WDR7_HUMAN
ID WDR7_HUMAN Reviewed; 1490 AA.
AC Q9Y4E6; A7E2C8; Q86UX5; Q86VP2; Q96PS7;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=WD repeat-containing protein 7;
DE AltName: Full=Rabconnectin-3 beta;
DE AltName: Full=TGF-beta resistance-associated protein TRAG;
GN Name=WDR7; Synonyms=KIAA0541, TRAG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12786944; DOI=10.1046/j.1365-2443.2003.00655.x;
RA Kawabe H., Sakisaka T., Yasumi M., Shingai T., Izumi G., Nagano F.,
RA Deguchi-Tawarada M., Takeuchi M., Nakanishi H., Takai Y.;
RT "A novel rabconnectin-3-binding protein that directly binds a GDP/GTP
RT exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent
RT exocytosis of neurotransmitter.";
RL Genes Cells 8:537-546(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RA Sanders S., Thorgeirsson S.S.;
RT "TRAG: a novel gene associated with TGF-beta resistance.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [4]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R., Ishikawa K.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-935 AND SER-1456, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y4E6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y4E6-2; Sequence=VSP_015274;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA25467.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY099325; AAM33134.1; -; mRNA.
DR EMBL; AF188125; AAL03983.1; -; mRNA.
DR EMBL; AB011113; BAA25467.2; ALT_INIT; mRNA.
DR EMBL; CH471096; EAW63038.1; -; Genomic_DNA.
DR EMBL; BC050352; AAH50352.1; -; mRNA.
DR EMBL; BC150282; AAI50283.1; -; mRNA.
DR CCDS; CCDS11962.1; -. [Q9Y4E6-1]
DR CCDS; CCDS11963.1; -. [Q9Y4E6-2]
DR PIR; T00272; T00272.
DR RefSeq; NP_056100.2; NM_015285.2. [Q9Y4E6-1]
DR RefSeq; NP_443066.2; NM_052834.2. [Q9Y4E6-2]
DR RefSeq; XP_006722494.1; XM_006722431.2.
DR RefSeq; XP_016881171.1; XM_017025682.1.
DR AlphaFoldDB; Q9Y4E6; -.
DR BioGRID; 116922; 68.
DR IntAct; Q9Y4E6; 5.
DR STRING; 9606.ENSP00000254442; -.
DR iPTMnet; Q9Y4E6; -.
DR PhosphoSitePlus; Q9Y4E6; -.
DR BioMuta; WDR7; -.
DR DMDM; 73920974; -.
DR EPD; Q9Y4E6; -.
DR jPOST; Q9Y4E6; -.
DR MassIVE; Q9Y4E6; -.
DR MaxQB; Q9Y4E6; -.
DR PaxDb; Q9Y4E6; -.
DR PeptideAtlas; Q9Y4E6; -.
DR PRIDE; Q9Y4E6; -.
DR ProteomicsDB; 86181; -. [Q9Y4E6-1]
DR ProteomicsDB; 86182; -. [Q9Y4E6-2]
DR Antibodypedia; 62690; 20 antibodies from 11 providers.
DR DNASU; 23335; -.
DR Ensembl; ENST00000254442.8; ENSP00000254442.3; ENSG00000091157.15. [Q9Y4E6-1]
DR Ensembl; ENST00000357574.7; ENSP00000350187.2; ENSG00000091157.15. [Q9Y4E6-2]
DR GeneID; 23335; -.
DR KEGG; hsa:23335; -.
DR MANE-Select; ENST00000254442.8; ENSP00000254442.3; NM_015285.3; NP_056100.2.
DR UCSC; uc002lgk.2; human. [Q9Y4E6-1]
DR CTD; 23335; -.
DR DisGeNET; 23335; -.
DR GeneCards; WDR7; -.
DR HGNC; HGNC:13490; WDR7.
DR HPA; ENSG00000091157; Low tissue specificity.
DR MIM; 613473; gene.
DR neXtProt; NX_Q9Y4E6; -.
DR OpenTargets; ENSG00000091157; -.
DR PharmGKB; PA37784; -.
DR VEuPathDB; HostDB:ENSG00000091157; -.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000155301; -.
DR HOGENOM; CLU_004362_1_0_1; -.
DR InParanoid; Q9Y4E6; -.
DR OMA; CEGKAVP; -.
DR OrthoDB; 84170at2759; -.
DR PhylomeDB; Q9Y4E6; -.
DR TreeFam; TF313196; -.
DR PathwayCommons; Q9Y4E6; -.
DR SignaLink; Q9Y4E6; -.
DR BioGRID-ORCS; 23335; 628 hits in 1106 CRISPR screens.
DR ChiTaRS; WDR7; human.
DR GenomeRNAi; 23335; -.
DR Pharos; Q9Y4E6; Tdark.
DR PRO; PR:Q9Y4E6; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9Y4E6; protein.
DR Bgee; ENSG00000091157; Expressed in endothelial cell and 199 other tissues.
DR ExpressionAtlas; Q9Y4E6; baseline and differential.
DR Genevisible; Q9Y4E6; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1490
FT /note="WD repeat-containing protein 7"
FT /id="PRO_0000051353"
FT REPEAT 17..56
FT /note="WD 1"
FT REPEAT 62..104
FT /note="WD 2"
FT REPEAT 156..199
FT /note="WD 3"
FT REPEAT 324..366
FT /note="WD 4"
FT REPEAT 404..443
FT /note="WD 5"
FT REPEAT 462..507
FT /note="WD 6"
FT REPEAT 558..597
FT /note="WD 7"
FT REPEAT 1351..1390
FT /note="WD 8"
FT REPEAT 1392..1432
FT /note="WD 9"
FT REGION 761..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 935
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1456
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 950..982
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_015274"
FT CONFLICT 54
FT /note="I -> V (in Ref. 2; AAL03983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1490 AA; 163810 MW; 626E876245696A1F CRC64;
MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV ELQINPRALL
FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR CIEFTKLACT HTGIQFYQFS
VGNQREGRLL CHGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSH RTQEDTVVAL
SVTGILKVWI VTSEISDMQD TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV
FDAGDYSLLC SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS GRLNIWNISD
TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI PNSNEPLKVT ASVYIPAHGR
LVCGREDGSI VIVPATQTAI VQLLQGEHML RRGWPPHRTL RGHRNKVTCL LYPHQVSARY
DQRYLISGGV DFSVIIWDIF SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH
SVGLLSLREK KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT LATNLLASEA
SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII QLLTEEASRP NTALISPENL
QKASGSSDKG GSFLTGKRAA VLFQQVKETI KENIKEHLLD DEEEDEEIMR QRREESDPEY
RSSKSKPLTL LEYNLTMDTA KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR
GGHMSLMLPG YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV AAPVVSARSD
ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG LDKFRPPLLE MLARRWQDRC
LEVREAAQAL LLAELRRIEQ AGRKEAIDAW APYLPQYIDH VISPGVTSEA AQTITTAPDA
SGPEAKVQEE EHDLVDDDIT TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE
IEPPKLLTRP RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD SARSARHALS
LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA RAKGEILRVI EILIEKMPTD
VVDLLVEVMD IIMYCLEGSL VKKKGLQECF PAICRFYMVS YYERNHRIAV GARHGSVALY
DIRTGKCQTI HGHKGPITAV AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ
LRCIKTYQVP PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV
