WDR91_HUMAN
ID WDR91_HUMAN Reviewed; 747 AA.
AC A4D1P6; A6NK54; C9JMI4; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062;
AC Q9H9B6; Q9NVG7; Q9NZY6;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000312|HGNC:HGNC:24997};
GN Name=WDR91 {ECO:0000312|HGNC:HGNC:24997};
GN ORFNames=HSPC049 {ECO:0000312|EMBL:AAF29021.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-257.
RC TISSUE=Blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT LEU-257.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-257.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-257.
RC TISSUE=Brain, Colon, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-747 (ISOFORM 1), AND VARIANT
RP LEU-257.
RC TISSUE=Uterus;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-747 (ISOFORM 1), AND VARIANT
RP LEU-257.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP FUNCTION, INTERACTION WITH BECN1 AND WDR81, SUBCELLULAR LOCATION, AND
RP TOPOLOGY.
RX PubMed=26783301; DOI=10.1083/jcb.201506081;
RA Liu K., Jian Y., Sun X., Yang C., Gao Z., Zhang Z., Liu X., Li Y., Xu J.,
RA Jing Y., Mitani S., He S., Yang C.;
RT "Negative regulation of phosphatidylinositol 3-phosphate levels in early-
RT to-late endosome conversion.";
RL J. Cell Biol. 212:181-198(2016).
RN [13]
RP FUNCTION, AND INTERACTION WITH WDR81.
RX PubMed=27126989; DOI=10.1111/tra.12409;
RA Rapiteanu R., Davis L.J., Williamson J.C., Timms R.T., Paul Luzio J.,
RA Lehner P.J.;
RT "A genetic screen identifies a critical role for the WDR81-WDR91 complex in
RT the trafficking and degradation of tetherin.";
RL Traffic 17:940-958(2016).
RN [14]
RP SUBCELLULAR LOCATION.
RX PubMed=28404643; DOI=10.1083/jcb.201608039;
RA Liu X., Li Y., Wang X., Xing R., Liu K., Gan Q., Tang C., Gao Z., Jian Y.,
RA Luo S., Guo W., Yang C.;
RT "The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote
RT aggrephagy.";
RL J. Cell Biol. 216:1301-1320(2017).
CC -!- FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K
CC activity associated with endosomal membranes via BECN1, a core subunit
CC of the PI3K complex. By modifying the phosphatidylinositol 3-
CC phosphate/PtdInsP3 content of endosomal membranes may regulate endosome
CC fusion, recycling, sorting and early to late endosome transport
CC (PubMed:26783301). It is for instance, required for the delivery of
CC cargos like BST2/tetherin from early to late endosome and thereby
CC participates indirectly to their degradation by the lysosome
CC (PubMed:27126989). May play a role in meiosis (By similarity).
CC {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301,
CC ECO:0000269|PubMed:27126989}.
CC -!- SUBUNIT: Interacts with WDR81; involved in early to late endosome cargo
CC transport (PubMed:26783301, PubMed:27126989). Interacts with BECN1;
CC negatively regulates the PI3 kinase/PI3K activity associated with
CC endosomal membranes (PubMed:26783301). {ECO:0000269|PubMed:26783301,
CC ECO:0000269|PubMed:27126989}.
CC -!- INTERACTION:
CC A4D1P6; P42858: HTT; NbExp=16; IntAct=EBI-718046, EBI-466029;
CC A4D1P6; Q562E7: WDR81; NbExp=3; IntAct=EBI-718046, EBI-5235360;
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000269|PubMed:26783301}; Peripheral membrane protein
CC {ECO:0000269|PubMed:26783301}. Late endosome membrane
CC {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28404643}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A4D1P6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4D1P6-2; Sequence=VSP_027060, VSP_027061;
CC Name=3;
CC IsoId=A4D1P6-3; Sequence=VSP_027058, VSP_027059;
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF29021.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF161534; AAF29021.1; ALT_FRAME; mRNA.
DR EMBL; AK001606; BAA91785.1; -; mRNA.
DR EMBL; AK022935; BAB14316.1; -; mRNA.
DR EMBL; BX640957; CAE45977.1; -; mRNA.
DR EMBL; AC009542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC083862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24062.1; -; Genomic_DNA.
DR EMBL; BC009939; AAH09939.2; -; mRNA.
DR EMBL; BC017246; AAH17246.1; -; mRNA.
DR EMBL; BC063394; AAH63394.1; -; mRNA.
DR EMBL; AL136940; CAB66874.2; -; mRNA.
DR EMBL; CR533561; CAG38592.1; -; mRNA.
DR CCDS; CCDS34758.1; -. [A4D1P6-1]
DR RefSeq; NP_054868.3; NM_014149.3. [A4D1P6-1]
DR PDB; 6VYC; X-ray; 2.10 A; A/B=392-747.
DR PDBsum; 6VYC; -.
DR AlphaFoldDB; A4D1P6; -.
DR SMR; A4D1P6; -.
DR BioGRID; 118837; 27.
DR IntAct; A4D1P6; 13.
DR STRING; 9606.ENSP00000346466; -.
DR iPTMnet; A4D1P6; -.
DR PhosphoSitePlus; A4D1P6; -.
DR BioMuta; WDR91; -.
DR EPD; A4D1P6; -.
DR jPOST; A4D1P6; -.
DR MassIVE; A4D1P6; -.
DR MaxQB; A4D1P6; -.
DR PaxDb; A4D1P6; -.
DR PeptideAtlas; A4D1P6; -.
DR PRIDE; A4D1P6; -.
DR ProteomicsDB; 624; -. [A4D1P6-1]
DR ProteomicsDB; 625; -. [A4D1P6-2]
DR ProteomicsDB; 626; -. [A4D1P6-3]
DR Antibodypedia; 18119; 98 antibodies from 15 providers.
DR DNASU; 29062; -.
DR Ensembl; ENST00000354475.5; ENSP00000346466.4; ENSG00000105875.15. [A4D1P6-1]
DR Ensembl; ENST00000684339.1; ENSP00000508261.1; ENSG00000105875.15. [A4D1P6-2]
DR GeneID; 29062; -.
DR KEGG; hsa:29062; -.
DR MANE-Select; ENST00000354475.5; ENSP00000346466.4; NM_014149.4; NP_054868.3.
DR UCSC; uc003vsp.3; human. [A4D1P6-1]
DR CTD; 29062; -.
DR GeneCards; WDR91; -.
DR HGNC; HGNC:24997; WDR91.
DR HPA; ENSG00000105875; Low tissue specificity.
DR neXtProt; NX_A4D1P6; -.
DR OpenTargets; ENSG00000105875; -.
DR PharmGKB; PA162409166; -.
DR VEuPathDB; HostDB:ENSG00000105875; -.
DR eggNOG; KOG1333; Eukaryota.
DR GeneTree; ENSGT00390000001566; -.
DR HOGENOM; CLU_022078_0_0_1; -.
DR InParanoid; A4D1P6; -.
DR OMA; VLFQCML; -.
DR OrthoDB; 321271at2759; -.
DR PhylomeDB; A4D1P6; -.
DR TreeFam; TF317339; -.
DR PathwayCommons; A4D1P6; -.
DR Reactome; R-HSA-9013148; CDC42 GTPase cycle.
DR SignaLink; A4D1P6; -.
DR BioGRID-ORCS; 29062; 34 hits in 1092 CRISPR screens.
DR ChiTaRS; WDR91; human.
DR GenomeRNAi; 29062; -.
DR Pharos; A4D1P6; Tbio.
DR PRO; PR:A4D1P6; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A4D1P6; protein.
DR Bgee; ENSG00000105875; Expressed in right uterine tube and 160 other tissues.
DR ExpressionAtlas; A4D1P6; baseline and differential.
DR Genevisible; A4D1P6; HS.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IDA:UniProtKB.
DR GO; GO:0031313; C:extrinsic component of endosome membrane; IDA:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IDA:UniProtKB.
DR GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IMP:UniProtKB.
DR GO; GO:0045022; P:early endosome to late endosome transport; IMP:UniProtKB.
DR GO; GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB.
DR GO; GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; PTHR13083; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Endosome; Membrane;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..747
FT /note="WD repeat-containing protein 91"
FT /id="PRO_0000295746"
FT REPEAT 406..445
FT /note="WD 1"
FT REPEAT 448..488
FT /note="WD 2"
FT REPEAT 515..555
FT /note="WD 3"
FT REPEAT 560..599
FT /note="WD 4"
FT REPEAT 602..641
FT /note="WD 5"
FT REPEAT 664..702
FT /note="WD 6"
FT REPEAT 709..747
FT /note="WD 7"
FT REGION 265..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 183..215
FT /evidence="ECO:0000255"
FT COMPBIAS 265..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16964243"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMQ7"
FT VAR_SEQ 351..365
FT /note="CAEKKPEASGPEAEP -> VWGCPEHPWGHSCSY (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027058"
FT VAR_SEQ 366..747
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027059"
FT VAR_SEQ 590..636
FT /note="DMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKS -> V
FT HPVEHPQEWPQGIRVQPPLRCHGPLCAVWIQRLQAGSSPQGPTLRF (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027060"
FT VAR_SEQ 637..747
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027061"
FT VARIANT 257
FT /note="P -> L (in dbSNP:rs292592)"
FT /evidence="ECO:0000269|PubMed:11042152,
FT ECO:0000269|PubMed:11230166, ECO:0000269|PubMed:12690205,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.8"
FT /id="VAR_033358"
FT CONFLICT 302
FT /note="K -> R (in Ref. 2; BAA91785)"
FT /evidence="ECO:0000305"
FT CONFLICT 449
FT /note="S -> F (in Ref. 1; AAF29021)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="F -> L (in Ref. 1; AAF29021)"
FT /evidence="ECO:0000305"
FT CONFLICT 706
FT /note="S -> K (in Ref. 1; AAF29021)"
FT /evidence="ECO:0000305"
FT STRAND 396..404
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 411..416
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 420..427
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 431..436
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 438..440
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 442..448
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 453..458
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 460..462
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 465..479
FT /evidence="ECO:0007829|PDB:6VYC"
FT TURN 480..483
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 484..490
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 493..495
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 497..503
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 507..515
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 540..546
FT /evidence="ECO:0007829|PDB:6VYC"
FT TURN 547..550
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 551..555
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 559..561
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 565..570
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 572..581
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 584..590
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 597..601
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 607..612
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 616..623
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 627..632
FT /evidence="ECO:0007829|PDB:6VYC"
FT TURN 633..637
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 639..644
FT /evidence="ECO:0007829|PDB:6VYC"
FT HELIX 647..649
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 653..656
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 662..665
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 671..674
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 678..683
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 690..693
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 703..706
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 714..724
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 726..732
FT /evidence="ECO:0007829|PDB:6VYC"
FT STRAND 737..744
FT /evidence="ECO:0007829|PDB:6VYC"
SQ SEQUENCE 747 AA; 83344 MW; A93CF7F02D12629A CRC64;
MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ QLMQVYDLAA
LRDYWSYLER RLFSRLEDIY RPTIHKLKTS LFRFYLVYTI QTNRNDKAQE FFAKQATELQ
NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ WADTFIVSLH NFLSVLFQCM PVPVILNFDA
ECQRTNQVQE ENEVLRQKLF ALQAEIHRLK KEEQQPEEEE ALVQHKLPPY VSNMDRLGDS
ELAMVCSQRN ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQPQSSAK KESFGGQGTK
GKDPTSGAKD GKSLLSGLAT GESGWSQHRQ RRLQDHGKER KELFSTTTSQ CAEKKPEASG
PEAEPCPELH TEPVEPLTRA SSAGPEGGGV RPEQPFIVLG QEEYGEHHSS IMHCRVDCSG
RRVASLDVDG VIKVWSFNPI MQTKASSISK SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT
EAKKNLCEIN INDNMPRILS LACSPNGASF VCSAAAPSLT SQVDFSAPDI GSKGMNQVPG
RLLLWDTKTM KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHECAMSW
RAHYGEVYSV EFSYDENTVY SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT GPFVLSGYSG
YKQVQVPRGR LFAFDSEGNY MLTCSATGGV IYKLGGDEKV LESCLSLGGH RAPVVTVDWS
TAMDCGTCLT ASMDGKIKLT TLLAHKA
