WDR91_DICDI
ID WDR91_DICDI Reviewed; 766 AA.
AC Q55FJ2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=WD repeat-containing protein 91 homolog {ECO:0000305};
GN Name=wdr91 {ECO:0000312|dictyBase:DDB_G0268084};
GN ORFNames=DDB_G0268084 {ECO:0000312|dictyBase:DDB_G0268084};
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K
CC activity associated with endosomal membranes. By modifying the
CC phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal
CC membranes may regulate endosome fusion, recycling, sorting and early to
CC late endosome transport. {ECO:0000250|UniProtKB:A4D1P6}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000250|UniProtKB:A4D1P6}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:A4D1P6}. Late endosome membrane
CC {ECO:0000250|UniProtKB:A4D1P6}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73495.1; -; Genomic_DNA.
DR RefSeq; XP_647541.1; XM_642449.1.
DR AlphaFoldDB; Q55FJ2; -.
DR SMR; Q55FJ2; -.
DR STRING; 44689.DDB0233074; -.
DR PaxDb; Q55FJ2; -.
DR EnsemblProtists; EAL73495; EAL73495; DDB_G0268084.
DR GeneID; 8616348; -.
DR KEGG; ddi:DDB_G0268084; -.
DR dictyBase; DDB_G0268084; wdr91.
DR eggNOG; KOG1333; Eukaryota.
DR HOGENOM; CLU_022078_0_0_1; -.
DR InParanoid; Q55FJ2; -.
DR OMA; VLFQCML; -.
DR PhylomeDB; Q55FJ2; -.
DR PRO; PR:Q55FJ2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0031313; C:extrinsic component of endosome membrane; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR GO; GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; PTHR13083; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Endosome; Membrane; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..766
FT /note="WD repeat-containing protein 91 homolog"
FT /id="PRO_0000327477"
FT REPEAT 462..501
FT /note="WD 1"
FT REPEAT 503..542
FT /note="WD 2"
FT REPEAT 547..591
FT /note="WD 3"
FT REPEAT 594..633
FT /note="WD 4"
FT REPEAT 636..675
FT /note="WD 5"
FT REPEAT 684..723
FT /note="WD 6"
FT REPEAT 726..766
FT /note="WD 7"
FT REGION 88..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 86258 MW; FD92BAA5F5AB7294 CRC64;
MNSSNLNYLD ELVKEYLIFR GFTQTNHYFS LEKKGDKLKG FQVDRILEQI NIYISSYDIN
HLVELWNFLD ITFFSKIDYN KSNAYNNNNN NNNNYNSNHN SNGSYTSYRN NNNDLQSTIK
KLSSSLRKYY VIYAINNNKI DKVKEFFDQY SLELLKDPDW QSWFALPYIR NPQSDPLFEI
YFSKTWSEAF SLSLRNFLST IFKNIPLPKI LQFNLERQNR KRLETQVENL LSINEELRSQ
VDKLEYQNKR DQNNSGSNNN SNNNSNSGFT IGNVSQRKES NVNNFNSGND LNSSNEREVN
SFSRVSKRFE PRSTSSTNIA AMDDDDNKPM IGIGRSRKSI STNSVNSNNN INNNNTSNTN
TNTNTNTNTN TNSNSNTNTN TNSNSNTNTS NNNSNSNNNN NGTNTNVTNN NGFQHLNLSG
FEMTEIDENG FKKKSSNGLN GSDGIENGEL VYNIESQEVC TSHSSAITRC KFLSNGSKIA
SSSIDGTVRL WNVGFSSRQT TIYCLSEVAS LEWENRSKLL LCGTIDSKIK IWNSLTDKAI
GDINTSIEFP RVEDIACNPN GNSFATSSIN NGRTDGVVYT WNLRTLKTEE KLSSSGAVIN
SMSFNSTGTL LSTGCVDGTI RIFDIKSGSP IAGWQAHSNE ILSVQFSSDE NRLYSLGKDG
KLYQWNIHSM GKPVKEYDYP GFLVDPHRTT KISFNHNQSS FLVGTNNKFA LLYNIDQSSP
ILQISGHTGP VVTCDWNSSS QSDVIITGSL DKTIRLTKLS KSFNNL
