ID   WDR90_XENTR             Reviewed;        1848 AA.
AC   A0JP70;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=WD repeat-containing protein 90;
GN   Name=wdr90;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for efficient primary cilium formation.
CC       {ECO:0000250|UniProtKB:Q96KV7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:Q96KV7}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR90/POC16 family. {ECO:0000305}.
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DR   EMBL; BC127273; AAI27274.1; -; mRNA.
DR   RefSeq; NP_001090645.1; NM_001097176.1.
DR   AlphaFoldDB; A0JP70; -.
DR   STRING; 8364.ENSXETP00000007829; -.
DR   PaxDb; A0JP70; -.
DR   DNASU; 100036617; -.
DR   GeneID; 100036617; -.
DR   KEGG; xtr:100036617; -.
DR   CTD; 197335; -.
DR   Xenbase; XB-GENE-5825492; wdr90.
DR   eggNOG; KOG0266; Eukaryota.
DR   eggNOG; KOG0267; Eukaryota.
DR   eggNOG; KOG3213; Eukaryota.
DR   InParanoid; A0JP70; -.
DR   OrthoDB; 255317at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003627; Expressed in 2-cell stage embryo and 8 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 6.
DR   InterPro; IPR007714; CFA20_dom.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR030466; WDR90.
DR   PANTHER; PTHR13720:SF24; PTHR13720:SF24; 2.
DR   Pfam; PF05018; DUF667; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 21.
DR   SUPFAM; SSF50978; SSF50978; 4.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..1848
FT                   /note="WD repeat-containing protein 90"
FT                   /id="PRO_0000341414"
FT   REPEAT          436..479
FT                   /note="WD 1"
FT   REPEAT          481..523
FT                   /note="WD 2"
FT   REPEAT          530..570
FT                   /note="WD 3"
FT   REPEAT          644..683
FT                   /note="WD 4"
FT   REPEAT          685..724
FT                   /note="WD 5"
FT   REPEAT          727..766
FT                   /note="WD 6"
FT   REPEAT          769..808
FT                   /note="WD 7"
FT   REPEAT          811..850
FT                   /note="WD 8"
FT   REPEAT          955..993
FT                   /note="WD 9"
FT   REPEAT          998..1035
FT                   /note="WD 10"
FT   REPEAT          1252..1297
FT                   /note="WD 11"
FT   REPEAT          1300..1341
FT                   /note="WD 12"
FT   REPEAT          1343..1382
FT                   /note="WD 13"
FT   REPEAT          1395..1433
FT                   /note="WD 14"
FT   REPEAT          1435..1473
FT                   /note="WD 15"
FT   REPEAT          1532..1571
FT                   /note="WD 16"
FT   REPEAT          1574..1621
FT                   /note="WD 17"
FT   REPEAT          1624..1663
FT                   /note="WD 18"
FT   REPEAT          1670..1714
FT                   /note="WD 19"
FT   REPEAT          1774..1813
FT                   /note="WD 20"
FT   REPEAT          1815..1848
FT                   /note="WD 21"
FT   REGION          257..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1053..1133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1151..1178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..336
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1113..1131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1151..1165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1848 AA;  203426 MW;  FCC2529BE88F62FC CRC64;
     MAGVWQHPFV NVFKHLRLEE WKKSSKEGDV TSVMDKTLKC TVYRIRGSIP AGNYIQLPKT
     SSQSLGLTGR YLYILFKPLP GKHFVVHIDV SAEDGQTVRI SFSNLFKEFK STATWLQFPF
     VCGAIKGSVY DSTAQGARQG MVGPAPSGSR WTCLLLDVQY ILSLYLSRRY SHLRSAKLCS
     NLLVRNLMTS DLLFNPEVNF MEARHAKTLP DGISPMPREM SFPVPKGEKW HDLYDFIMFP
     SDSSKLPYDS IQKGQSMVTA PGAPMSRSPA RERPRSVTIS KPVQDRVSLI QQITTPRPMP
     HRSLLRVESV PERPVSVSAR AEEARDLEDR SRGVEQDGGV HVYAHKTNKL SIHRHKSDSE
     QVICTKVDRP ETLSVPPECK KLLPDPIFNL RRIIGFGGCT ECFALWTHTG CSVVYPCHAI
     IVVLEVKTGE QRFLLGHTDK VSALAFNGSC TLLASAQTGS LSMVRLWHFQ KGSCLAMFKT
     HVHSVSYLSF SHSGTVLCGV GKDGHGKTMV VVWNTSQASR SGEVAVLAKA HTDIDIQTMK
     IAFFDDTRMV SCGKDNVRLW RVRGGTLRSC PVNLGEYHML EFSDLAFEAG HRPEKEAEDR
     TLYVSSRSGH ILEIDYKNVV LRNVRRVQPG QQQHSERRDK QTFSSGPGIA INSLSVSATF
     CATGTEDGYL RLWPLDFSGV FLEAEHEGPV SCVAISPEGL RVLSCTSSGE LGVLDVPSRG
     YNTLMRSHTD TLLSFSCHPT HPQLVTVSSD NTIRIWDTGT LQQLYDFTAE EETPCAVTFH
     PVRQAFACGF SSGTIRFFDI TATALQAEHK QHRGAITGLL FSPDGSLMYS CCSLGSVALY
     SIGHKEQHVL RVLGNVVCKD SERGPMALSL SSDGRLLAFV GPTEYTVTVM DARSLDELLR
     VDVSILDLDS TTLDCALGLA FSPLKPHHLL VSTSGNKILW LDPKTGRLTR EVTQVHKQCC
     SSLAVSMDTR YMLTAGDRLL KVWDQRQPGT VRPQVFIGHS EAVQQVDFSP DQQSVISAGD
     AVFIWDFLAA PDPEFTKTDC VPALPFALHS SAALDPSSEH RRDSTFISSG MPRGTAPRPC
     ISSPPRLDIS PVQGMDHPDL FSESDDGQEE EGNRDEQERT LVPDTRDNLV ESDEQSSVVI
     IECQPNRAKL LTGSKSNSSS LREGMVKSTH EPPRPDSYTH FHTRFKASCL AKGMCHPPEG
     QEMLTLRALI GYNGNGRANM AWNPDTGFFS YTCGCVIVVE DLHSGSQRHW LGHPEEISTL
     ALTNDALVLA SASGSGDGSS LCQIRIWDTQ DGSCMKILTH HRTEVQAMSY SRDDRLFVSI
     GDYRDGNLAL WSTKGYELLA TSRLFQPVHA VTFNPAHFDD FASAGPGAVS FWRIETQGTD
     TQIKVYRVAV PEEVGTAAEL TSITYNSTSL LYSGCSTGQV CVWDCQTHRC FLTWEADQGE
     IGILLCRGNR LLTGSNTRRI RLWCVAAVQE LREKGSGASS TSVLMEHEMT LDGAIVSATF
     DDALEMGIVG TTAGTLWYIN WVENTSIRLI SGHRNKVMDL AVAHGESHCA TCGEDGSLRI
     WSLQSCELLL QFQVLNQSCL CLAWSPQPKS GPSTEDQRIA AGYSDGTIRI FSVSKTEMEM
     KIHPHPCAVT SIAYSTSGDV LLTGGKDGQM AITSPRTGMT IRVLSDHKGS PITTIECTGR
     KLTGLPTDGE LWLAASTDRR VSIWASDWSK DKCELLDWLS FPAPTSQKDL DVSVPTLAAF
     CPWQPGTVVY SGFGVEKEIL FYSLIQKQVL LRIPLSHFAT SLTLSPAASL IAVGSNERLL
     RLIDTSAGTK QDFAAYDDGV HLCRVSPSGN LLLTASYNQV LVWDIQNS