WDR97_HUMAN
ID WDR97_HUMAN Reviewed; 1622 AA.
AC A6NE52; Q96JF2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=WD repeat-containing protein 97 {ECO:0000312|HGNC:HGNC:26959};
GN Name=WDR97 {ECO:0000312|HGNC:HGNC:26959}; Synonyms=KIAA1875;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS GLY-149
RP AND GLY-537.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NE52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NE52-2; Sequence=VSP_033425, VSP_033426;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47504.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB058778; BAB47504.1; ALT_SEQ; mRNA.
DR EMBL; AC104592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS83334.1; -. [A6NE52-1]
DR RefSeq; NP_001303238.1; NM_001316309.1. [A6NE52-1]
DR AlphaFoldDB; A6NE52; -.
DR IntAct; A6NE52; 3.
DR STRING; 9606.ENSP00000320648; -.
DR iPTMnet; A6NE52; -.
DR PhosphoSitePlus; A6NE52; -.
DR BioMuta; WDR97; -.
DR MassIVE; A6NE52; -.
DR PaxDb; A6NE52; -.
DR PeptideAtlas; A6NE52; -.
DR PRIDE; A6NE52; -.
DR ProteomicsDB; 959; -. [A6NE52-1]
DR Antibodypedia; 71324; 5 antibodies from 5 providers.
DR Ensembl; ENST00000323662.9; ENSP00000320648.8; ENSG00000179698.14. [A6NE52-1]
DR GeneID; 340390; -.
DR KEGG; hsa:340390; -.
DR MANE-Select; ENST00000323662.9; ENSP00000320648.8; NM_001316309.2; NP_001303238.1.
DR UCSC; uc064riy.1; human. [A6NE52-1]
DR CTD; 340390; -.
DR GeneCards; WDR97; -.
DR HGNC; HGNC:26959; WDR97.
DR HPA; ENSG00000179698; Tissue enriched (testis).
DR neXtProt; NX_A6NE52; -.
DR OpenTargets; ENSG00000179698; -.
DR VEuPathDB; HostDB:ENSG00000179698; -.
DR eggNOG; KOG0321; Eukaryota.
DR GeneTree; ENSGT00940000164199; -.
DR HOGENOM; CLU_244603_0_0_1; -.
DR InParanoid; A6NE52; -.
DR OMA; WKVPDMV; -.
DR OrthoDB; 313028at2759; -.
DR PhylomeDB; A6NE52; -.
DR PathwayCommons; A6NE52; -.
DR SignaLink; A6NE52; -.
DR BioGRID-ORCS; 340390; 1 hit in 123 CRISPR screens.
DR GenomeRNAi; 340390; -.
DR Pharos; A6NE52; Tdark.
DR PRO; PR:A6NE52; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; A6NE52; protein.
DR Bgee; ENSG00000179698; Expressed in left testis and 84 other tissues.
DR ExpressionAtlas; A6NE52; baseline and differential.
DR Genevisible; A6NE52; HS.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1622
FT /note="WD repeat-containing protein 97"
FT /id="PRO_0000332994"
FT REPEAT 187..233
FT /note="WD 1"
FT REPEAT 290..329
FT /note="WD 2"
FT REPEAT 331..370
FT /note="WD 3"
FT REPEAT 552..592
FT /note="WD 4"
FT REPEAT 594..633
FT /note="WD 5"
FT REPEAT 687..726
FT /note="WD 6"
FT REGION 1090..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1094..1118
FT /evidence="ECO:0000255"
FT COMPBIAS 1098..1112
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 809..837
FT /note="SEALSLIHRRRATSQHLVPKEDLDAIVAR -> RSHGGLLSPPGGPPFPLWV
FT GAWRCGALWS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_033425"
FT VAR_SEQ 838..1622
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_033426"
FT VARIANT 149
FT /note="R -> G (in dbSNP:rs4977196)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_043029"
FT VARIANT 427
FT /note="H -> Q (in dbSNP:rs34324679)"
FT /id="VAR_043030"
FT VARIANT 537
FT /note="E -> G (in dbSNP:rs13250446)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_043031"
FT CONFLICT 430
FT /note="V -> L (in Ref. 1; BAB47504)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1622 AA; 180307 MW; 3991010D04BFD01A CRC64;
MEAEVWEAEG YNLVLDSDLY DADGYDVPDP GLLTEKNELT FTEPSQVLPF LTSSQQWQSL
TPRARARRLW LLLRTSLHEV VEKEKRAELR AARLTHGLEP LRRLEVAAGL RSVAQDPVGG
RFVVLDGAGR LHLHKEDGWA QETLLAPVRL TGLVTVLGPL GAVGRFVGWG PAGLAILRPN
LSLLWLSEQG VGRAPGWAPT CCLPVPDLRL LLVAEMNSSL ALWQFRSGGR RLVLRGSALH
PPPSPTGRLM RLAVAPVPPH HVLRCFAAYG SAVLTFDLHA WTLVDVRRDL HKTTISDLAY
CEEVEAMVTA SRDSTVKVWE ADWQIRMVFV GHTGPVTAMT VLPNTTLVLS ASQDGTLRTW
DLQAAAQVGE VALGFWGQDK LSRRVGRLLA PVRPGWPVLS LCASSMQLWR VRELYSPLAQ
LPAKVLHVQV APALPAPAHQ SLPTRLVCAC ADGSVYLLSA ATGRIVSSLL LEPEDCAAAV
AYCLPREALW LLTRAGHLVR ANAARCPMSV LHRVCPPPPP APQPCCLHLY SHLTDLEGAF
SSWEIVRQHW GELRCSSVAC AWKNKNRYLP VVGHTDGTLS VLEWLSSKTV FQTEAHSPGP
VVAIASTWNS IVSSGGDLTV KMWRVFPYAE ESLSLLRTFS CCYPAVALCA LGRRVTAGFE
DPDSATYGLV QFGLGDSPRL DHRPQDDPTD HITGLCCCPT LKLYACSSLD CTVRIWTAEN
RLLRLLQLNG APQALAFCSN SGDLVLALGS RLCLVSHRLY LPTSYLVKKM CRKAPDVVDD
PPLPLMSQES LTSAQLQRLT NLHGAASLSE ALSLIHRRRA TSQHLVPKED LDAIVARDRD
LQQLRLGLVV PAAQPPPSWQ QRQEGFDNYL RLIYGSGLLG MQSGRGSQQW SAGTLRVERE
TRDVCAVPQA AHCLARAEVS TAAQTVPTAL SPQDLGALGQ HFSQSPRVTV PIPPTHRRVH
SKASQLLARS SLSHYLGISL DLQLQLEQLR GRTTMALDLP SSHLQCRIPL LPKRWDKEPL
SSLRGFFPAT VQPHKHCLRP ICFPGYVPNS AVLQQMWLNA EPGASQDALW LWRPRPSQTQ
WQRKLLQWMG EKPGEEGEED KKEEEEEKED EELDWALASL SPHSNQQLDS WELEDQSAVD
WTQEPRRRSC KVARTHPHPW HRHGSLLLDE HYGHLPKFLH FFIYQTWFKK LFPIFSLQAY
PEAGTIEGLA SLLVALLEKT TWVDRVHILQ VLLRLLPNMS SDLQGQLQGL LVHLLNLDQP
PSLQDQTQKK FVILALQLLL ACSLESRDVV LELMSYFLYS PVHCRPELKK LLHGLGLQDP
EGFLFKEMMT WVQGPDLDSK AGLRTCCHQK LEDMIQELQE TPSQTSVVSG APTRASVIPS
GTSWSASGIF GRLSQVSEVP LMVVSPAEPH SLAPELQAQR MLAPKRSWGT PQLRLRVLSE
TLKSFCLEPE ARLHPAGPAQ LPGEPPPLEE TDWSHSQLLD LGPIDALNFF CEQLRAQQRS
SLQEKAAHPH PPEPYTVAPV PDMVVPPPRE HWYHPILRLQ EAKPQRSARS AMRLRGPMRS
RLCAGRTLDG PIRTLKLPLP RVEPQPFPLD WPMPPRPLPP RLLQPALQRY FLPADADPDT
YS
