WDR90_MOUSE
ID WDR90_MOUSE Reviewed; 1874 AA.
AC Q6ZPG2; Q80VI2; Q8BI97; Q8R3G7; Q921X4;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=WD repeat-containing protein 90;
GN Name=Wdr90; Synonyms=Kiaa1924;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1216-1874 (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-1874 (ISOFORM 1).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-20 AND SER-301, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for efficient primary cilium formation.
CC {ECO:0000250|UniProtKB:Q96KV7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250|UniProtKB:Q96KV7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZPG2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZPG2-2; Sequence=VSP_034309, VSP_034314;
CC Name=3;
CC IsoId=Q6ZPG2-3; Sequence=VSP_034310, VSP_034311, VSP_034312,
CC VSP_034313;
CC -!- SIMILARITY: Belongs to the WD repeat WDR90/POC16 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH25468.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK036541; BAC29467.1; -; mRNA.
DR EMBL; AC159277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043315; AAH43315.1; -; mRNA.
DR EMBL; BC009168; AAH09168.1; -; mRNA.
DR EMBL; BC025468; AAH25468.1; ALT_INIT; mRNA.
DR EMBL; AK129465; BAC98275.1; -; mRNA.
DR RefSeq; NP_001157238.1; NM_001163766.1.
DR AlphaFoldDB; Q6ZPG2; -.
DR IntAct; Q6ZPG2; 1.
DR STRING; 10090.ENSMUSP00000078426; -.
DR iPTMnet; Q6ZPG2; -.
DR PhosphoSitePlus; Q6ZPG2; -.
DR EPD; Q6ZPG2; -.
DR MaxQB; Q6ZPG2; -.
DR PaxDb; Q6ZPG2; -.
DR PRIDE; Q6ZPG2; -.
DR ProteomicsDB; 299975; -. [Q6ZPG2-1]
DR ProteomicsDB; 299976; -. [Q6ZPG2-2]
DR ProteomicsDB; 299977; -. [Q6ZPG2-3]
DR Antibodypedia; 70705; 21 antibodies from 8 providers.
DR Ensembl; ENSMUST00000176923; ENSMUSP00000135420; ENSMUSG00000073434. [Q6ZPG2-1]
DR GeneID; 106618; -.
DR KEGG; mmu:106618; -.
DR UCSC; uc008bci.2; mouse. [Q6ZPG2-1]
DR CTD; 197335; -.
DR MGI; MGI:1921267; Wdr90.
DR VEuPathDB; HostDB:ENSMUSG00000073434; -.
DR eggNOG; KOG0266; Eukaryota.
DR eggNOG; KOG0267; Eukaryota.
DR eggNOG; KOG3213; Eukaryota.
DR GeneTree; ENSGT00940000160173; -.
DR HOGENOM; CLU_002454_0_0_1; -.
DR InParanoid; Q6ZPG2; -.
DR OrthoDB; 255317at2759; -.
DR PhylomeDB; Q6ZPG2; -.
DR BioGRID-ORCS; 106618; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Wdr90; mouse.
DR PRO; PR:Q6ZPG2; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6ZPG2; protein.
DR Bgee; ENSMUSG00000073434; Expressed in islet of Langerhans and 74 other tissues.
DR ExpressionAtlas; Q6ZPG2; baseline and differential.
DR Genevisible; Q6ZPG2; MM.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 7.
DR InterPro; IPR007714; CFA20_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR030466; WDR90.
DR PANTHER; PTHR13720:SF24; PTHR13720:SF24; 2.
DR Pfam; PF05018; DUF667; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 21.
DR SUPFAM; SSF50978; SSF50978; 4.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1874
FT /note="WD repeat-containing protein 90"
FT /id="PRO_0000341413"
FT REPEAT 469..512
FT /note="WD 1"
FT REPEAT 514..556
FT /note="WD 2"
FT REPEAT 563..603
FT /note="WD 3"
FT REPEAT 677..716
FT /note="WD 4"
FT REPEAT 718..757
FT /note="WD 5"
FT REPEAT 760..799
FT /note="WD 6"
FT REPEAT 844..883
FT /note="WD 7"
FT REPEAT 944..984
FT /note="WD 8"
FT REPEAT 988..1026
FT /note="WD 9"
FT REPEAT 1031..1068
FT /note="WD 10"
FT REPEAT 1280..1325
FT /note="WD 11"
FT REPEAT 1328..1369
FT /note="WD 12"
FT REPEAT 1371..1412
FT /note="WD 13"
FT REPEAT 1422..1460
FT /note="WD 14"
FT REPEAT 1462..1500
FT /note="WD 15"
FT REPEAT 1559..1598
FT /note="WD 16"
FT REPEAT 1601..1646
FT /note="WD 17"
FT REPEAT 1649..1688
FT /note="WD 18"
FT REPEAT 1695..1740
FT /note="WD 19"
FT REPEAT 1800..1839
FT /note="WD 20"
FT REPEAT 1841..1874
FT /note="WD 21"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 20
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..1110
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034309"
FT VAR_SEQ 1..333
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034310"
FT VAR_SEQ 334..340
FT /note="QACSSAL -> MAHVPLQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034311"
FT VAR_SEQ 718..726
FT /note="EHDGPVSSV -> GEIADICLP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034312"
FT VAR_SEQ 727..1874
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034313"
FT VAR_SEQ 1111..1123
FT /note="PLSSHDRLLDGST -> MTGSLTAVLVLTV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034314"
SQ SEQUENCE 1874 AA; 202972 MW; D88DC51A74094758 CRC64;
MAGGSGARET RCRQGSRPGS PGSEVPAASV TGPRAEARPA GGGGGSRRAA PDRCSGGVPS
AAWQHPFLNV FRHFRVDEWK RSSKEGDVAV VTDKVLKSAV YRIRGSVSAS NYIQLPRTST
QSLGLTGRYL YVLFRPVPTK HFVIHLDVST EDGQVIRVSF SNLFKEFKSS TTWLQFPFVF
ETKTPRRDLA GVALPRARWT CLQLDLRDIL MFYLGRHYSH LKSIRLCASL LVRNLYTSDL
CFDPAVTVTE ARRAKLSVNP MPREMAFPVP KGESWHDNYI HVRFPSDCSK VPDEQDEKSC
SPPEAVFLGR MSRHLPHPGV LGKPLLSSKS PVAQACSSAL PCQVLSASSR LPEVSRTYRY
REVSSVSASS IQSQRPSVRD EVPDAHTVSG ERHVLADRSS GVPMALEDIG SCRLFLPDPV
LRLKGVIGFG GHSTQWALWT KDGVAVVYPC HAVIIVLQID TGQQRFFLGH TDKVSALALN
GSDTLLASAQ VQPPSMVRLW DFQTGSCLSL FRSPLHTICS LSFSGSGALL CGVGKDRHGR
TVVVAWSTEQ AGLGGEVVVL AKVHTDFDIR AFQVAFFDET RMASCGRGSV RLWRLRGGVL
RSCAVDLGEY CSLELTDLAF AQALDGHCAP SAGTLFVCSH SGHILEIDHQ RMSVQHVRRL
LPARSPGAPL AEKQNFSVGS GIAISSLSVS TATCAVGSED GYLRLWPLDF SSVLLEAEHD
GPVSSVSFSP DGLRVLSTTT SGHLGFLDVP SREYTVLARS HMAPVLALST EPNRGQMATV
SLDHTVRIWD LATLQQLYDF SSSEDTPCAV AFHPTMPNFF CGFSSGAVRS FSLESSGVLV
EHTRHRGAIT SLVITLDGRF LFSSCSQGSL VQYSCADSQC CVLRVAANMV CQDGRPNPNI
LAVSGDSCRL AFVGPSKCMV TIVESASLDE LLRVDVSTLN LASNHLDWAV AICFSPGNSG
HLLVSTSSNK VVVLDAVSGH TLRELSSVRS RACCSLALSE DAHLLLAATD RTITVWDYPT
QANPSCQVYI GHSEPVHAVA FTPDQLQVIS VGDAIFLWDI LATPERDGGD HEAPPGHEAG
SSSGQLDDLA SGASGLPRQQ VPIPFQALPP PLSSHDRLLD GSTGTFSTSD EEGLCEENHV
SEALLQGQAP TPHVLVDREA SGAGDAPRET AGSSWTPAER PSPHSHMSEW SLRSGKAGLP
TRPDSYKHFT PRYKTSPRVK SVYFPPIGRE RLRLKAIVGY NGNGRANMVW RPDTGFFAYT
CGRLVVVEDL HSGTQRHWLG HSQEISTLAL NQDGQILASA SCCGNTAARC QIRIWDVPKG
LCRHLLSHHD TAVQALAFSP DDEFLVTLGD YADRNLALWS MATYELLSST RLLEPVHGVA
FNPWDANELI CVGTNAITFW LLQHHGADTC FQVHREPIPE ELGASELTSL CYGASPLLYC
GSSSGQVCVW DTGTGHCFLA WEADDGEIGV LLCSGSRLIS GSNTKRLRLW AVGVVPELRR
KGSSARSSSV FMERELTLDG AVVSASFDSG MDMGVVGTTA GTIWYISWTE GTSTRLISGH
RTKVNEVVFS PGESHCATCG EDGSVRVWSL ASMELVIQFQ VLNQSCLCLA WTPPSCELPE
QQQVVAGYSD GTLRVFSISR TAMELKMHPH RTALTAIAFS TDGQTILSGD KDGLVAISHP
CTGMTFRVLS DHRGAPISAI QSTSKEYGDL GVEGVELWLA ASGDQRVSIW VSDWLRDRCE
LLEWLSFPAP AVSEAPGLLP PSLAAFCPWD KAILVCVGLG AHEEVIFYSL RQKQVIQKTP
LPFFAMSLSL SPGSQLMVVG FAECMMRLLD CASGTAQDLE GHDDSVHLCR FTPSGRLLFT
AAHNEILVWE VTDP
