WDR7_MOUSE
ID WDR7_MOUSE Reviewed; 1489 AA.
AC Q920I9; Q059Q1; Q3U440; Q80TY3; Q920J0;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=WD repeat-containing protein 7;
DE AltName: Full=TGF-beta resistance-associated protein TRAG;
GN Name=Wdr7; Synonyms=Kiaa0541, Trag;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=129/SvJ; TISSUE=Brain;
RA Sanders S., Thorgeirsson S.S.;
RT "TRAG: a novel gene associated with TGF-beta resistance.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-1489 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-935 AND SER-1455, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q920I9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q920I9-2; Sequence=VSP_015275;
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DR EMBL; AF188123; AAL03981.1; -; mRNA.
DR EMBL; AF188124; AAL03982.1; -; mRNA.
DR EMBL; AK154451; BAE32595.1; -; mRNA.
DR EMBL; CH466528; EDL09715.1; -; Genomic_DNA.
DR EMBL; BC125573; AAI25574.1; -; mRNA.
DR EMBL; BC137785; AAI37786.1; -; mRNA.
DR EMBL; AK122304; BAC65586.1; -; mRNA.
DR CCDS; CCDS50307.1; -. [Q920I9-1]
DR CCDS; CCDS89260.1; -. [Q920I9-2]
DR RefSeq; NP_001014981.1; NM_001014981.1. [Q920I9-1]
DR RefSeq; XP_006525540.1; XM_006525477.3.
DR AlphaFoldDB; Q920I9; -.
DR BioGRID; 222341; 11.
DR IntAct; Q920I9; 4.
DR MINT; Q920I9; -.
DR STRING; 10090.ENSMUSP00000072509; -.
DR iPTMnet; Q920I9; -.
DR PhosphoSitePlus; Q920I9; -.
DR SwissPalm; Q920I9; -.
DR EPD; Q920I9; -.
DR jPOST; Q920I9; -.
DR MaxQB; Q920I9; -.
DR PaxDb; Q920I9; -.
DR PeptideAtlas; Q920I9; -.
DR PRIDE; Q920I9; -.
DR ProteomicsDB; 297552; -. [Q920I9-1]
DR ProteomicsDB; 297553; -. [Q920I9-2]
DR Antibodypedia; 62690; 20 antibodies from 11 providers.
DR DNASU; 104082; -.
DR Ensembl; ENSMUST00000072726; ENSMUSP00000072509; ENSMUSG00000040560. [Q920I9-1]
DR Ensembl; ENSMUST00000236879; ENSMUSP00000158252; ENSMUSG00000040560. [Q920I9-2]
DR GeneID; 104082; -.
DR KEGG; mmu:104082; -.
DR UCSC; uc008fea.2; mouse. [Q920I9-1]
DR UCSC; uc008feb.2; mouse. [Q920I9-2]
DR CTD; 23335; -.
DR MGI; MGI:1860197; Wdr7.
DR VEuPathDB; HostDB:ENSMUSG00000040560; -.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000155301; -.
DR HOGENOM; CLU_004362_1_0_1; -.
DR InParanoid; Q920I9; -.
DR OMA; CEGKAVP; -.
DR OrthoDB; 84170at2759; -.
DR PhylomeDB; Q920I9; -.
DR TreeFam; TF313196; -.
DR BioGRID-ORCS; 104082; 23 hits in 72 CRISPR screens.
DR ChiTaRS; Wdr7; mouse.
DR PRO; PR:Q920I9; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q920I9; protein.
DR Bgee; ENSMUSG00000040560; Expressed in superior cervical ganglion and 222 other tissues.
DR ExpressionAtlas; Q920I9; baseline and differential.
DR Genevisible; Q920I9; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1489
FT /note="WD repeat-containing protein 7"
FT /id="PRO_0000051354"
FT REPEAT 17..56
FT /note="WD 1"
FT REPEAT 62..104
FT /note="WD 2"
FT REPEAT 156..199
FT /note="WD 3"
FT REPEAT 324..366
FT /note="WD 4"
FT REPEAT 404..443
FT /note="WD 5"
FT REPEAT 462..507
FT /note="WD 6"
FT REPEAT 558..597
FT /note="WD 7"
FT REPEAT 1350..1389
FT /note="WD 8"
FT REPEAT 1391..1431
FT /note="WD 9"
FT REGION 754..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 935
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1455
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 950..981
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693553,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_015275"
FT CONFLICT 116
FT /note="F -> L (in Ref. 2; BAE32595)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="R -> H (in Ref. 1; AAL03981/AAL03982)"
FT /evidence="ECO:0000305"
FT CONFLICT 566
FT /note="I -> V (in Ref. 2; BAE32595)"
FT /evidence="ECO:0000305"
FT CONFLICT 579
FT /note="C -> S (in Ref. 1; AAL03981/AAL03982)"
FT /evidence="ECO:0000305"
FT CONFLICT 938
FT /note="P -> A (in Ref. 1; AAL03981/AAL03982 and 5;
FT BAC65586)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1489 AA; 163450 MW; 444A5509758C9E63 CRC64;
MAGNSLVLPI VLWGRKAPTH CISSILLTDD GGTIVTGCHD GQICLWDVSV ELEVNPRALL
FGHTASITCL SKACASGDKR YTVSASANGE MCLWDVNDGR CIEFTKLACT HTGIQFYQFS
VGNQQEGRLL CHGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSQ RTQEDTVVAL
SVTGILKVWI VTSEMSGMQD TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV
FDAGDYSLLC SGPSENGQTW TGGDFVSADK VIIWTENGQS YIYKLPASCL PASDSFRSDV
GKAVENLIPP VQHSLLDQKD KELVICPPVT RFFYGCKEYL HKLLIQGDSS GRLNIWNIAD
IAEKQEADEG LKMTTCISLQ EAFDKLKPCP AGIIDQLSVI PNSNEPLKVT ASVYIPAHGR
LVCGREDGSI IIVPATQTAI VQLLQGEHML RRGWPPHRTL RGHRNKVTCL LYPHQVSARY
DQRYLISGGV DFSVIIWDIF SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH
SVGLLSLREK KCIMLASRHL FPIQVIKWRP SDDYLVVGCT DGSVYVWQMD TGALDRCAMG
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT LATNLLASEA
SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII QLLTEEASRP NTALISPENL
QKASGSSDKG GSFLTGKRAA VLFQQVKETI KENIKEHLLD EEEDEEEARR QSREDSDPEY
RASKSKPLTL LEYNLTMDTA KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR
GGHMSLMLPG YNQAAGKLLH AKAEVGRKLP AAEGVGKGTY TVSRAVTTQH LLSIISLANT
LMSMTNATFI GDHMKKGPTR PPRPGTPDLS KARDSPPPSS NIVQGQIKQA AAPVVSARSD
ADHSGSDSAS PALPTCFLVN EGWSQLAAMH CVMLPDLLGL ERFRPPLLEM LARRWQDRCL
EVREAAQALL LAELRRIEQA GRKETIDTWA PYLPQYMDHV ISPGVTAEAM QTMAAAPDAS
GPEAKVQEEE HDLVDDDITA GCLSSVPQMK KISTSYEERR KQATAIVLLG VIGAEFGAEI
EPPKLLTRPR SSSQIPEGFG LTSGGSNYSL ARHTCKALTY LLLQPPSPKL PPHSTIRRTA
TDLIGRGFTV WEPYMDVSAV LMGLLELCAD AEKQLANITM GLPLSPAADS ARSARHALSL
IATARPPAFI TTIAKEVHRH TALAANTQSQ QSIHTTTLAR AKGEILRVIE ILIEKMPTDV
VDLLVEVMDI IMYCLEGSLV KKKGLQECFP AICRFYMVSY YERSHRIAVG ARHGSVALYD
IRTGKCQTIH GHKGPITAVS FAPDGRYLAT YSNTDSHISF WQMNTSLLGS IGMLNSAPQL
RCIKTYQVPP VQPASPGSHN ALKLARLIWT SNRNVILMAH DGKEHRFMV
