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WDR93_HUMAN
ID   WDR93_HUMAN             Reviewed;         686 AA.
AC   Q6P2C0; Q8N7Y8; Q9NP89;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=WD repeat-containing protein 93;
GN   Name=WDR93;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 306-686 (ISOFORM 1).
RG   The European IMAGE consortium;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6P2C0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P2C0-2; Sequence=VSP_031512;
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DR   EMBL; AK097525; BAC05088.1; -; mRNA.
DR   EMBL; CH471101; EAX02063.1; -; Genomic_DNA.
DR   EMBL; BC064626; AAH64626.1; -; mRNA.
DR   EMBL; AL390084; CAB98208.1; -; mRNA.
DR   EMBL; AL390085; CAB98209.1; -; mRNA.
DR   CCDS; CCDS32326.1; -. [Q6P2C0-1]
DR   CCDS; CCDS66862.1; -. [Q6P2C0-2]
DR   RefSeq; NP_001271324.1; NM_001284395.1. [Q6P2C0-2]
DR   RefSeq; NP_001271325.1; NM_001284396.1.
DR   RefSeq; NP_064597.1; NM_020212.1. [Q6P2C0-1]
DR   AlphaFoldDB; Q6P2C0; -.
DR   BioGRID; 121285; 1.
DR   STRING; 9606.ENSP00000268130; -.
DR   iPTMnet; Q6P2C0; -.
DR   PhosphoSitePlus; Q6P2C0; -.
DR   BioMuta; WDR93; -.
DR   DMDM; 74737189; -.
DR   EPD; Q6P2C0; -.
DR   jPOST; Q6P2C0; -.
DR   MassIVE; Q6P2C0; -.
DR   PaxDb; Q6P2C0; -.
DR   PeptideAtlas; Q6P2C0; -.
DR   PRIDE; Q6P2C0; -.
DR   ProteomicsDB; 66884; -. [Q6P2C0-1]
DR   ProteomicsDB; 66885; -. [Q6P2C0-2]
DR   Antibodypedia; 54557; 66 antibodies from 16 providers.
DR   DNASU; 56964; -.
DR   Ensembl; ENST00000268130.12; ENSP00000268130.7; ENSG00000140527.15. [Q6P2C0-1]
DR   Ensembl; ENST00000560294.5; ENSP00000453971.1; ENSG00000140527.15. [Q6P2C0-2]
DR   GeneID; 56964; -.
DR   KEGG; hsa:56964; -.
DR   MANE-Select; ENST00000268130.12; ENSP00000268130.7; NM_020212.2; NP_064597.1.
DR   UCSC; uc002boj.3; human. [Q6P2C0-1]
DR   CTD; 56964; -.
DR   DisGeNET; 56964; -.
DR   GeneCards; WDR93; -.
DR   HGNC; HGNC:26924; WDR93.
DR   HPA; ENSG00000140527; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_Q6P2C0; -.
DR   OpenTargets; ENSG00000140527; -.
DR   PharmGKB; PA162409188; -.
DR   VEuPathDB; HostDB:ENSG00000140527; -.
DR   eggNOG; ENOG502QW2J; Eukaryota.
DR   GeneTree; ENSGT00390000009995; -.
DR   HOGENOM; CLU_025331_0_0_1; -.
DR   InParanoid; Q6P2C0; -.
DR   OMA; VPWKPMF; -.
DR   OrthoDB; 900109at2759; -.
DR   PhylomeDB; Q6P2C0; -.
DR   TreeFam; TF336347; -.
DR   PathwayCommons; Q6P2C0; -.
DR   BioGRID-ORCS; 56964; 17 hits in 1070 CRISPR screens.
DR   ChiTaRS; WDR93; human.
DR   GenomeRNAi; 56964; -.
DR   Pharos; Q6P2C0; Tdark.
DR   PRO; PR:Q6P2C0; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q6P2C0; protein.
DR   Bgee; ENSG00000140527; Expressed in oviduct epithelium and 92 other tissues.
DR   ExpressionAtlas; Q6P2C0; baseline and differential.
DR   Genevisible; Q6P2C0; HS.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR006885; NADH_UbQ_FeS_4_mit.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12219; PTHR12219; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; WD repeat.
FT   CHAIN           1..686
FT                   /note="WD repeat-containing protein 93"
FT                   /id="PRO_0000319603"
FT   REPEAT          410..449
FT                   /note="WD"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         443..470
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_031512"
FT   VARIANT         66
FT                   /note="L -> H (in dbSNP:rs4287542)"
FT                   /id="VAR_039017"
FT   VARIANT         254
FT                   /note="S -> T (in dbSNP:rs7163367)"
FT                   /id="VAR_039018"
FT   VARIANT         352
FT                   /note="T -> M (in dbSNP:rs7178234)"
FT                   /id="VAR_039019"
FT   CONFLICT        343
FT                   /note="R -> G (in Ref. 1; BAC05088)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        553
FT                   /note="K -> R (in Ref. 1; BAC05088)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        556
FT                   /note="Missing (in Ref. 4; CAB98209/CAB98208)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   686 AA;  77378 MW;  7838E1EFE6BDCE3A CRC64;
     MSFPRGSQTQ KIKHPIGTRK GPLEVPPPTE KDWPKDDEQD HVLVDPDEEL DSLPQPYRMI
     NKLVNLLFDQ SWEIIEERNA LREAESSQIQ PTVYPPLGEI QLNKMPNCMA VSQDYVFIGG
     AKGFSIYNLY SAKQIYAWEK LKVDVTSIWA TDLGNEILIA PVDEMGIIRL FYFYKEGLYL
     VKAINEVDDT SKQTTCIKME ISQGGDFAAF LLQGAGDIWL DVYKLPKETW LKKLEHPQLT
     SNPKKKVRQP QLNSLGPISA DPLEMDANVS FKGDIKLSLP VYIMKIKPPK PVTGTTFKSP
     LEVFAKIKDC YGLGSGQNHF IKDSQWEQQA EIFNASYKKY LDREWEEEPL STATFYFLLP
     SCLFAMPPEV KGPSGMACVL GIHWTRSHNF FLYSLNRTLK DKADPEGVWP CAAPIAVSQL
     SCSSSYLVLA CEDGVLTLWD LAKGFPLGVA ALPQGCFCQS IHFLKYFSVH KGQNMYPEGQ
     VKSQMKCVVL CTDASLHLVE ASGTQGPTIS VLVERPVKHL DKTICAVAPV PALPGMVLIF
     SKNGSVCLMD VAKREIICAF APPGAFPLEV PWKPVFAVSP DHPCFLLRGD YSHETASTDD
     AGIQYSVFYF NFEACPLLEN ISKNCTIPQR DLDNMAFPQA LPLEKRCERF LQKSYRKLEK
     NPEKEEEHWA RLQRYSLSLQ RENFKK
 
 
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