ID   WDR7_RAT                Reviewed;        1488 AA.
AC   Q9ERH3; Q920I8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=WD repeat-containing protein 7;
DE   AltName: Full=TGF-beta resistance-associated protein TRAG;
GN   Name=Wdr7; Synonyms=Trag;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RA   Sanders S., Thorgeirsson S.S.;
RT   "TRAG: a novel gene associated with TGF-beta resistance.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ERH3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ERH3-2; Sequence=VSP_015276;
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DR   EMBL; AF192379; AAL03984.1; -; mRNA.
DR   EMBL; AF305813; AAG31140.1; -; mRNA.
DR   RefSeq; NP_076465.1; NM_023975.1. [Q9ERH3-1]
DR   RefSeq; XP_008770393.1; XM_008772171.2. [Q9ERH3-1]
DR   RefSeq; XP_017456520.1; XM_017601031.1. [Q9ERH3-2]
DR   AlphaFoldDB; Q9ERH3; -.
DR   BioGRID; 249358; 4.
DR   IntAct; Q9ERH3; 2.
DR   MINT; Q9ERH3; -.
DR   STRING; 10116.ENSRNOP00000025325; -.
DR   CarbonylDB; Q9ERH3; -.
DR   iPTMnet; Q9ERH3; -.
DR   PhosphoSitePlus; Q9ERH3; -.
DR   SwissPalm; Q9ERH3; -.
DR   jPOST; Q9ERH3; -.
DR   PaxDb; Q9ERH3; -.
DR   PRIDE; Q9ERH3; -.
DR   Ensembl; ENSRNOT00000025325; ENSRNOP00000025325; ENSRNOG00000018387. [Q9ERH3-1]
DR   Ensembl; ENSRNOT00000110066; ENSRNOP00000082010; ENSRNOG00000018387. [Q9ERH3-2]
DR   GeneID; 66031; -.
DR   KEGG; rno:66031; -.
DR   UCSC; RGD:619836; rat. [Q9ERH3-1]
DR   CTD; 23335; -.
DR   RGD; 619836; Wdr7.
DR   eggNOG; KOG4155; Eukaryota.
DR   GeneTree; ENSGT00940000155301; -.
DR   HOGENOM; CLU_004362_1_0_1; -.
DR   InParanoid; Q9ERH3; -.
DR   OMA; CEGKAVP; -.
DR   OrthoDB; 84170at2759; -.
DR   PhylomeDB; Q9ERH3; -.
DR   TreeFam; TF313196; -.
DR   PRO; PR:Q9ERH3; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000018387; Expressed in Ammon's horn and 19 other tissues.
DR   Genevisible; Q9ERH3; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:RGD.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..1488
FT                   /note="WD repeat-containing protein 7"
FT                   /id="PRO_0000051355"
FT   REPEAT          17..56
FT                   /note="WD 1"
FT   REPEAT          62..104
FT                   /note="WD 2"
FT   REPEAT          156..199
FT                   /note="WD 3"
FT   REPEAT          324..366
FT                   /note="WD 4"
FT   REPEAT          404..443
FT                   /note="WD 5"
FT   REPEAT          462..507
FT                   /note="WD 6"
FT   REPEAT          558..597
FT                   /note="WD 7"
FT   REPEAT          1349..1388
FT                   /note="WD 8"
FT   REPEAT          1390..1430
FT                   /note="WD 9"
FT   REGION          761..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          911..947
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..947
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         935
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4E6"
FT   MOD_RES         1454
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4E6"
FT   VAR_SEQ         950..980
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_015276"
SQ   SEQUENCE   1488 AA;  163191 MW;  A675E5A2F3C09803 CRC64;
     MAGNSLVLPI VLWGRKAPTH CISSILLTDD GGTIVTGCHD GQICLWDLSE ELEVNPRALL
     FGHTAAITCL SKACASGDKQ YTVSASANGE MCLWDVNDGR CIEFTKLACT HTGIQFYQFS
     VGNQREGRLL CHGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSH RTQEDTVVAL
     SVTGILKVWI VTSEISGLQD TEPIFEEESK PIYCQNCQSL SFCAFTQRSL LVVCSKYWRV
     FDAGDYSLLC SGPSEDGQTW TGGDFVSADK VIIWTENGQS YIYKLPASCL PASDSFRSDV
     GKAVENLIPP VQHSLLDQKD RELVICPPVT RFFYGCKEYL HKLLIQGDSS GRLSIWNIAD
     IADKQEANEG LKTTTCISLQ DAFDKLKPCP AGIIDQLSVI PNSNEPLKVT ASVYIPAHGR
     LVCGREDGSI IIVPATQTAI VQLLQGEHML RRGWPPHRTL RGHRNKVTCL LYPHQVSARY
     DQRYLISGGV DFSVIIWDIF SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCVCSVASDH
     SVGLLSLREK KCIMLASRHL FPIQVIKWRP SDDYLVVGCT DGSVCVWQMD TGALDRCAMG
     ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT LATNLLASEA
     SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII QLLTEEASRP NTALISPENL
     QKASGSSDKG GSFLTGKRAA VLFQQVKETI KENIKEHLLD EEEDEEEVMR QRREESDPEY
     RASKSKPLTL LEYNLTMDTA KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR
     GGHMSLMLPG YNQAAGKLLQ AKAEAGRKGP ATESVGKGTY TVSRAVTTQH LLSIISLANT
     LMSMTNATFI GDHMKKGPTR PPRPGTPDLS KARDSPPASS NIVQGQIKQA AAPVSARSAA
     DHSGSASASP ALRTCFLVNE GWSQLAAMHC VMLPDLLGLG KFRPPLLEML ARRWQDRCLE
     VREAAQALLL AELRRIEQAG RKETIDTWAP YLPQYMDHVI SPGVTAEAMQ TMAAAPDASG
     PEAKVQEEEH DLVDDDITTG CLSSVPQMKK MSTSYEERRK QATAIVLLGV IGAEFGAEIE
     PPKLLTRPRS SSQIPEGFGL TSGGSNYSLA RHTCKALTFL LLQPPSPKLP PHSTIRRTAI
     DLIGRGFTVW EPYMDVSAVL MGLLELCADA EKQLANITMG LPLSPAADSA RSARHALSLI
     ATARPPAFIT TIAKEVHRHT ALAANTQSQQ SIHTTTLARA KGEILRVIEI LIEKMPTDVV
     DLLVEVMDII MYCLEGSLVK KKGLQECFPA ICRFYMVSYY ERSHRIAVGA RHGSVALYDI
     RTGKCQTIHG HKGPITAVSF APDGRYLATY SNTDSHISFW QMNTSLLGSI GMLNSAPQLR
     CIKTYQVPPV QPASPGSHNA LRLARLIWTS NRNVILMAHD GKEHRFMV