ID   WDR82_XENTR             Reviewed;         313 AA.
AC   Q6GL39;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=WD repeat-containing protein 82 {ECO:0000305};
GN   Name=wdr82; ORFNames=TEgg072c23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory component of the SET1 complex implicated in the
CC       tethering of this complex to transcriptional start sites of active
CC       genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via
CC       recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-
CC       terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part
CC       of a transcription termination checkpoint that promotes transcription
CC       termination of long non-coding RNAs (lncRNAs).
CC       {ECO:0000250|UniProtKB:Q6UXN9}.
CC   -!- SUBUNIT: Component of the SET1 complex. {ECO:0000250|UniProtKB:Q6UXN9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6UXN9}.
CC       Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with
CC       chromatin (By similarity). Recruited at sites of high RNA polymerase II
CC       occupancy (By similarity). {ECO:0000250|UniProtKB:Q6UXN9,
CC       ECO:0000250|UniProtKB:Q8BFQ4}.
CC   -!- SIMILARITY: Belongs to the WD repeat SWD2 family. {ECO:0000305}.
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DR   EMBL; CR761982; CAJ81468.1; -; mRNA.
DR   EMBL; BC074675; AAH74675.1; -; mRNA.
DR   RefSeq; NP_001004854.1; NM_001004854.1.
DR   RefSeq; XP_012816262.1; XM_012960808.2.
DR   AlphaFoldDB; Q6GL39; -.
DR   SMR; Q6GL39; -.
DR   STRING; 8364.ENSXETP00000006015; -.
DR   PaxDb; Q6GL39; -.
DR   DNASU; 448141; -.
DR   Ensembl; ENSXETT00000102806; ENSXETP00000089985; ENSXETG00000002765.
DR   GeneID; 448141; -.
DR   KEGG; xtr:448141; -.
DR   CTD; 80335; -.
DR   Xenbase; XB-GENE-1003225; wdr82.
DR   eggNOG; KOG1446; Eukaryota.
DR   eggNOG; KOG1747; Eukaryota.
DR   InParanoid; Q6GL39; -.
DR   OrthoDB; 1146727at2759; -.
DR   PhylomeDB; Q6GL39; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002765; Expressed in brain and 14 other tissues.
DR   ExpressionAtlas; Q6GL39; baseline.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; IBA:GO_Central.
DR   GO; GO:0110064; P:lncRNA catabolic process; ISS:UniProtKB.
DR   GO; GO:0032785; P:negative regulation of DNA-templated transcription, elongation; ISS:UniProtKB.
DR   GO; GO:0140744; P:negative regulation of lncRNA transcription; ISS:UniProtKB.
DR   GO; GO:0071027; P:nuclear RNA surveillance; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037867; Swd2/WDR82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19861; PTHR19861; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Transcription termination; WD repeat.
FT   CHAIN           1..313
FT                   /note="WD repeat-containing protein 82"
FT                   /id="PRO_0000279691"
FT   REPEAT          19..58
FT                   /note="WD 1"
FT   REPEAT          105..144
FT                   /note="WD 2"
FT   REPEAT          146..184
FT                   /note="WD 3"
FT   REPEAT          192..231
FT                   /note="WD 4"
FT   REPEAT          236..276
FT                   /note="WD 5"
FT   REPEAT          280..313
FT                   /note="WD 6"
SQ   SEQUENCE   313 AA;  35204 MW;  C4BA0630A369DCF7 CRC64;
     MKLTDNVLRS FRVAKVFREN SDKINCFDFS PTGETVISSS DDDSIVLYDC QEGKPKRTLY
     SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHSKRV VALSMSPVDD
     TFISGSLDKT IRLWDLRSPN CQGLMHLQGK PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD
     KGPFATFKMQ YDRTCEWTAL KFSNDGKLIL MSTNGGFLRL VDAFKGAVMH TFGGYNNSKA
     VTLEATFTPD SQFIMIGSED GKIHVWNCES GMKVAVLDGK HTGPITCLQF NPKFMTFTSA
     CSNMAFWLPT IDD