..544
FT                   /note="WD 6"
FT   REPEAT          548..580
FT                   /note="WD 7"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   580 AA;  65727 MW;  AD3C1DB2C322A8B3 CRC64;
     MEEKKETAQM TQETTPKDSR VIEGVRRSSR RSHAEPHSPK KAYEVRDRRQ KRSLERDQHE
     DGTPIKRARL PREQSSTRKH PIVLLSREIP EYHTETMPTP KKNYKLIPEQ VTELSEYEIE
     RLNNIKENAK FLQSLKLLET ASSLRSPPKK QNQTRGIKRE KQTKVERQPI IRRSMRLQRI
     DPSGAPLPNV IQPPEPLLEE HPVKPPGPLE MVPTNLKGDC ISVEEFLKTW ASTSKESLRS
     LKKQPSKDFK RYTACLQTMT LREETVAKVV QNRIFSVAIH PSESRTIVAA GDKWGQIGLW
     DLADLSGNDG VYVFEPHSRP ISCMSFSPVN SAQLFSLSYD GTVRCGDVCR SVFDEVYRDE
     QDSFSSFDYL SADCSVLIVS HWDSYLSVVD CRTPGTSCEQ RASLNMRSAR TTSVHPVNRD
     LCVVAGAGDV CIFDVRQLKK KAQPVLSLTG HSKSVASAYF SPVTGNRILT TCADDYIRVY
     DSSSLCSEAP LLTAFRHNNN TGRWLTRFRA VWDPKQESCF VVGSMARPRQ IEVYNESGKL
     EHSFWDSEHL GSVCSINAMH PTRNLLVGGN SSGRLHVFHD