WDR93_HUMAN
ID WDR93_HUMAN Reviewed; 686 AA.
AC Q6P2C0; Q8N7Y8; Q9NP89;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=WD repeat-containing protein 93;
GN Name=WDR93;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 306-686 (ISOFORM 1).
RG The European IMAGE consortium;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P2C0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P2C0-2; Sequence=VSP_031512;
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DR EMBL; AK097525; BAC05088.1; -; mRNA.
DR EMBL; CH471101; EAX02063.1; -; Genomic_DNA.
DR EMBL; BC064626; AAH64626.1; -; mRNA.
DR EMBL; AL390084; CAB98208.1; -; mRNA.
DR EMBL; AL390085; CAB98209.1; -; mRNA.
DR CCDS; CCDS32326.1; -. [Q6P2C0-1]
DR CCDS; CCDS66862.1; -. [Q6P2C0-2]
DR RefSeq; NP_001271324.1; NM_001284395.1. [Q6P2C0-2]
DR RefSeq; NP_001271325.1; NM_001284396.1.
DR RefSeq; NP_064597.1; NM_020212.1. [Q6P2C0-1]
DR AlphaFoldDB; Q6P2C0; -.
DR BioGRID; 121285; 1.
DR STRING; 9606.ENSP00000268130; -.
DR iPTMnet; Q6P2C0; -.
DR PhosphoSitePlus; Q6P2C0; -.
DR BioMuta; WDR93; -.
DR DMDM; 74737189; -.
DR EPD; Q6P2C0; -.
DR jPOST; Q6P2C0; -.
DR MassIVE; Q6P2C0; -.
DR PaxDb; Q6P2C0; -.
DR PeptideAtlas; Q6P2C0; -.
DR PRIDE; Q6P2C0; -.
DR ProteomicsDB; 66884; -. [Q6P2C0-1]
DR ProteomicsDB; 66885; -. [Q6P2C0-2]
DR Antibodypedia; 54557; 66 antibodies from 16 providers.
DR DNASU; 56964; -.
DR Ensembl; ENST00000268130.12; ENSP00000268130.7; ENSG00000140527.15. [Q6P2C0-1]
DR Ensembl; ENST00000560294.5; ENSP00000453971.1; ENSG00000140527.15. [Q6P2C0-2]
DR GeneID; 56964; -.
DR KEGG; hsa:56964; -.
DR MANE-Select; ENST00000268130.12; ENSP00000268130.7; NM_020212.2; NP_064597.1.
DR UCSC; uc002boj.3; human. [Q6P2C0-1]
DR CTD; 56964; -.
DR DisGeNET; 56964; -.
DR GeneCards; WDR93; -.
DR HGNC; HGNC:26924; WDR93.
DR HPA; ENSG00000140527; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q6P2C0; -.
DR OpenTargets; ENSG00000140527; -.
DR PharmGKB; PA162409188; -.
DR VEuPathDB; HostDB:ENSG00000140527; -.
DR eggNOG; ENOG502QW2J; Eukaryota.
DR GeneTree; ENSGT00390000009995; -.
DR HOGENOM; CLU_025331_0_0_1; -.
DR InParanoid; Q6P2C0; -.
DR OMA; VPWKPMF; -.
DR OrthoDB; 900109at2759; -.
DR PhylomeDB; Q6P2C0; -.
DR TreeFam; TF336347; -.
DR PathwayCommons; Q6P2C0; -.
DR BioGRID-ORCS; 56964; 17 hits in 1070 CRISPR screens.
DR ChiTaRS; WDR93; human.
DR GenomeRNAi; 56964; -.
DR Pharos; Q6P2C0; Tdark.
DR PRO; PR:Q6P2C0; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q6P2C0; protein.
DR Bgee; ENSG00000140527; Expressed in oviduct epithelium and 92 other tissues.
DR ExpressionAtlas; Q6P2C0; baseline and differential.
DR Genevisible; Q6P2C0; HS.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR006885; NADH_UbQ_FeS_4_mit.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12219; PTHR12219; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; WD repeat.
FT CHAIN 1..686
FT /note="WD repeat-containing protein 93"
FT /id="PRO_0000319603"
FT REPEAT 410..449
FT /note="WD"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 443..470
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031512"
FT VARIANT 66
FT /note="L -> H (in dbSNP:rs4287542)"
FT /id="VAR_039017"
FT VARIANT 254
FT /note="S -> T (in dbSNP:rs7163367)"
FT /id="VAR_039018"
FT VARIANT 352
FT /note="T -> M (in dbSNP:rs7178234)"
FT /id="VAR_039019"
FT CONFLICT 343
FT /note="R -> G (in Ref. 1; BAC05088)"
FT /evidence="ECO:0000305"
FT CONFLICT 553
FT /note="K -> R (in Ref. 1; BAC05088)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="Missing (in Ref. 4; CAB98209/CAB98208)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 77378 MW; 7838E1EFE6BDCE3A CRC64;
MSFPRGSQTQ KIKHPIGTRK GPLEVPPPTE KDWPKDDEQD HVLVDPDEEL DSLPQPYRMI
NKLVNLLFDQ SWEIIEERNA LREAESSQIQ PTVYPPLGEI QLNKMPNCMA VSQDYVFIGG
AKGFSIYNLY SAKQIYAWEK LKVDVTSIWA TDLGNEILIA PVDEMGIIRL FYFYKEGLYL
VKAINEVDDT SKQTTCIKME ISQGGDFAAF LLQGAGDIWL DVYKLPKETW LKKLEHPQLT
SNPKKKVRQP QLNSLGPISA DPLEMDANVS FKGDIKLSLP VYIMKIKPPK PVTGTTFKSP
LEVFAKIKDC YGLGSGQNHF IKDSQWEQQA EIFNASYKKY LDREWEEEPL STATFYFLLP
SCLFAMPPEV KGPSGMACVL GIHWTRSHNF FLYSLNRTLK DKADPEGVWP CAAPIAVSQL
SCSSSYLVLA CEDGVLTLWD LAKGFPLGVA ALPQGCFCQS IHFLKYFSVH KGQNMYPEGQ
VKSQMKCVVL CTDASLHLVE ASGTQGPTIS VLVERPVKHL DKTICAVAPV PALPGMVLIF
SKNGSVCLMD VAKREIICAF APPGAFPLEV PWKPVFAVSP DHPCFLLRGD YSHETASTDD
AGIQYSVFYF NFEACPLLEN ISKNCTIPQR DLDNMAFPQA LPLEKRCERF LQKSYRKLEK
NPEKEEEHWA RLQRYSLSLQ RENFKK