ID   WDY_AEDAE               Reviewed;        1037 AA.
AC   Q17I16;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000250|UniProtKB:B4F7L9};
DE            Short=WD40 Y {ECO:0000250|UniProtKB:B4F7L9};
GN   Name=WDY {ECO:0000250|UniProtKB:B4F7L9}; ORFNames=AAEL002485;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT46343.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
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DR   EMBL; CH477243; EAT46343.1; -; Genomic_DNA.
DR   RefSeq; XP_001655383.1; XM_001655333.1.
DR   AlphaFoldDB; Q17I16; -.
DR   STRING; 7159.AAEL002485-PA; -.
DR   GeneID; 5574823; -.
DR   KEGG; aag:5574823; -.
DR   VEuPathDB; VectorBase:AAEL002485; -.
DR   eggNOG; KOG0285; Eukaryota.
DR   HOGENOM; CLU_006741_0_1_1; -.
DR   InParanoid; Q17I16; -.
DR   OMA; YIYAWSL; -.
DR   OrthoDB; 774295at2759; -.
DR   PhylomeDB; Q17I16; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1037
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000377418"
FT   REPEAT          122..162
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          171..210
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          343..382
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          386..425
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          475..514
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          527..568
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          615..657
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          716..755
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          762..801
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          845..884
FT                   /note="WD 10"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1037 AA;  118911 MW;  0F8047328692EE51 CRC64;
     MDSIEEADTS HPQLLHRYLS QNDVEHLYRI FNKRKQLLPE ELRTELTDLT GVEFQDEEFQ
     TLFMKINANK DEYCQWDELV SYLILGFQND DPLAVQESLD LPISQDMGMK LGRQTYPVTK
     IQYAPLVSYD GTVNWSQGFW VTSTREAVIN FWKRDWKHLK TGKAFSVDLK RIKTMVLDTA
     ILPDQNYFCV ACLECELRFY DIIASGFTLK TIINRIPNAI NSLYYHFSPD TRSKMILGDY
     VGHVRMIEFF PENKEPFKFD AATAITRMAF CDLVGGLCPQ MTCVDYGRLL PDIVRQVEFI
     ESRNSFVACS ENDPLVPHHM RNKLQVSLVI QHTRKLDRRT KFKVFKGVTC FAFDSIKDFL
     VTGGPDGQLR LWDSRRSDKP TEILAGHNSA VVFMFLQDES LKLYSMDQKK IVKIWDVPNR
     TLIQTYSQFS SSMFKTVPAC AYYSELNREL VVGANKVLSV SCCPKIALEV TDGESHTQPI
     SVLLHNPLFK VIVSCGLDSF IIVWDYTGNR KLTIIQDAHT EVIHGILEKV QITAACFDPK
     LQLMVTGARN GELKIWNFNS GSLMSCMSIG SECEVTAVFW ERTGILAMGW NHVIVEFPVG
     STGIDFPSGV EWQKLHSDDI LCASINRTEP KALASCSYSG EIILWMLETG QAYKRFDAAK
     PRQKIPVNFK KKRIPQPTRR QTRLSIFQPQ EHWRQRRLTR IVMPATAELL RQLTIHNLLF
     LEARPFHPDY GTLLASLDTG RILVFSHHPD GGYMGAFSAV HMAGDRVIMM TTDSDNRFLF
     TGTYLGYIKI WLLENYFVPS GKQPKVNRAA LRLQFPFLMD DVVPGRAKRS VANQPMPMLL
     SSYQAHRTCV TDLVYMHASQ LLVSASSDRT IRIWTISGRY VGLLGSPVKW PTLDPDHPIA
     RNYNFRIPPD LHREVSFTTA QVLRGGERFI KFKSRILQEA SERRRTEAIE TYGKPLEPPY
     LNTATFPYGP HTSYHPDPKL DFSFRQTPIF EHLSIPNLLK MKPVDSEKVL RDAKQLNFSN
     DGDRIDSYHE KKDNIFK