ID   WDR89_MOUSE             Reviewed;         386 AA.
AC   Q9D0R9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=WD repeat-containing protein 89;
GN   Name=Wdr89;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK011125; BAB27418.1; -; mRNA.
DR   EMBL; BC111903; AAI11904.1; -; mRNA.
DR   EMBL; BC112430; AAI12431.1; -; mRNA.
DR   CCDS; CCDS49090.1; -.
DR   RefSeq; NP_082479.1; NM_028203.1.
DR   AlphaFoldDB; Q9D0R9; -.
DR   SMR; Q9D0R9; -.
DR   STRING; 10090.ENSMUSP00000050532; -.
DR   iPTMnet; Q9D0R9; -.
DR   PhosphoSitePlus; Q9D0R9; -.
DR   EPD; Q9D0R9; -.
DR   MaxQB; Q9D0R9; -.
DR   PaxDb; Q9D0R9; -.
DR   PeptideAtlas; Q9D0R9; -.
DR   PRIDE; Q9D0R9; -.
DR   ProteomicsDB; 299974; -.
DR   Antibodypedia; 38; 108 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000062370; ENSMUSP00000050532; ENSMUSG00000045690.
DR   Ensembl; ENSMUST00000187307; ENSMUSP00000140172; ENSMUSG00000045690.
DR   GeneID; 72338; -.
DR   KEGG; mmu:72338; -.
DR   UCSC; uc007nxj.2; mouse.
DR   CTD; 112840; -.
DR   MGI; MGI:1919588; Wdr89.
DR   VEuPathDB; HostDB:ENSMUSG00000045690; -.
DR   eggNOG; KOG1188; Eukaryota.
DR   GeneTree; ENSGT00390000006996; -.
DR   HOGENOM; CLU_037323_4_0_1; -.
DR   InParanoid; Q9D0R9; -.
DR   OMA; SDFNKYC; -.
DR   OrthoDB; 1546666at2759; -.
DR   PhylomeDB; Q9D0R9; -.
DR   TreeFam; TF324390; -.
DR   BioGRID-ORCS; 72338; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Wdr89; mouse.
DR   PRO; PR:Q9D0R9; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q9D0R9; protein.
DR   Bgee; ENSMUSG00000045690; Expressed in retinal neural layer and 149 other tissues.
DR   Genevisible; Q9D0R9; MM.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR039328; WDR89.
DR   PANTHER; PTHR22889; PTHR22889; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..386
FT                   /note="WD repeat-containing protein 89"
FT                   /id="PRO_0000330845"
FT   REPEAT          21..65
FT                   /note="WD 1"
FT   REPEAT          68..107
FT                   /note="WD 2"
FT   REPEAT          112..156
FT                   /note="WD 3"
FT   REPEAT          167..207
FT                   /note="WD 4"
FT   REPEAT          213..253
FT                   /note="WD 5"
FT   REPEAT          318..357
FT                   /note="WD 6"
SQ   SEQUENCE   386 AA;  42470 MW;  54B11349E6B29D16 CRC64;
     MEKIEDQFAS LHIVRRSSEP KEPTYLLGID TSKTVQADKG GLVAVLCSNG SIRIYDKETL
     HLLREFGGSP GLLSGVSFAN SCDSVYSAST DGTVKCWDAR GASEKPVQLF KGYPSCSFIS
     FDVNCKDHVI CAGAEKVDED ALLVFWDARF TSQDLSTRDP LGAYSETHSD DITQVRFHPS
     NPNLVVSGST DGLVNVFDLS ADKEEDALVA TCNSVSSVSC IGWCGKDYKQ IYCMTHDEGF
     CWWDLNHLDT DEPITCLNIQ DVREITDVKD GHLDYLIGGL YHEKMDRLFV IGGTNTGKIH
     LLSCTSAGLT HVTSLHGGHA ATVRSFCWNV SEDSLLTGGE DAQLLLWKPG AMEKTFTKKD
     SLKIASSVQQ RVRVHSSDSY KKRKQQ