WDR89_HUMAN
ID WDR89_HUMAN Reviewed; 387 AA.
AC Q96FK6;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=WD repeat-containing protein 89;
GN Name=WDR89; Synonyms=C14orf150; ORFNames=MSTP050;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RA Zhao B., Xu Y.Y., Liu Y.Q., Wang X.Y., Liu B., Ye J., Song L., Zhao Y.,
RA Cao H.Q., Zhao X.W., Gao Y., Liu L.S., Ding J.F., Gao R.L., Wu Q.Y.,
RA Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.;
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal liver;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AF115513; AAO06950.1; -; mRNA.
DR EMBL; BX248008; CAD62336.1; -; mRNA.
DR EMBL; AK095324; BAC04530.1; -; mRNA.
DR EMBL; BC010698; AAH10698.1; -; mRNA.
DR CCDS; CCDS9759.1; -.
DR RefSeq; NP_001008726.1; NM_001008726.2.
DR RefSeq; NP_001245201.1; NM_001258272.1.
DR RefSeq; NP_542397.1; NM_080666.3.
DR RefSeq; XP_011534687.1; XM_011536385.2.
DR AlphaFoldDB; Q96FK6; -.
DR SMR; Q96FK6; -.
DR BioGRID; 125208; 34.
DR IntAct; Q96FK6; 12.
DR STRING; 9606.ENSP00000378399; -.
DR iPTMnet; Q96FK6; -.
DR PhosphoSitePlus; Q96FK6; -.
DR BioMuta; WDR89; -.
DR DMDM; 74762654; -.
DR EPD; Q96FK6; -.
DR jPOST; Q96FK6; -.
DR MassIVE; Q96FK6; -.
DR MaxQB; Q96FK6; -.
DR PaxDb; Q96FK6; -.
DR PeptideAtlas; Q96FK6; -.
DR PRIDE; Q96FK6; -.
DR ProteomicsDB; 76537; -.
DR Antibodypedia; 38; 108 antibodies from 17 providers.
DR DNASU; 112840; -.
DR Ensembl; ENST00000267522.7; ENSP00000267522.3; ENSG00000140006.12.
DR Ensembl; ENST00000394942.2; ENSP00000378399.2; ENSG00000140006.12.
DR Ensembl; ENST00000620954.2; ENSP00000480112.1; ENSG00000140006.12.
DR GeneID; 112840; -.
DR KEGG; hsa:112840; -.
DR MANE-Select; ENST00000620954.2; ENSP00000480112.1; NM_080666.4; NP_542397.1.
DR UCSC; uc031qox.2; human.
DR CTD; 112840; -.
DR GeneCards; WDR89; -.
DR HGNC; HGNC:20489; WDR89.
DR HPA; ENSG00000140006; Low tissue specificity.
DR neXtProt; NX_Q96FK6; -.
DR OpenTargets; ENSG00000140006; -.
DR PharmGKB; PA134871067; -.
DR VEuPathDB; HostDB:ENSG00000140006; -.
DR eggNOG; KOG1188; Eukaryota.
DR GeneTree; ENSGT00390000006996; -.
DR HOGENOM; CLU_037323_4_0_1; -.
DR InParanoid; Q96FK6; -.
DR OMA; SDFNKYC; -.
DR OrthoDB; 1546666at2759; -.
DR PhylomeDB; Q96FK6; -.
DR TreeFam; TF324390; -.
DR PathwayCommons; Q96FK6; -.
DR SignaLink; Q96FK6; -.
DR BioGRID-ORCS; 112840; 36 hits in 1080 CRISPR screens.
DR ChiTaRS; WDR89; human.
DR GenomeRNAi; 112840; -.
DR Pharos; Q96FK6; Tdark.
DR PRO; PR:Q96FK6; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q96FK6; protein.
DR Bgee; ENSG00000140006; Expressed in kidney epithelium and 195 other tissues.
DR ExpressionAtlas; Q96FK6; baseline and differential.
DR Genevisible; Q96FK6; HS.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR039328; WDR89.
DR PANTHER; PTHR22889; PTHR22889; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..387
FT /note="WD repeat-containing protein 89"
FT /id="PRO_0000254036"
FT REPEAT 21..65
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 112..156
FT /note="WD 3"
FT REPEAT 168..208
FT /note="WD 4"
FT REPEAT 214..254
FT /note="WD 5"
FT REPEAT 319..358
FT /note="WD 6"
SQ SEQUENCE 387 AA; 43215 MW; C0F35E0066643800 CRC64;
MEKIEEQFAN LHIVKCSLGT KEPTYLLGID TSKTVQAGKE NLVAVLCSNG SIRIYDKERL
NVLREFSGYP GLLNGVRFAN SCDSVYSACT DGTVKCWDAR VAREKPVQLF KGYPSNIFIS
FDINCNDHII CAGTEKVDDD ALLVFWDARM NSQNLSTTKD SLGAYSETHS DDVTQVRFHP
SNPNMVVSGS SDGLVNVFDI NIDNEEDALV TTCNSISSVS CIGWSGKGYK QIYCMTHDEG
FYWWDLNHLD TDEPVTRLNI QDVREVVNMK EDALDYLIGG LYHEKTDTLH VIGGTNKGRI
HLMNCSMSGL THVTSLQGGH AATVRSFCWN VQDDSLLTGG EDAQLLLWKP GAIEKTFTKK
ESMKIASSVH QRVRVHSNDS YKRRKKQ
