ID   WDR83_XENTR             Reviewed;         314 AA.
AC   Q5XGI5;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=WD repeat domain-containing protein 83;
DE   AltName: Full=Mitogen-activated protein kinase organizer 1;
DE            Short=MAPK organizer 1;
GN   Name=wdr83; Synonyms=morg1; ORFNames=TGas070i04.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Molecular scaffold protein for various multimeric protein
CC       complexes. Acts as a module in the assembly of a multicomponent
CC       scaffold for the ERK pathway, linking ERK responses to specific
CC       agonists. Also involved in response to hypoxia by acting as a negative
CC       regulator of HIF1A/HIF-1-alpha (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MORG1 family. {ECO:0000305}.
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DR   EMBL; CR761781; CAJ83956.1; -; mRNA.
DR   EMBL; BC084454; AAH84454.1; -; mRNA.
DR   RefSeq; NP_001011071.1; NM_001011071.1.
DR   RefSeq; XP_012808940.1; XM_012953486.2.
DR   AlphaFoldDB; Q5XGI5; -.
DR   SMR; Q5XGI5; -.
DR   STRING; 8364.ENSXETP00000010561; -.
DR   PaxDb; Q5XGI5; -.
DR   DNASU; 496482; -.
DR   GeneID; 496482; -.
DR   KEGG; xtr:496482; -.
DR   CTD; 84292; -.
DR   Xenbase; XB-GENE-969395; wdr83.
DR   eggNOG; KOG0316; Eukaryota.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   InParanoid; Q5XGI5; -.
DR   OMA; IREYMAH; -.
DR   OrthoDB; 1090342at2759; -.
DR   PhylomeDB; Q5XGI5; -.
DR   TreeFam; TF314828; -.
DR   Reactome; R-XTR-5674135; MAP2K and MAPK activation.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005598; Expressed in neurula embryo and 13 other tissues.
DR   ExpressionAtlas; Q5XGI5; baseline.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..314
FT                   /note="WD repeat domain-containing protein 83"
FT                   /id="PRO_0000235268"
FT   REPEAT          23..62
FT                   /note="WD 1"
FT   REPEAT          65..104
FT                   /note="WD 2"
FT   REPEAT          107..146
FT                   /note="WD 3"
FT   REPEAT          151..188
FT                   /note="WD 4"
FT   REPEAT          189..228
FT                   /note="WD 5"
FT   REPEAT          231..272
FT                   /note="WD 6"
FT   REPEAT          275..313
FT                   /note="WD 7"
SQ   SEQUENCE   314 AA;  34364 MW;  DB71A2EB657BBB02 CRC64;
     MSFPAPKPKA PELPQKLQHK LECNQGAVRA VRFNVDGNYC MTCGSDKTLK LWNPHKGTLL
     KTYSGHGYEV LDTAGSYDNS QMCSCSSDKT VILWDVAQGQ VVRKFRGHAG KVNCVQFNEE
     ATVIMSGSID SSIRCWDCRS RRPEAIQILD EAKDGISSIK ISDHEILAGS VDGNLRRYDL
     RKGEMCADYL GSPITCVSFS QDSQCLLASS LDSTLRLLDK DTGELLGEYT GHQNHSYKLD
     SCLSEKDTHV LSCSEDGTVC FWDLVEGSLV LKLPVGKAAV QSLSFHPSEC CLLTASEGGV
     QLWRGASYEE EGGS