WDR86_HUMAN
ID WDR86_HUMAN Reviewed; 376 AA.
AC Q86TI4; B4DJF1; C9JAJ5; C9JXE3; Q3KNT1; Q6ZUS8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=WD repeat-containing protein 86;
GN Name=WDR86;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Subthalamic nucleus, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 53-376 (ISOFORM 3), AND VARIANT THR-355.
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=3;
CC IsoId=Q86TI4-3; Sequence=Displayed;
CC Name=1;
CC IsoId=Q86TI4-1; Sequence=VSP_039818;
CC Name=2;
CC IsoId=Q86TI4-2; Sequence=VSP_031725, VSP_031726;
CC Name=4;
CC IsoId=Q86TI4-4; Sequence=VSP_054908;
CC -!- MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI07126.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK125347; BAC86140.1; -; mRNA.
DR EMBL; AK296049; BAG58813.1; -; mRNA.
DR EMBL; AC005486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471173; EAW53997.1; -; Genomic_DNA.
DR EMBL; BC047921; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC107125; AAI07126.1; ALT_INIT; mRNA.
DR CCDS; CCDS5925.2; -. [Q86TI4-3]
DR CCDS; CCDS64805.1; -. [Q86TI4-2]
DR CCDS; CCDS64806.1; -. [Q86TI4-4]
DR RefSeq; NP_001271189.1; NM_001284260.1. [Q86TI4-4]
DR RefSeq; NP_001271190.1; NM_001284261.1. [Q86TI4-2]
DR RefSeq; NP_001271191.1; NM_001284262.1.
DR RefSeq; NP_938026.2; NM_198285.2. [Q86TI4-3]
DR AlphaFoldDB; Q86TI4; -.
DR SMR; Q86TI4; -.
DR BioGRID; 131548; 27.
DR IntAct; Q86TI4; 14.
DR STRING; 9606.ENSP00000419162; -.
DR iPTMnet; Q86TI4; -.
DR PhosphoSitePlus; Q86TI4; -.
DR BioMuta; WDR86; -.
DR DMDM; 308153536; -.
DR jPOST; Q86TI4; -.
DR PaxDb; Q86TI4; -.
DR PeptideAtlas; Q86TI4; -.
DR PRIDE; Q86TI4; -.
DR ProteomicsDB; 12112; -.
DR ProteomicsDB; 69702; -. [Q86TI4-3]
DR ProteomicsDB; 69703; -. [Q86TI4-1]
DR Antibodypedia; 18758; 77 antibodies from 16 providers.
DR DNASU; 349136; -.
DR Ensembl; ENST00000334493.11; ENSP00000335522.7; ENSG00000187260.16. [Q86TI4-3]
DR Ensembl; ENST00000469830.2; ENSP00000419162.2; ENSG00000187260.16. [Q86TI4-4]
DR Ensembl; ENST00000477459.5; ENSP00000417512.1; ENSG00000187260.16. [Q86TI4-2]
DR Ensembl; ENST00000628331.1; ENSP00000486705.1; ENSG00000187260.16. [Q86TI4-2]
DR GeneID; 349136; -.
DR KEGG; hsa:349136; -.
DR MANE-Select; ENST00000334493.11; ENSP00000335522.7; NM_198285.3; NP_938026.2.
DR UCSC; uc003wkb.3; human. [Q86TI4-3]
DR CTD; 349136; -.
DR GeneCards; WDR86; -.
DR HGNC; HGNC:28020; WDR86.
DR HPA; ENSG00000187260; Tissue enhanced (thyroid).
DR neXtProt; NX_Q86TI4; -.
DR OpenTargets; ENSG00000187260; -.
DR PharmGKB; PA145147619; -.
DR VEuPathDB; HostDB:ENSG00000187260; -.
DR eggNOG; KOG0274; Eukaryota.
DR GeneTree; ENSGT00940000161049; -.
DR HOGENOM; CLU_000288_57_14_1; -.
DR InParanoid; Q86TI4; -.
DR OMA; NKLMYTG; -.
DR OrthoDB; 988404at2759; -.
DR PhylomeDB; Q86TI4; -.
DR TreeFam; TF338411; -.
DR PathwayCommons; Q86TI4; -.
DR SignaLink; Q86TI4; -.
DR BioGRID-ORCS; 349136; 24 hits in 1061 CRISPR screens.
DR GenomeRNAi; 349136; -.
DR Pharos; Q86TI4; Tdark.
DR PRO; PR:Q86TI4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q86TI4; protein.
DR Bgee; ENSG00000187260; Expressed in right uterine tube and 107 other tissues.
DR ExpressionAtlas; Q86TI4; baseline and differential.
DR Genevisible; Q86TI4; HS.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR044715; WDR86-like.
DR PANTHER; PTHR44489; PTHR44489; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..376
FT /note="WD repeat-containing protein 86"
FT /id="PRO_0000320674"
FT REPEAT 13..52
FT /note="WD 1"
FT REPEAT 55..94
FT /note="WD 2"
FT REPEAT 95..132
FT /note="WD 3"
FT REPEAT 135..188
FT /note="WD 4"
FT REPEAT 191..232
FT /note="WD 5"
FT REPEAT 234..272
FT /note="WD 6"
FT REPEAT 274..310
FT /note="WD 7"
FT REPEAT 313..350
FT /note="WD 8"
FT VAR_SEQ 1..128
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031725"
FT VAR_SEQ 54
FT /note="Q -> QGRPSHSLPDLFAAAHRPQTADPSSCARRPLSRSPAPAHPGTLAEER
FT LSGPSIWLLSARQGRVPCGLFVANCALLLAFPVDDSHSNNRRLLRASGAEKCAVVTLCY
FT PTYRRGNRLG (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039818"
FT VAR_SEQ 243..376
FT /note="LVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGD
FT ACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPP
FT PMRSLSRLFSNKVGCAAAPLQPA -> CSRAAGTLAPGPSTRSLESCGGCSGATHSSST
FT ASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRWAAPPRPCSRPDP
FT AGPLQTPAQTPSGSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSLVARRRWE
FT RECSPWGPPPFPF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031726"
FT VAR_SEQ 243..376
FT /note="LVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGD
FT ACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPP
FT PMRSLSRLFSNKVGCAAAPLQPA -> RERSGGLQSCPSCRPSLLLLAAGEPTRVLWQR
FT GQDRQVLAGRHRGVCAHVHGPQTQRERPQVPRGHLVHGQRGRLRPGLRRAVWRAAEGVP
FT GPHIHHQLHPGARPGALHRLARRRPAPLGRARAPRCPAAPSAHAQPLAALQQQGGLRRR
FT APAAGLIPRGPCRRQPRHPAAPRAPRPATRGGGARWPARGEERGSPGGRRARRRRLVFL
FT WWPGGAGSGSARPGDRPLFPFRVAPVLPPHP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054908"
FT VARIANT 355
FT /note="M -> T (in dbSNP:rs4141455)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_063633"
FT CONFLICT 54
FT /note="Q -> E (in Ref. 4; AAI07126)"
FT /evidence="ECO:0000305"
FT CONFLICT Q86TI4-4:182
FT /note="S -> R (in Ref. 1; BAC86140)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 40731 MW; 1911439E465CAB15 CRC64;
MGGGGSALRV CADHRGGINW LSLSPDGQRL LTGSEDGTAR LWSTADGQCC ALLQGHESYV
TFCQLEDEAA FTCSADCTIR RWDVLTGQCL QVYRGHTSIV NRILVANNQL FSSSYDRTAR
VWSVDKGQMS REFRGHRNCV LTLAYSAPWD LPSTPCAEEA AAGGLLVTGS TDGTAKVWQV
ASGCCHQTLR GHTGAVLCLV LDTPGHTAFT GSTDATIRAW DILSGEQLRV FREHRGSVIC
LELVNRLVYS GSADRTVKCW LADTGECVRT FTAHRRNVSA LKYHAGTLFT GSGDACARAF
DAQSGELRRV FRGHTFIINC IQVHGQVLYT ASHDGALRLW DVRGLRGAPR PPPPMRSLSR
LFSNKVGCAA APLQPA
