WDR91_XENTR
ID WDR91_XENTR Reviewed; 751 AA.
AC Q05B30;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000250|UniProtKB:A4D1P6};
GN Name=wdr91 {ECO:0000250|UniProtKB:A4D1P6};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K
CC activity associated with endosomal membranes. By modifying the
CC phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal
CC membranes may regulate endosome fusion, recycling, sorting and early to
CC late endosome transport. {ECO:0000250|UniProtKB:A4D1P6}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000250|UniProtKB:A4D1P6}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:A4D1P6}. Late endosome membrane
CC {ECO:0000250|UniProtKB:A4D1P6}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family. {ECO:0000305}.
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DR EMBL; BC122936; AAI22937.1; -; mRNA.
DR RefSeq; NP_001072579.1; NM_001079111.1.
DR AlphaFoldDB; Q05B30; -.
DR SMR; Q05B30; -.
DR STRING; 8364.ENSXETP00000057530; -.
DR PaxDb; Q05B30; -.
DR DNASU; 780034; -.
DR GeneID; 780034; -.
DR KEGG; xtr:780034; -.
DR CTD; 29062; -.
DR Xenbase; XB-GENE-969792; wdr91.
DR eggNOG; KOG1333; Eukaryota.
DR InParanoid; Q05B30; -.
DR OrthoDB; 321271at2759; -.
DR Reactome; R-XTR-9013148; CDC42 GTPase cycle.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000020237; Expressed in blastula and 13 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0031313; C:extrinsic component of endosome membrane; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR GO; GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; PTHR13083; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Endosome; Membrane; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..751
FT /note="WD repeat-containing protein 91"
FT /id="PRO_0000295751"
FT REPEAT 410..449
FT /note="WD 1"
FT REPEAT 452..492
FT /note="WD 2"
FT REPEAT 517..559
FT /note="WD 3"
FT REPEAT 564..603
FT /note="WD 4"
FT REPEAT 606..645
FT /note="WD 5"
FT REPEAT 668..706
FT /note="WD 6"
FT REPEAT 713..751
FT /note="WD 7"
FT REGION 237..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 183..205
FT /evidence="ECO:0000255"
FT COMPBIAS 237..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 83760 MW; 2B3C7ADF881DD0E4 CRC64;
MTSAVELTDD LVKEYLTFRG FTNTLKYFEV DIKADKDKGF RVDRIVEQLL QFVQSYDLNG
LVEYWAYLER RLFSRLEDVY RPTIHKLKTS LFRYYLVYTI QSSRTDKAHE FFQKQATELQ
NQAEWKEWFA LPFLPTPDSN RTFSTYFSRQ WADTFTVSLH NFLSVLFQCM PVPKILTFQS
DYQKIACLQE ENEIMRQKLF ALQAETYRLR KDGPSEPLVL HKLPHYVSNM DRLGDSELGS
NIMSSHSNTN MNTPSQRTSG FLSSLLAQNK KPPPPKSTLP SVSSPTQSGG SVPLKKEVAV
SQAQKAKELV GGTKEVRSSP NILGVPGTES SMVQQRHKRQ QERKELLSKT ASQVSTEKKA
ENSDADPDLR SDTQNDTVDA VTRGSGASGA RKEEKPAQPF IVLSQDEYAE HHSSIMHCRV
DCSGRRVASL DVDGVIKIWS LDGIMQTKAS AISKSALLSL EWATKRDRLL LLGSEVGTVR
LYDTEAKKNL CEIGIVEDMP RILSLACSPS GASFVCSAAA ATSPSQTDPT YYSYGESGNN
QVPGKLLLWD TKTMKQQLQF SLEPVPIAVN CTAFNHNGNL LVTGAADGFI RLFDMQQHQC
ALSWKAHMGE VYSVDFSYDE NAVYSIGEDG KFIQWDIHKS GQKVSEYSLP SDATGPFMLS
GYSGYKQVQF PRGRLFAFDS EGKYMLTCSS TGGVIYKLNS DGSTLENCLS LGGHRAPVVT
VDWSTAVECG TCLTASMDGK IKLTTLLAQK S