WDTC1_MOUSE
ID WDTC1_MOUSE Reviewed; 677 AA.
AC Q80ZK9;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=WD and tetratricopeptide repeats protein 1;
GN Name=Wdtc1; Synonyms=Gm695;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Brain, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
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DR EMBL; BC048824; AAH48824.1; -; mRNA.
DR EMBL; BC057107; AAH57107.1; -; mRNA.
DR CCDS; CCDS18746.1; -.
DR RefSeq; NP_955010.1; NM_199306.4.
DR RefSeq; XP_006538806.1; XM_006538743.3.
DR RefSeq; XP_006538807.1; XM_006538744.3.
DR AlphaFoldDB; Q80ZK9; -.
DR BioGRID; 231030; 436.
DR IntAct; Q80ZK9; 1.
DR STRING; 10090.ENSMUSP00000040647; -.
DR iPTMnet; Q80ZK9; -.
DR PhosphoSitePlus; Q80ZK9; -.
DR EPD; Q80ZK9; -.
DR jPOST; Q80ZK9; -.
DR MaxQB; Q80ZK9; -.
DR PaxDb; Q80ZK9; -.
DR PeptideAtlas; Q80ZK9; -.
DR PRIDE; Q80ZK9; -.
DR ProteomicsDB; 275215; -.
DR Antibodypedia; 30730; 131 antibodies from 20 providers.
DR Ensembl; ENSMUST00000043305; ENSMUSP00000040647; ENSMUSG00000037622.
DR GeneID; 230796; -.
DR KEGG; mmu:230796; -.
DR UCSC; uc008vcr.2; mouse.
DR CTD; 23038; -.
DR MGI; MGI:2685541; Wdtc1.
DR VEuPathDB; HostDB:ENSMUSG00000037622; -.
DR eggNOG; KOG1310; Eukaryota.
DR eggNOG; KOG1334; Eukaryota.
DR GeneTree; ENSGT00950000182900; -.
DR HOGENOM; CLU_012381_3_1_1; -.
DR InParanoid; Q80ZK9; -.
DR OMA; HWQRQQY; -.
DR OrthoDB; 1270484at2759; -.
DR PhylomeDB; Q80ZK9; -.
DR TreeFam; TF320710; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 230796; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Wdtc1; mouse.
DR PRO; PR:Q80ZK9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80ZK9; protein.
DR Bgee; ENSMUSG00000037622; Expressed in hindlimb stylopod muscle and 239 other tissues.
DR ExpressionAtlas; Q80ZK9; baseline and differential.
DR Genevisible; Q80ZK9; MM.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0004857; F:enzyme inhibitor activity; IDA:MGI.
DR GO; GO:0042393; F:histone binding; IDA:MGI.
DR GO; GO:0042826; F:histone deacetylase binding; IPI:MGI.
DR GO; GO:0055082; P:cellular chemical homeostasis; IMP:MGI.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IMP:MGI.
DR GO; GO:0006006; P:glucose metabolic process; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0008361; P:regulation of cell size; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR045151; DCAF8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15574; PTHR15574; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00028; TPR; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..677
FT /note="WD and tetratricopeptide repeats protein 1"
FT /id="PRO_0000051435"
FT REPEAT 45..84
FT /note="WD 1"
FT REPEAT 88..129
FT /note="WD 2"
FT REPEAT 132..172
FT /note="WD 3"
FT REPEAT 182..222
FT /note="WD 4"
FT REPEAT 265..305
FT /note="WD 5"
FT REPEAT 361..394
FT /note="TPR 1"
FT REPEAT 396..431
FT /note="TPR 2"
FT REPEAT 535..575
FT /note="WD 6"
FT REPEAT 578..617
FT /note="WD 7"
FT REGION 489..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5D0"
FT MOD_RES 511
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 677 AA; 75733 MW; CDB5F09E80E6C625 CRC64;
MAKVNITRDL IRRQVKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD
LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD
LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY
CGPMVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMRQSPSA GVHTFCDRQK
PLPDGAAQYY VAGHLPVKLP DYNSRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK
QRPYTFLLPR KCHSVEVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESKGC ISPQVELPPY
LERVKQQANE AFACQQWTQA IQLYSQAVQK APHNAMLYGN RAAAYMKRKW DGDHYDALRD
CLKAISLNPC HLKAHFRLAR CLFELKYVAE ALECLDDFKG KFPEQAHSSA CDALGRDITA
ALFSKSDGEE KKAAGGGGGP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI
KEANFFGSNA QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI
DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNANPL EAMLLDMGYR ITGLSSGGAG
ASDDEDSAEG QVQCRPS
