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WDR82_DROME
ID   WDR82_DROME             Reviewed;         317 AA.
AC   Q9VLN1;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 172.
DE   RecName: Full=WD repeat-containing protein 82 {ECO:0000250|UniProtKB:Q6UXN9};
GN   Name=Wdr82 {ECO:0000303|PubMed:26577379, ECO:0000312|FlyBase:FBgn0032030};
GN   ORFNames=CG17293;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000312|EMBL:AAF52654.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000312|EMBL:AAF52654.1}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3] {ECO:0000312|EMBL:AAL39226.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA   Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA   Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA   Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN THE SET1 COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=21694722; DOI=10.1038/emboj.2011.194;
RA   Ardehali M.B., Mei A., Zobeck K.L., Caron M., Lis J.T., Kusch T.;
RT   "Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with
RT   role in transcription.";
RL   EMBO J. 30:2817-2828(2011).
RN   [5] {ECO:0000305}
RP   FUNCTION, AND IDENTIFICATION IN THE SET1 COMPLEX.
RX   PubMed=21875999; DOI=10.1128/mcb.06092-11;
RA   Mohan M., Herz H.M., Smith E.R., Zhang Y., Jackson J., Washburn M.P.,
RA   Florens L., Eissenberg J.C., Shilatifard A.;
RT   "The COMPASS family of H3K4 methylases in Drosophila.";
RL   Mol. Cell. Biol. 31:4310-4318(2011).
RN   [6]
RP   INTERACTION WITH MSL COMPLEX.
RX   PubMed=23295261; DOI=10.1038/nsmb.2477;
RA   Wang C.I., Alekseyenko A.A., LeRoy G., Elia A.E., Gorchakov A.A.,
RA   Britton L.M., Elledge S.J., Kharchenko P.V., Garcia B.A., Kuroda M.I.;
RT   "Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage
RT   compensation in Drosophila.";
RL   Nat. Struct. Mol. Biol. 20:202-209(2013).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH SU(SABLE).
RX   PubMed=26577379; DOI=10.1261/rna.048819.114;
RA   Brewer-Jensen P., Wilson C.B., Abernethy J., Mollison L., Card S.,
RA   Searles L.L.;
RT   "Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-
RT   inducible repetitive elements by a mechanism that involves transcription
RT   termination.";
RL   RNA 22:139-154(2016).
CC   -!- FUNCTION: Component of the SET1 complex that specifically di- and
CC       trimethylates 'Lys-4' of histone H3 (PubMed:21694722, PubMed:21875999).
CC       Together with su(sable), part of a transcription termination checkpoint
CC       that promotes transcription termination of aberrant RNAs and their
CC       subsequent degradation by the nuclear exosome (PubMed:26577379).
CC       {ECO:0000269|PubMed:21694722, ECO:0000269|PubMed:21875999,
CC       ECO:0000269|PubMed:26577379}.
CC   -!- SUBUNIT: Component of the SET1 complex, composed at least of the
CC       catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf
CC       and Dpy-30L1 (PubMed:21694722, PubMed:21875999). Interacts with male-
CC       specific lethal (MSL) histone acetyltransferase complex at least
CC       composed of mof, msl-1, msl-2 and msl-3 (PubMed:23295261). Interacts
CC       with su(sable) (PubMed:26577379). {ECO:0000269|PubMed:21694722,
CC       ECO:0000269|PubMed:21875999, ECO:0000269|PubMed:23295261,
CC       ECO:0000269|PubMed:26577379}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21694722}.
CC   -!- SIMILARITY: Belongs to the WD repeat SWD2 family. {ECO:0000255}.
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DR   EMBL; AE014134; AAF52654.1; -; Genomic_DNA.
DR   EMBL; AY069081; AAL39226.1; -; mRNA.
DR   RefSeq; NP_609217.1; NM_135373.3.
DR   AlphaFoldDB; Q9VLN1; -.
DR   SMR; Q9VLN1; -.
DR   BioGRID; 60277; 28.
DR   IntAct; Q9VLN1; 4.
DR   STRING; 7227.FBpp0079266; -.
DR   PaxDb; Q9VLN1; -.
DR   PRIDE; Q9VLN1; -.
DR   DNASU; 34153; -.
DR   EnsemblMetazoa; FBtr0079650; FBpp0079266; FBgn0032030.
DR   GeneID; 34153; -.
DR   KEGG; dme:Dmel_CG17293; -.
DR   UCSC; CG17293-RA; d. melanogaster.
DR   CTD; 80335; -.
DR   FlyBase; FBgn0032030; Wdr82.
DR   VEuPathDB; VectorBase:FBgn0032030; -.
DR   eggNOG; KOG1446; Eukaryota.
DR   GeneTree; ENSGT00530000063965; -.
DR   HOGENOM; CLU_044117_0_0_1; -.
DR   InParanoid; Q9VLN1; -.
DR   OMA; CVLNGDH; -.
DR   OrthoDB; 1146727at2759; -.
DR   PhylomeDB; Q9VLN1; -.
DR   BioGRID-ORCS; 34153; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 34153; -.
DR   PRO; PR:Q9VLN1; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0032030; Expressed in eye disc (Drosophila) and 27 other tissues.
DR   Genevisible; Q9VLN1; DM.
DR   GO; GO:0035097; C:histone methyltransferase complex; IDA:FlyBase.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IDA:FlyBase.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IDA:FlyBase.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; IMP:FlyBase.
DR   GO; GO:0032785; P:negative regulation of DNA-templated transcription, elongation; IDA:UniProtKB.
DR   GO; GO:0071027; P:nuclear RNA surveillance; IDA:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037867; Swd2/WDR82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19861; PTHR19861; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Transcription termination; WD repeat.
FT   CHAIN           1..317
FT                   /note="WD repeat-containing protein 82"
FT                   /id="PRO_0000429380"
FT   REPEAT          21..60
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          107..146
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          148..186
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          194..233
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          238..278
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          282..317
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  35355 MW;  FAE08A606ED23CAD CRC64;
     MKIKLIDSVV RSFKVAKIFR ENTDKINAID FAPNGEHLIS CSEDDQIVIY DCEKGTQSRT
     VNSKKYGVDL IHFTHANNTA IHSSTKVDDT IRYLSLHDNK YLRYFPGHTK KVISLCISPV
     EDTFLSGSLD KTLRLWDLRS PNCQGLMHLS GRPIAAYDPE GLIFAAGVNS ESIKLYDLRS
     FDKGPFVTFK LNQEKECDWT GLKFSRDGKT ILISTNGSVI RLVDAFHGTP LQTFTGYPNN
     KGIPIEASFS PDSQFIFSGS TDGRVHIWNA DTGNKVSVLN GDHPGPVQCV QFNPKYMMLA
     SACTNMAFWL PTSEEGL
 
 
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