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WDR91_XENTR
ID   WDR91_XENTR             Reviewed;         751 AA.
AC   Q05B30;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=WD repeat-containing protein 91 {ECO:0000250|UniProtKB:A4D1P6};
GN   Name=wdr91 {ECO:0000250|UniProtKB:A4D1P6};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K
CC       activity associated with endosomal membranes. By modifying the
CC       phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal
CC       membranes may regulate endosome fusion, recycling, sorting and early to
CC       late endosome transport. {ECO:0000250|UniProtKB:A4D1P6}.
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane
CC       {ECO:0000250|UniProtKB:A4D1P6}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:A4D1P6}. Late endosome membrane
CC       {ECO:0000250|UniProtKB:A4D1P6}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR91 family. {ECO:0000305}.
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DR   EMBL; BC122936; AAI22937.1; -; mRNA.
DR   RefSeq; NP_001072579.1; NM_001079111.1.
DR   AlphaFoldDB; Q05B30; -.
DR   SMR; Q05B30; -.
DR   STRING; 8364.ENSXETP00000057530; -.
DR   PaxDb; Q05B30; -.
DR   DNASU; 780034; -.
DR   GeneID; 780034; -.
DR   KEGG; xtr:780034; -.
DR   CTD; 29062; -.
DR   Xenbase; XB-GENE-969792; wdr91.
DR   eggNOG; KOG1333; Eukaryota.
DR   InParanoid; Q05B30; -.
DR   OrthoDB; 321271at2759; -.
DR   Reactome; R-XTR-9013148; CDC42 GTPase cycle.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020237; Expressed in blastula and 13 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0031313; C:extrinsic component of endosome membrane; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR039724; WDR91.
DR   PANTHER; PTHR13083; PTHR13083; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..751
FT                   /note="WD repeat-containing protein 91"
FT                   /id="PRO_0000295751"
FT   REPEAT          410..449
FT                   /note="WD 1"
FT   REPEAT          452..492
FT                   /note="WD 2"
FT   REPEAT          517..559
FT                   /note="WD 3"
FT   REPEAT          564..603
FT                   /note="WD 4"
FT   REPEAT          606..645
FT                   /note="WD 5"
FT   REPEAT          668..706
FT                   /note="WD 6"
FT   REPEAT          713..751
FT                   /note="WD 7"
FT   REGION          237..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          183..205
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        237..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   751 AA;  83760 MW;  2B3C7ADF881DD0E4 CRC64;
     MTSAVELTDD LVKEYLTFRG FTNTLKYFEV DIKADKDKGF RVDRIVEQLL QFVQSYDLNG
     LVEYWAYLER RLFSRLEDVY RPTIHKLKTS LFRYYLVYTI QSSRTDKAHE FFQKQATELQ
     NQAEWKEWFA LPFLPTPDSN RTFSTYFSRQ WADTFTVSLH NFLSVLFQCM PVPKILTFQS
     DYQKIACLQE ENEIMRQKLF ALQAETYRLR KDGPSEPLVL HKLPHYVSNM DRLGDSELGS
     NIMSSHSNTN MNTPSQRTSG FLSSLLAQNK KPPPPKSTLP SVSSPTQSGG SVPLKKEVAV
     SQAQKAKELV GGTKEVRSSP NILGVPGTES SMVQQRHKRQ QERKELLSKT ASQVSTEKKA
     ENSDADPDLR SDTQNDTVDA VTRGSGASGA RKEEKPAQPF IVLSQDEYAE HHSSIMHCRV
     DCSGRRVASL DVDGVIKIWS LDGIMQTKAS AISKSALLSL EWATKRDRLL LLGSEVGTVR
     LYDTEAKKNL CEIGIVEDMP RILSLACSPS GASFVCSAAA ATSPSQTDPT YYSYGESGNN
     QVPGKLLLWD TKTMKQQLQF SLEPVPIAVN CTAFNHNGNL LVTGAADGFI RLFDMQQHQC
     ALSWKAHMGE VYSVDFSYDE NAVYSIGEDG KFIQWDIHKS GQKVSEYSLP SDATGPFMLS
     GYSGYKQVQF PRGRLFAFDS EGKYMLTCSS TGGVIYKLNS DGSTLENCLS LGGHRAPVVT
     VDWSTAVECG TCLTASMDGK IKLTTLLAQK S
 
 
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