ID   WDR83_DICDI             Reviewed;         325 AA.
AC   Q54H44;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=WD repeat domain-containing protein 83 homolog;
DE   AltName: Full=Mitogen-activated protein kinase organizer 1 homolog;
DE            Short=MAPK organizer 1 homolog;
GN   Name=morg1; ORFNames=DDB_G0289711;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Molecular scaffold protein for various multimeric protein
CC       complexes. Acts as a module in the assembly of a multicomponent
CC       scaffold for the ERK pathway, linking ERK responses to specific
CC       agonists. Also involved in response to hypoxia (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MORG1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000148; EAL62567.1; -; Genomic_DNA.
DR   RefSeq; XP_636074.1; XM_630982.1.
DR   AlphaFoldDB; Q54H44; -.
DR   SMR; Q54H44; -.
DR   STRING; 44689.DDB0233741; -.
DR   PaxDb; Q54H44; -.
DR   EnsemblProtists; EAL62567; EAL62567; DDB_G0289711.
DR   GeneID; 8627284; -.
DR   KEGG; ddi:DDB_G0289711; -.
DR   dictyBase; DDB_G0289711; morg1.
DR   eggNOG; KOG0316; Eukaryota.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   InParanoid; Q54H44; -.
DR   OMA; MCWDIRT; -.
DR   PhylomeDB; Q54H44; -.
DR   Reactome; R-DDI-5674135; MAP2K and MAPK activation.
DR   PRO; PR:Q54H44; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..325
FT                   /note="WD repeat domain-containing protein 83 homolog"
FT                   /id="PRO_0000328182"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          54..94
FT                   /note="WD 2"
FT   REPEAT          96..135
FT                   /note="WD 3"
FT   REPEAT          166..205
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..291
FT                   /note="WD 6"
FT   REPEAT          292..325
FT                   /note="WD 7"
FT   REGION          157..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  36144 MW;  7F047EE337D5D607 CRC64;
     MVKISCNKVL SNHSGSVTVV KYNSDGGYCL SGSSDKSIKL YNVSKGSMIH SFEEHGYGIG
     DLVSTSDNKQ LFSCAEKQLY QWDIASGQVI RRFQNAHNDT ITSVCVNLDS TLLFSGSSDR
     LVKAWDLRTK SINPVQILDD AKDTITSIIV NEQTITHNHS HGHGHSHGNN NNNQPHTHTQ
     KEVITSSVDG CIRTYDVRMG TLVTYEDTIP ISSVSITKDK KCFIASCTDE TVKLIDIDSY
     ETLKEYKGHK NKVYKINSCS NFDDSLIISG SEDNDFYIYE LLSGKLLSKL SGHSNIITHV
     DSHPSKNQFI TSSTDCTIRI WDQSE