WDR87_HUMAN
ID WDR87_HUMAN Reviewed; 2873 AA.
AC Q6ZQQ6; Q9BWV9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=WD repeat-containing protein 87;
DE AltName: Full=Testis development protein NYD-SP11;
GN Name=WDR87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1350 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-1170 (ISOFORM 2).
RC TISSUE=Testis;
RA Sha J.H.;
RT "Cloning of new testis gene (NYD-SP11) related to testis development from
RT human testis cDNA library.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZQQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZQQ6-2; Sequence=VSP_030380;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK20167.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AAK20167.2; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC016582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK128826; BAC87627.1; -; mRNA.
DR EMBL; AY026504; AAK20167.2; ALT_SEQ; mRNA.
DR CCDS; CCDS46063.1; -. [Q6ZQQ6-1]
DR CCDS; CCDS74356.1; -. [Q6ZQQ6-2]
DR RefSeq; NP_114157.4; NM_031951.4.
DR BioGRID; 123800; 9.
DR IntAct; Q6ZQQ6; 6.
DR STRING; 9606.ENSP00000405012; -.
DR GlyGen; Q6ZQQ6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6ZQQ6; -.
DR PhosphoSitePlus; Q6ZQQ6; -.
DR BioMuta; WDR87; -.
DR EPD; Q6ZQQ6; -.
DR jPOST; Q6ZQQ6; -.
DR MassIVE; Q6ZQQ6; -.
DR PaxDb; Q6ZQQ6; -.
DR PeptideAtlas; Q6ZQQ6; -.
DR PRIDE; Q6ZQQ6; -.
DR ProteomicsDB; 68085; -. [Q6ZQQ6-1]
DR ProteomicsDB; 68086; -. [Q6ZQQ6-2]
DR Antibodypedia; 59216; 16 antibodies from 7 providers.
DR Ensembl; ENST00000303868.5; ENSP00000368025.3; ENSG00000171804.11.
DR GeneID; 83889; -.
DR KEGG; hsa:83889; -.
DR UCSC; uc010efu.3; human. [Q6ZQQ6-1]
DR CTD; 83889; -.
DR DisGeNET; 83889; -.
DR GeneCards; WDR87; -.
DR HGNC; HGNC:29934; WDR87.
DR HPA; ENSG00000171804; Tissue enriched (testis).
DR neXtProt; NX_Q6ZQQ6; -.
DR PharmGKB; PA145147633; -.
DR VEuPathDB; HostDB:ENSG00000171804; -.
DR eggNOG; ENOG502QTCV; Eukaryota.
DR HOGENOM; CLU_000543_0_0_1; -.
DR InParanoid; Q6ZQQ6; -.
DR TreeFam; TF338139; -.
DR PathwayCommons; Q6ZQQ6; -.
DR SignaLink; Q6ZQQ6; -.
DR BioGRID-ORCS; 83889; 16 hits in 1074 CRISPR screens.
DR GenomeRNAi; 83889; -.
DR Pharos; Q6ZQQ6; Tdark.
DR PRO; PR:Q6ZQQ6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZQQ6; protein.
DR Bgee; ENSG00000171804; Expressed in tibialis anterior and 18 other tissues.
DR ExpressionAtlas; Q6ZQQ6; baseline and differential.
DR Genevisible; Q6ZQQ6; HS.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..2873
FT /note="WD repeat-containing protein 87"
FT /id="PRO_0000314821"
FT REPEAT 108..146
FT /note="WD 1"
FT REPEAT 199..239
FT /note="WD 2"
FT REPEAT 242..283
FT /note="WD 3"
FT REPEAT 368..407
FT /note="WD 4"
FT REPEAT 415..460
FT /note="WD 5"
FT REPEAT 516..553
FT /note="WD 6"
FT REPEAT 565..604
FT /note="WD 7"
FT REGION 1049..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2199..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1099
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1197
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2204..2221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2241..2280
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2281..2307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2308..2335
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 42
FT /note="S -> SQALFKESRYPQNMPCVCYYFSDAHFFASLSWVTSNTKEI (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_030380"
FT VARIANT 496
FT /note="H -> Y (in dbSNP:rs12104280)"
FT /id="VAR_057638"
FT VARIANT 1583
FT /note="R -> Q (in dbSNP:rs6508750)"
FT /id="VAR_057639"
FT VARIANT 1885
FT /note="N -> K (in dbSNP:rs10422056)"
FT /id="VAR_057640"
FT VARIANT 2570
FT /note="H -> L (in dbSNP:rs10408510)"
FT /id="VAR_057641"
FT CONFLICT 135
FT /note="T -> S (in Ref. 3; AAK20167)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="T -> A (in Ref. 2; BAC87627)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="I -> T (in Ref. 3; AAK20167)"
FT /evidence="ECO:0000305"
FT CONFLICT 529
FT /note="K -> Q (in Ref. 3; AAK20167)"
FT /evidence="ECO:0000305"
FT CONFLICT 602
FT /note="G -> A (in Ref. 2; BAC87627 and 3; AAK20167)"
FT /evidence="ECO:0000305"
FT CONFLICT 817..818
FT /note="DR -> NS (in Ref. 3; AAK20167)"
FT /evidence="ECO:0000305"
FT CONFLICT 821
FT /note="E -> G (in Ref. 3; AAK20167)"
FT /evidence="ECO:0000305"
FT CONFLICT 939
FT /note="E -> G (in Ref. 3; AAK20167)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2873 AA; 333185 MW; E4BC3A63C503BAB4 CRC64;
MSSPRLIPLW KDLKLLLNDT INKSKQPSED PKNCLIVLSD RSQAVAWMKS KTEDMVEKRT
FSMTERLPPI QSMVHAGSFH ILVVYCGDLI LRLFGDHFRA FKPLGKVPCR FNISCLCYDP
EMKMLLSGIL GAVVTWVIEL GGTGLQIAHM VSMPGDELVQ DIVLNGPSGS LLALCETVVR
VLMHQGKGQL GEVKRFTSTS SGSSITCCFT CFDQGFLYAG NQAGEIQVWS LQQGHPLHSF
QAHQSGVICI RSRPEAHTLL TAGSDSLIKE WNLTSGSLLR RLELGEELYR LQFIDSITFF
CQTAHSFSLH RLPCFYSLFN VCGSAPQQLR RVCCGNNWFR ILCTTEDGLL RFVSPVTGDL
LVITWPFSIL DQAVDWAYDP GKEELFVATG SSEVLVFDTT RCPCPAKYLL GTSPNSQDFV
QCLAYGHFNL GRGLEGLIFS GHQSGVIRVL SQHSCARLEK FMHFGAVLAL STLSGGIFGG
QGNSLLCSYG MDDYVHLSEA VLDGVKVQLR PLASILSSCH LTHLILLPKS VGAITETNCL
RLWKFHDFLS SGSQNGLKFI ETLPLHLCAI TSFDVCLSLS LFVTGSADGS VRIWDFHGRL
IGILDSSLHF GPVCFANDRG DLLVTFNQSL YLVSCLKLLP PALLTRLSFM SISDEVLEVP
KPFIPSFFFS FETMFVPKYI YPGQAQQKLV GLEKLVNNRA IAFDHSVPHV IEEDEEGSPV
LLRSSMHYSL QDMEDWMQVS KRYQCHYVLP PQLQLTSWDG LNPYQILRYY FGHGREWLFA
PDCYIPNSVI RARLWPEGTP IYLQCNLHAP QRELEWDRSQ EFFFWHSRVR AISNTEYPKN
KEEDEHFLEM RLSKDVTYSV LTDGANRSWL GRKMSEITIN SMIETMLNIM VHASLLKYQC
CVGALGQIFA SYQVSPALRS ETARRLLNDT TNSNPLIREL AWEGLKRLGM ITHLFAMPLA
QGLMDKDERV RIKTLSLMAE IGIHSRTSLL QLTQKQETFR EMQQQMIGEE PLDHLLGMRA
TDLQILSTQV EQRLNENLTL SHRDEKPAFS LDVSMPSELK SSLKPPTVSE ESEVAIKPSK
GQRRGQAGVK KHSQKWLRGL KKTKERDSKQ MSTEPGLLED ESGTEAAPIE MEEASVYSQW
SSSTSVIKLS KDVDSQEKDI SKDHIALTLK RLQKIRDKRD KKATAQKLKK KHKKKGKEAK
VINEETTPPV MEQPVTKKVK IQGRGASGIS GRRSTAGDGS SWRDDLCRLM ALRISGSQTK
MSENLNAELV TFAQEMLVDR HPSWELFQEI CPLLKKESKV LLEDLDWDVV PPEKKPIFIQ
EGAIREDMIQ GVTQEVIRHK EVMPREEEQA QKKARDMLGL EETQVILKKG KKVIFLEPGN
VTMGKEISKK EEKKTFQKSP KQGRKAVQKE RKVGKIKREM TKEERDMSEE VEEMATLEEK
VVKQEGKLVM IERTPSWQDW KKAWDEWKQV HGETRKSWKA WKEEWEKRLL QEEEKLHQAG
EKLSPEEEML QEDKKLKWEE WKQVWENMLS SKSKEQQYKD EEEVTLEEEV SREGEEKEQQ
VTEEQRHIQE EHKWARIHRK RARAEKKRAQ EERKLAQEEE KLAQEERQLA QEERKLAQAY
VKITQDDREM AQAEGKFAQK EETLAQRGEK LSQEAEKLAQ KRKKLAKKWE KVAREEEKLA
KKGGKLAEVK NILAQKVEEL PQREQNLDWQ EKELAQELEE LEWDMEELSW KEEELNQEEG
KLVEEKKKLA EEEEALAWQR EKLSEEETKL AQEEELLIQE KEKLAQHKEK MPEEEERLGR
KREQLIEKKM KLAQKRERWI NSMEELTKNK MILYQKKNLA QEKKNLAQEK EKLAQRKENL
LYNKERLTHS KKQLVQVKNK LGMFNKILAQ VEEKLTQEKE TVIKKKEKLA ETEKKLVQVE
DSLAKKQEKL AQEKMKLALE KAMVQGKKRL RGELDIAKEE KALNLEMKRL AEEKMRLVEG
KETLSKGETP ETSRQRKMTQ VEQELFERKL SLEEKILLHE DRILAMEESE IAKGKLEFTR
GQRIFVQGQR KLAKASRKLI KKRESLSKEP AKLNKILKAL QKLTRDERKL TQEEIKMTKM
KRALFVKERR LSIEQSKLDI KEWDFSEKRS ELTKDEKKLA RKQRKLANKM RRMINKEEKM
TEEESKLARK HSEVILDDEE EGGIEEEEVI PFLKRRWRKR KEAKRGDKPK EKFSSQVDEV
ESEEHFSEEM ESLLDELEKQ ESLSSEEEEE REEEEEREEE EVREEEEERK EEEEGEEKQV
EKEEEEKKKK KKEKKKEEVQ EKEEVFEEKE EIMSEEETES LSDEEEEEES CSLEEEVDRE
KEILKKEKQF KLQEQRRKSL RGRERVLSIL RGVPHGKGRA IRLGVLKSPL KKLMSTALEM
KEKTPVPVPE KQISWEDKKA TVVEIPRKFL GTMDKEREVM GKYEPIPPHV LGTVLESQAQ
DLKTPFMSHI LRRTVEAEEL QHKPLGAWWK WFLQHPPLMG QTEVQLPLSQ IPAKEQHADV
SLSDVEWIRH VLERMEAGEQ LSRDGFHRLC QLLKDLASKG NLEWLHLAKH EAIVYRHRQA
LESQDTRISS RQSMSPKYLK VIPPIKAKEK ESWPKPLAVP TQKSPLATKR IPDPRAKNWH
LLGEPYRSER AQQISIAHKE MEMQYFYPAT RDIFPSAHAS VEKQTLALMF QKDFWDFKDK
RRFPKLPKLE KKTQPISKKK EELPLWETFV ALYHVLRMLQ QRYPKDSTAW MEQFYQLMDL
YQLKSPRIQK LLQELLMREE PQPQEIIYEE ALKATELVPG ERLFCCLFCG SSHTPRSPQE
FQGAVPLPWQ NCVRTILPVG IARYGILELA WKSLPEADLH LTKALTHTVA PTL
