ID   WDR83_XENLA             Reviewed;         314 AA.
AC   Q3KQ62;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=WD repeat domain-containing protein 83;
DE   AltName: Full=Mitogen-activated protein kinase organizer 1;
DE            Short=MAPK organizer 1;
GN   Name=wdr83; Synonyms=morg1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Molecular scaffold protein for various multimeric protein
CC       complexes. Acts as a module in the assembly of a multicomponent
CC       scaffold for the ERK pathway, linking ERK responses to specific
CC       agonists. Also involved in response to hypoxia by acting as a negative
CC       regulator of HIF1A/HIF-1-alpha (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MORG1 family. {ECO:0000305}.
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DR   EMBL; BC106371; AAI06372.1; -; mRNA.
DR   RefSeq; NP_001089704.1; NM_001096235.1.
DR   RefSeq; XP_018106740.1; XM_018251251.1.
DR   AlphaFoldDB; Q3KQ62; -.
DR   SMR; Q3KQ62; -.
DR   BioGRID; 592548; 1.
DR   IntAct; Q3KQ62; 1.
DR   MaxQB; Q3KQ62; -.
DR   PRIDE; Q3KQ62; -.
DR   DNASU; 734767; -.
DR   GeneID; 734767; -.
DR   KEGG; xla:734767; -.
DR   CTD; 734767; -.
DR   Xenbase; XB-GENE-969402; wdr83.L.
DR   OMA; MCWDIRT; -.
DR   OrthoDB; 1090342at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 734767; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..314
FT                   /note="WD repeat domain-containing protein 83"
FT                   /id="PRO_0000235267"
FT   REPEAT          23..62
FT                   /note="WD 1"
FT   REPEAT          65..104
FT                   /note="WD 2"
FT   REPEAT          107..146
FT                   /note="WD 3"
FT   REPEAT          151..188
FT                   /note="WD 4"
FT   REPEAT          189..228
FT                   /note="WD 5"
FT   REPEAT          231..272
FT                   /note="WD 6"
FT   REPEAT          275..313
FT                   /note="WD 7"
SQ   SEQUENCE   314 AA;  34176 MW;  8ADC1660BD0B181B CRC64;
     MSFPAPKPKA PELPQKLQHK LECNQGAVRA VRFNVDGNYC MTCGSDKSLK LWNPHKGSLL
     KTYSGHGYEV LDTAGSCDNS QLCSCSSDKT VILWDVAQGQ VVRKFRGHAG KVNCVQFNEE
     ATVIISGSID SSIRCWDCRS RRPDAIQIMD EAKDGISSVK VSAHEILAGS VDGNLRRYDL
     RKGEMCADYL GSPITCVSFS QDSQCLLASS LDSTLRLLDK DTGELLGEYT GHQNLSYKLD
     SCLSEKDTHV LSCSEDGTVC FWDLVEGSLV LKLPVGKAVV QSLSFHPTEC CLLTASEGGV
     QVWRGASYEE EGGS