WDR91_RAT
ID WDR91_RAT Reviewed; 747 AA.
AC B2RYI0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000312|RGD:1306697};
GN Name=Wdr91 {ECO:0000312|RGD:1306697};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K
CC activity associated with endosomal membranes via BECN1, a core subunit
CC of the PI3K complex. By modifying the phosphatidylinositol 3-
CC phosphate/PtdInsP3 content of endosomal membranes may regulate endosome
CC fusion, recycling, sorting and early to late endosome transport. It is
CC for instance, required for the delivery of cargos like BST2/tetherin
CC from early to late endosome and thereby participates indirectly to
CC their degradation by the lysosome. May play a role in meiosis.
CC {ECO:0000250|UniProtKB:A4D1P6, ECO:0000250|UniProtKB:Q7TMQ7}.
CC -!- SUBUNIT: Interacts with WDR81; involved in early to late endosome cargo
CC transport. Interacts with BECN1; negatively regulates the PI3
CC kinase/PI3K activity associated with endosomal membranes.
CC {ECO:0000250|UniProtKB:A4D1P6}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000250|UniProtKB:A4D1P6}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:A4D1P6}. Late endosome membrane
CC {ECO:0000250|UniProtKB:A4D1P6}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family. {ECO:0000305}.
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DR EMBL; BC166785; AAI66785.1; -; mRNA.
DR RefSeq; NP_001120770.2; NM_001127298.2.
DR AlphaFoldDB; B2RYI0; -.
DR SMR; B2RYI0; -.
DR IntAct; B2RYI0; 4.
DR STRING; 10116.ENSRNOP00000014010; -.
DR iPTMnet; B2RYI0; -.
DR PhosphoSitePlus; B2RYI0; -.
DR jPOST; B2RYI0; -.
DR PaxDb; B2RYI0; -.
DR PeptideAtlas; B2RYI0; -.
DR PRIDE; B2RYI0; -.
DR Ensembl; ENSRNOT00000014010; ENSRNOP00000014010; ENSRNOG00000010421.
DR GeneID; 312225; -.
DR KEGG; rno:312225; -.
DR UCSC; RGD:1306697; rat.
DR CTD; 29062; -.
DR RGD; 1306697; Wdr91.
DR eggNOG; KOG1333; Eukaryota.
DR GeneTree; ENSGT00390000001566; -.
DR HOGENOM; CLU_022078_0_0_1; -.
DR InParanoid; B2RYI0; -.
DR OMA; VLFQCML; -.
DR OrthoDB; 321271at2759; -.
DR PhylomeDB; B2RYI0; -.
DR TreeFam; TF317339; -.
DR Reactome; R-RNO-9013148; CDC42 GTPase cycle.
DR PRO; PR:B2RYI0; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000010421; Expressed in spleen and 19 other tissues.
DR Genevisible; B2RYI0; RN.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0031313; C:extrinsic component of endosome membrane; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR GO; GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; PTHR13083; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Endosome; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..747
FT /note="WD repeat-containing protein 91"
FT /id="PRO_0000366949"
FT REPEAT 406..445
FT /note="WD 1"
FT REPEAT 448..488
FT /note="WD 2"
FT REPEAT 511..555
FT /note="WD 3"
FT REPEAT 560..599
FT /note="WD 4"
FT REPEAT 602..641
FT /note="WD 5"
FT REPEAT 664..702
FT /note="WD 6"
FT REPEAT 709..747
FT /note="WD 7"
FT REGION 265..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 183..227
FT /evidence="ECO:0000255"
FT COMPBIAS 265..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A4D1P6"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A4D1P6"
SQ SEQUENCE 747 AA; 83146 MW; 9442DEF0AF22AD17 CRC64;
MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ QLMQVYDLAA
LRDYWSYLER RLFSRLEDIY RPTINKLKTS LFRFYLVYTI QTNRNDKAQE FFAKQATELQ
NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ WADTFIISLH NFLSVLFQCM PVPVILNFDA
ECQRTNQVQE ENEVLRQKLF ALQAEVHRLK KEEQQQEEAA ALVQHKLPPY VSSMDRLGDS
ELALVCSQRP ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQAQSSAK KDTFSSQATK
GKDPVPGAKD GKSLLSGPVP GEASWTHQRQ RRLQDHGKER RELLSTSSSQ TQCAEKKLEG
SGPEAELCLD LHMGPVEALA RVSTAGSEGD RPEQPFIVLS QEEYGEHHSS IMHCRVDCSG
RRVASLDVDG VIKVWSFNPI MQTKASSISK SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT
EAKKNLCEIN INDDMPRILS LACSPNGASF VCSAAAPSLT SQPDSSAPDI GSKGMNQVPG
KLLLWDTKTM KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHGCAMSW
KAHCGEVYSV EFSYDENAVN SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT GPFVLSGYSG
YKQVQVPRGR LFAFDSEGNY MLTCSATGGL IYKLGSEEKV LENCLSLGGH RAPVVTVDWS
TAMDCGTCLT ASMDGKIKLT TLLAHKL
