ID   WDR82_DANRE             Reviewed;         313 AA.
AC   Q6NV31; Q803V6;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=WD repeat-containing protein 82 {ECO:0000305};
DE   AltName: Full=Protein word of mouth;
GN   Name=wdr82; Synonyms=wom; ORFNames=zgc:55453;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory component of the SET1 complex implicated in the
CC       tethering of this complex to transcriptional start sites of active
CC       genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via
CC       recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-
CC       terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part
CC       of a transcription termination checkpoint that promotes transcription
CC       termination of long non-coding RNAs (lncRNAs).
CC       {ECO:0000250|UniProtKB:Q6UXN9}.
CC   -!- SUBUNIT: Component of the SET1 complex. {ECO:0000250|UniProtKB:Q6UXN9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6UXN9}.
CC       Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with
CC       chromatin (By similarity). Recruited at sites of high RNA polymerase II
CC       occupancy (By similarity). {ECO:0000250|UniProtKB:Q6UXN9,
CC       ECO:0000250|UniProtKB:Q8BFQ4}.
CC   -!- SIMILARITY: Belongs to the WD repeat SWD2 family. {ECO:0000305}.
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DR   EMBL; BC044174; AAH44174.1; -; mRNA.
DR   EMBL; BC068335; AAH68335.1; -; mRNA.
DR   RefSeq; NP_001159740.1; NM_001166268.1.
DR   AlphaFoldDB; Q6NV31; -.
DR   SMR; Q6NV31; -.
DR   STRING; 7955.ENSDARP00000019685; -.
DR   PaxDb; Q6NV31; -.
DR   PRIDE; Q6NV31; -.
DR   Ensembl; ENSDART00000007353; ENSDARP00000019685; ENSDARG00000014083.
DR   GeneID; 321614; -.
DR   KEGG; dre:321614; -.
DR   CTD; 80335; -.
DR   ZFIN; ZDB-GENE-030131-333; wdr82.
DR   eggNOG; KOG1446; Eukaryota.
DR   GeneTree; ENSGT00530000063965; -.
DR   HOGENOM; CLU_044117_0_0_1; -.
DR   InParanoid; Q6NV31; -.
DR   OMA; CVLNGDH; -.
DR   OrthoDB; 1146727at2759; -.
DR   PhylomeDB; Q6NV31; -.
DR   TreeFam; TF313497; -.
DR   PRO; PR:Q6NV31; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000014083; Expressed in testis and 29 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; IBA:GO_Central.
DR   GO; GO:0110064; P:lncRNA catabolic process; ISS:UniProtKB.
DR   GO; GO:0032785; P:negative regulation of DNA-templated transcription, elongation; ISS:UniProtKB.
DR   GO; GO:0140744; P:negative regulation of lncRNA transcription; ISS:UniProtKB.
DR   GO; GO:0071027; P:nuclear RNA surveillance; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037867; Swd2/WDR82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19861; PTHR19861; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Transcription termination; WD repeat.
FT   CHAIN           1..313
FT                   /note="WD repeat-containing protein 82"
FT                   /id="PRO_0000279688"
FT   REPEAT          19..58
FT                   /note="WD 1"
FT   REPEAT          105..144
FT                   /note="WD 2"
FT   REPEAT          146..184
FT                   /note="WD 3"
FT   REPEAT          192..231
FT                   /note="WD 4"
FT   REPEAT          237..276
FT                   /note="WD 5"
FT   REPEAT          280..313
FT                   /note="WD 6"
FT   CONFLICT        246
FT                   /note="S -> P (in Ref. 1; AAH44174)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  35001 MW;  78D7066811AF2888 CRC64;
     MKLTDSVLRS FRVAKVFREN SDKINCFDFS SNGETVISSS DDDSIVLYDC QEGKPKRTLY
     SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHNKRV VALSMSPVDD
     TFISGSLDKT IRLWDLRSPN CQGLMHLQGK PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD
     KGPFATFKLQ YERTCEWTGL KFSNDGKLIL VSTNGGTLRV LDAFKGAVLH SFGGYNNSKG
     VILEASFTPD SQFIMIGSED GKIHVWNAES GMKVALLDGK HTGPVTCLQF NPKFMTFASA
     CSNMAFWLPT IDD