WDR90_HUMAN
ID WDR90_HUMAN Reviewed; 1748 AA.
AC Q96KV7; Q0VA87; Q0VA88; Q6P048; Q6ZMS1; Q6ZTH1; Q8N202; Q8N221; Q8NBB8;
AC Q96PW4; Q96S18;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=WD repeat-containing protein 90;
GN Name=WDR90;
GN Synonyms=C16orf15, C16orf16, C16orf17, C16orf18, C16orf19, KIAA1924;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP THR-165 AND THR-1001.
RC TISSUE=Cerebellum, Thymus, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), AND VARIANTS
RP THR-165; LEU-250 AND ALA-537.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1138 (ISOFORM 1), AND VARIANT
RP THR-165.
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=28781053; DOI=10.1016/j.cub.2017.07.011;
RA Hamel V., Steib E., Hamelin R., Armand F., Borgers S., Flueckiger I.,
RA Busso C., Olieric N., Sorzano C.O.S., Steinmetz M.O., Guichard P.,
RA Goenczy P.;
RT "Identification of chlamydomonas central core centriolar proteins reveals a
RT role for human WDR90 in ciliogenesis.";
RL Curr. Biol. 27:2486-2498(2017).
CC -!- FUNCTION: Required for efficient primary cilium formation.
CC {ECO:0000269|PubMed:28781053}.
CC -!- INTERACTION:
CC Q96KV7; Q93062: RBPMS; NbExp=3; IntAct=EBI-9478492, EBI-740322;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000269|PubMed:28781053}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q96KV7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96KV7-10; Sequence=VSP_034290, VSP_034303, VSP_041087,
CC VSP_041088;
CC Name=3;
CC IsoId=Q96KV7-3; Sequence=VSP_034298, VSP_034300;
CC Name=4;
CC IsoId=Q96KV7-7; Sequence=VSP_034290, VSP_034303, VSP_034306;
CC Name=5;
CC IsoId=Q96KV7-5; Sequence=VSP_034294, VSP_034298, VSP_034300;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR90/POC16 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61239.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAB67817.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAC03575.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splicing.; Evidence={ECO:0000305};
CC Sequence=BAC04225.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04225.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=BAD18654.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=EAW85775.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 2]:
CC Sequence=BAC04205.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 3]:
CC Sequence=AAI21187.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 5]:
CC Sequence=AAI21186.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK091062; BAC03575.1; ALT_SEQ; mRNA.
DR EMBL; AK093609; BAC04205.1; ALT_SEQ; mRNA.
DR EMBL; AK093802; BAC04225.1; ALT_SEQ; mRNA.
DR EMBL; AK131510; BAD18654.1; ALT_SEQ; mRNA.
DR EMBL; AE006464; AAK61239.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z92544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85775.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC065836; AAH65836.1; -; mRNA.
DR EMBL; BC121185; AAI21186.1; ALT_FRAME; mRNA.
DR EMBL; BC121186; AAI21187.1; ALT_FRAME; mRNA.
DR EMBL; AB067511; BAB67817.1; ALT_SEQ; mRNA.
DR CCDS; CCDS42092.1; -. [Q96KV7-1]
DR RefSeq; NP_660337.3; NM_145294.4. [Q96KV7-1]
DR AlphaFoldDB; Q96KV7; -.
DR BioGRID; 128250; 53.
DR IntAct; Q96KV7; 28.
DR MINT; Q96KV7; -.
DR STRING; 9606.ENSP00000293879; -.
DR iPTMnet; Q96KV7; -.
DR PhosphoSitePlus; Q96KV7; -.
DR BioMuta; WDR90; -.
DR DMDM; 190423649; -.
DR jPOST; Q96KV7; -.
DR MassIVE; Q96KV7; -.
DR MaxQB; Q96KV7; -.
DR PaxDb; Q96KV7; -.
DR PeptideAtlas; Q96KV7; -.
DR PRIDE; Q96KV7; -.
DR ProteomicsDB; 77120; -. [Q96KV7-1]
DR ProteomicsDB; 77121; -. [Q96KV7-10]
DR ProteomicsDB; 77122; -. [Q96KV7-3]
DR ProteomicsDB; 77123; -. [Q96KV7-5]
DR ProteomicsDB; 77124; -. [Q96KV7-7]
DR Antibodypedia; 70705; 21 antibodies from 8 providers.
DR DNASU; 197335; -.
DR Ensembl; ENST00000293879.9; ENSP00000293879.4; ENSG00000161996.19. [Q96KV7-1]
DR Ensembl; ENST00000315764.8; ENSP00000322808.4; ENSG00000161996.19. [Q96KV7-7]
DR GeneID; 197335; -.
DR KEGG; hsa:197335; -.
DR MANE-Select; ENST00000293879.9; ENSP00000293879.4; NM_145294.5; NP_660337.3.
DR UCSC; uc002cii.2; human. [Q96KV7-1]
DR CTD; 197335; -.
DR DisGeNET; 197335; -.
DR GeneCards; WDR90; -.
DR HGNC; HGNC:26960; WDR90.
DR HPA; ENSG00000161996; Tissue enhanced (testis).
DR MIM; 618290; gene.
DR neXtProt; NX_Q96KV7; -.
DR OpenTargets; ENSG00000161996; -.
DR PharmGKB; PA145147652; -.
DR VEuPathDB; HostDB:ENSG00000161996; -.
DR eggNOG; KOG0266; Eukaryota.
DR eggNOG; KOG0318; Eukaryota.
DR eggNOG; KOG3213; Eukaryota.
DR GeneTree; ENSGT00940000160173; -.
DR HOGENOM; CLU_081013_0_0_1; -.
DR InParanoid; Q96KV7; -.
DR OrthoDB; 255317at2759; -.
DR PhylomeDB; Q96KV7; -.
DR TreeFam; TF329419; -.
DR PathwayCommons; Q96KV7; -.
DR SignaLink; Q96KV7; -.
DR BioGRID-ORCS; 197335; 16 hits in 1075 CRISPR screens.
DR ChiTaRS; WDR90; human.
DR GenomeRNAi; 197335; -.
DR Pharos; Q96KV7; Tdark.
DR PRO; PR:Q96KV7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96KV7; protein.
DR Bgee; ENSG00000161996; Expressed in right uterine tube and 145 other tissues.
DR ExpressionAtlas; Q96KV7; baseline and differential.
DR Genevisible; Q96KV7; HS.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 7.
DR InterPro; IPR007714; CFA20_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR030466; WDR90.
DR PANTHER; PTHR13720:SF24; PTHR13720:SF24; 2.
DR Pfam; PF05018; DUF667; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 20.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1748
FT /note="WD repeat-containing protein 90"
FT /id="PRO_0000341412"
FT REPEAT 407..450
FT /note="WD 1"
FT REPEAT 452..494
FT /note="WD 2"
FT REPEAT 501..541
FT /note="WD 3"
FT REPEAT 615..654
FT /note="WD 4"
FT REPEAT 656..695
FT /note="WD 5"
FT REPEAT 698..737
FT /note="WD 6"
FT REPEAT 740..779
FT /note="WD 7"
FT REPEAT 782..821
FT /note="WD 8"
FT REPEAT 882..922
FT /note="WD 9"
FT REPEAT 926..964
FT /note="WD 10"
FT REPEAT 969..1009
FT /note="WD 11"
FT REPEAT 1156..1201
FT /note="WD 12"
FT REPEAT 1204..1245
FT /note="WD 13"
FT REPEAT 1247..1286
FT /note="WD 14"
FT REPEAT 1298..1326
FT /note="WD 15"
FT REPEAT 1327..1376
FT /note="WD 16"
FT REPEAT 1433..1472
FT /note="WD 17"
FT REPEAT 1475..1520
FT /note="WD 18"
FT REPEAT 1523..1562
FT /note="WD 19"
FT REPEAT 1568..1614
FT /note="WD 20"
FT REPEAT 1715..1748
FT /note="WD 21"
FT REGION 274..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZPG2"
FT VAR_SEQ 1..1401
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_034290"
FT VAR_SEQ 280
FT /note="A -> AQ (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034294"
FT VAR_SEQ 656..708
FT /note="EHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALA
FT M -> GDAVGTLSQLPESLAWMLGRGRPSPRGSAVSRPGSWLHRVPRGQVAYPEPWGG
FT (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034298"
FT VAR_SEQ 709..1748
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034300"
FT VAR_SEQ 1402..1437
FT /note="DDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSK -> MLWFGQPGPGGW
FT NRKCLRPFTLPRGQHPQPSYGFPQ (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_034303"
FT VAR_SEQ 1580..1627
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034306"
FT VAR_SEQ 1629..1672
FT /note="TQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEK -> VNHA
FT PGTVGGAGTHPPHRSMLRLCRLRATWHPPSLPSALGMGRS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041087"
FT VAR_SEQ 1673..1748
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041088"
FT VARIANT 165
FT /note="S -> T (in dbSNP:rs13337278)"
FT /evidence="ECO:0000269|PubMed:11572484,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_044060"
FT VARIANT 250
FT /note="P -> L (in dbSNP:rs11642546)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_044061"
FT VARIANT 537
FT /note="V -> A (in dbSNP:rs3803697)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_044062"
FT VARIANT 1001
FT /note="P -> T (in dbSNP:rs4984906)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_044063"
FT VARIANT 1492
FT /note="R -> H (in dbSNP:rs7190775)"
FT /id="VAR_044064"
FT VARIANT 1555
FT /note="C -> R (in dbSNP:rs11866949)"
FT /id="VAR_044065"
FT CONFLICT 899
FT /note="H -> Q (in Ref. 1; BAD18654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1085
FT /note="P -> L (in Ref. 1; BAD18654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1245
FT /note="S -> P (in Ref. 1; BAC04225)"
FT /evidence="ECO:0000305"
FT CONFLICT 1302
FT /note="E -> G (in Ref. 1; BAC04225)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1748 AA; 187437 MW; B9FC77D5F0FAAD9D CRC64;
MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS
STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL
VLEARTPQRD LVGLAPSGAR WTCLQLDLQD VLLVYLNRCY GHLKSIRLCA SLLVRNLYTS
DLCFEPAISG AQWAKLPVTP MPREMAFPVP KGESWHDRYI HVRFPSESLK VPSKPIEKSC
SPPEAVLLGP GPQPLPCPVA SSKPVRFSVS PVVQTPSPTA SGRAALAPRP FPEVSLSQER
SDASNADGPG FHSLEPWAQL EASDIHTAAA GTHVLTHESA EVPVARTGSC EGFLPDPVLR
LKGVIGFGGH GTRQALWTPD GAAVVYPCHA VIVVLLVDTG EQRFFLGHTD KVSALALDGS
SSLLASAQAR APSVMRLWDF QTGRCLCLFR SPMHVVCSLS FSDSGALLCG VGKDHHGRTM
VVAWGTGQVG LGGEVVVLAK AHTDFDVQAF RVTFFDETRM ASCGQGSVRL WRLRGGVLRS
CPVDLGEHHA LQFTDLAFKQ ARDGCPEPSA AMLFVCSRSG HILEIDCQRM VVRHARRLLP
TRTPGGPHPQ KQTFSSGPGI AISSLSVSPA MCAVGSEDGF LRLWPLDFSS VLLEAEHEGP
VSSVCVSPDG LRVLSATSSG HLGFLDTLSR VYHMLARSHT APVLALAMEQ RRGQLATVSQ
DRTVRIWDLA TLQQLYDFTS SEDAPCAVTF HPTRPTFFCG FSSGAVRSFS LEAAEVLVEH
TCHRGAVTGL TATPDGRLLF SSCSQGSLAQ YSCADPQWHV LRVAADMVCP DAPASPSALA
VSRDGRLLAF VGPSRCTVTV MGSASLDELL RVDIGTLDLA SSRLDSAMAV CFGPAALGHL
LVSTSSNRVV VLDAVSGRII RELPGVHPEP CPSLTLSEDA RFLLIAAGRT IKVWDYATQA
SPGPQVYIGH SEPVQAVAFS PDQQQVLSAG DAVFLWDVLA PTESDQSFPG APPACKTGPG
AGPLEDAASR ASELPRQQVP KPCQASPPRL GVCARPPEGG DGARDTRNSG APRTTYLASC
KAFTPARVSC SPHSAKGTCP PPASGGWLRL KAVVGYSGNG RANMVWRPDT GFFAYTCGRL
VVVEDLHSGA QQHWSGHSAE ISTLALSHSA QVLASASGRS STTAHCQIRV WDVSGGLCQH
LIFPHSTTVL ALAFSPDDRL LVTLGDHDGR TLALWGTATY DLVSSTRLPE PVHGVAFNPW
DAGELTCVGQ GTVTFWLLQQ RGADISLQVR REPVPEAVGA GELTSLCYGA PPLLYCGTSS
GQVCVWDTRA GRCFLSWEAD DGGIGLLLFS GSRLVSGSST GRLRLWAVGA VSELRCKGSG
ASSVFMEHEL VLDGAVVSAS FDDSVDMGVV GTTAGTLWFV SWAEGTSTRL ISGHRSKVNE
VVFSPGESHC ATCSEDGSVR VWALASMELV IQFQVLNQSC LCLAWSPPCC GRPEQQRLAA
GYGDGSLRIF SVSRTAMELK MHPHPVALTT VAFSTDGQTV LSGDKDGLVA VSHPCTGTTF
RVLSDHQGAP ISTICVTCKE CEDLGVEGTD LWLAASGDQR VSVWASDWLR NHCELVDWLS
FPMPATTETQ GHLPPSLAAF CPWDGALLMY VGPGVYKEVI IYNLCQKQVV EKIPLPFFAM
SLSLSPGTHL LAVGFAECML RLVDCAMGTA QDFAGHDNAV HLCRFTPSAR LLFTAARNEI
LVWEVPGL
