WDS_ARATH
ID WDS_ARATH Reviewed; 523 AA.
AC Q9FND4; Q93ZU7;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=WD repeat-containing protein WDS homolog {ECO:0000305};
DE AltName: Full=Protein will die slowly homolog {ECO:0000305};
GN Name=WDS {ECO:0000312|EMBL:ABQ85545.1};
GN OrderedLocusNames=At5g43920 {ECO:0000312|Araport:AT5G43920};
GN ORFNames=MRH10.1 {ECO:0000312|EMBL:BAB09052.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Xiong X., Sun S., Halim T.A., Halim V.A., Kobaisy M., Xing T.;
RT "Will die slowly gene in Arabidopsis senescence and disease resistance.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RANBPM, AND
RP SUBCELLULAR LOCATION.
RX PubMed=22676313; DOI=10.1186/1471-2229-12-83;
RA Tomastikova E., Cenklova V., Kohoutova L., Petrovska B., Vachova L.,
RA Halada P., Kocarova G., Binarova P.;
RT "Interactions of an Arabidopsis RanBPM homologue with LisH-CTLH domain
RT proteins revealed high conservation of CTLH complexes in eukaryotes.";
RL BMC Plant Biol. 12:83-83(2012).
CC -!- SUBUNIT: Interacts with RANBPM. {ECO:0000269|PubMed:22676313}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22676313}.
CC Note=Associates predominantly in the form of large cytoplasmic
CC complexes. {ECO:0000269|PubMed:22676313}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL07102.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; EF601122; ABQ85545.1; -; Genomic_DNA.
DR EMBL; AB006703; BAB09052.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95028.1; -; Genomic_DNA.
DR EMBL; AY056253; AAL07102.1; ALT_FRAME; mRNA.
DR EMBL; AK227235; BAE99272.1; -; mRNA.
DR RefSeq; NP_199205.1; NM_123759.3.
DR AlphaFoldDB; Q9FND4; -.
DR SMR; Q9FND4; -.
DR STRING; 3702.AT5G43920.1; -.
DR PaxDb; Q9FND4; -.
DR PRIDE; Q9FND4; -.
DR ProMEX; Q9FND4; -.
DR ProteomicsDB; 242765; -.
DR EnsemblPlants; AT5G43920.1; AT5G43920.1; AT5G43920.
DR GeneID; 834414; -.
DR Gramene; AT5G43920.1; AT5G43920.1; AT5G43920.
DR KEGG; ath:AT5G43920; -.
DR Araport; AT5G43920; -.
DR TAIR; locus:2172432; AT5G43920.
DR eggNOG; KOG0293; Eukaryota.
DR HOGENOM; CLU_000288_57_25_1; -.
DR InParanoid; Q9FND4; -.
DR OMA; KHEFIRI; -.
DR OrthoDB; 349428at2759; -.
DR PhylomeDB; Q9FND4; -.
DR PRO; PR:Q9FND4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FND4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..523
FT /note="WD repeat-containing protein WDS homolog"
FT /id="PRO_0000442059"
FT DOMAIN 16..48
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT DOMAIN 49..107
FT /note="CTLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT REPEAT 222..261
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 267..306
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 310..353
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 355..394
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 395..434
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 438..480
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 483..523
FT /note="WD 7"
FT /evidence="ECO:0000255"
SQ SEQUENCE 523 AA; 59122 MW; AA80BFB95C4F5577 CRC64;
MENGLWEVLG SKGLLKKHEF IRILVQCLYS LGFKNSASCL EFESKILYKT ADSEFLEKQV
LSGNWDSCVQ VLDRIFDNSM DDTRNTALYL VFKQCLLEYL KRGDVSLALN VLRKQAPLLR
MGKEKIHRLA CDIVYSKEME SGEVDNCLVL DLRRKLLVEL EKLIPLPIVI PERRLEHLVE
TAVMDQIDTC MYHNSCDAVS LYKDHCCGRD QIPSETVQIL VAHKNEVWFV QFSNSGKYLA
TASSDCTAII WKVLDDNKVE LKHTLESHQN PVSFVSWSPD DTKLLTCGNA EVLKLWDVDT
GVLRHTFGNN NTGFTVSSCA WFPDSTRLVC GSSDPERGIV MWDTDGNEIK AWRGTRIPKV
VDLAVTPDGE SMITVFSDKE IRILNLETKV ERVISEEQPI TSLSISGDGK FFIVNLSCQE
IHLWDLAGEW KQPLKFSGHR QSKYVIRSCF GGLDSSFIAS GSEDSQVYIW NLKNTKPLEV
LSGHSMTVNC VSWNPKNPRM LASASDDQTI RIWGPGKPNK PLN
