ID   WDY_ANOGA               Reviewed;        1059 AA.
AC   Q5TTP0;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 4.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000250|UniProtKB:B4F7L9};
DE            Short=WD40 Y {ECO:0000250|UniProtKB:B4F7L9};
GN   Name=WDY {ECO:0000250|UniProtKB:B4F7L9}; ORFNames=AGAP002309;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
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DR   EMBL; AAAB01008859; EAL40950.4; -; Genomic_DNA.
DR   RefSeq; XP_563902.4; XM_563902.4.
DR   AlphaFoldDB; Q5TTP0; -.
DR   STRING; 7165.AGAP002309-PA; -.
DR   PaxDb; Q5TTP0; -.
DR   PRIDE; Q5TTP0; -.
DR   GeneID; 3290597; -.
DR   KEGG; aga:AgaP_AGAP002309; -.
DR   CTD; 3290597; -.
DR   VEuPathDB; VectorBase:AGAP002309; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   HOGENOM; CLU_006741_0_1_1; -.
DR   InParanoid; Q5TTP0; -.
DR   OMA; YIYAWSL; -.
DR   OrthoDB; 774295at2759; -.
DR   PhylomeDB; Q5TTP0; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1059
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000377419"
FT   REPEAT          121..161
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          170..209
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          214..256
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          344..383
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          387..426
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          476..515
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          528..567
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          616..658
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          714..759
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          766..805
FT                   /note="WD 10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          849..888
FT                   /note="WD 11"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1059 AA;  119800 MW;  0702E89E0C86CCC0 CRC64;
     MAGRLSTADA DREIHRFVTR EQIDQLHEQF RARNNRLTLD ELRELLAELG LFYTEDEYRT
     LCLQINTDHD RYCQWDELLS YLILGFQDDD PHAVKQSLDP PIAGDLCVKL RRQVYNIVKV
     DFCPMVYYDG SISWSQGHWI TTSREGVIQY WTEDWKPALT ARSVPSSLKR SKTWVLDTVP
     LPDLSMFCVT GLETELRLYN VVAACFTLKL VIERLPQPIS AMAYRFGRDE PSRLLTGDYT
     GHIRMFVFHP ERKVTTSGES TVTHVSLQDV LHGAYPPVEC VDYGQLLPDI VRAVQFVESV
     GNVAELFIAC AEENPLLSSA RGRPRPAMVI HSLDLPAIRR IKFCVPRGVT CFAFEPSNEL
     LVSGGPDCDL RLWDIHRPEK PSVVLVGHTS SITFLFLQDA GEKIYSLDQR KIIKVWDVRN
     RVLLQTFGQF STVLVKGVPA CAYYNKRARE LVVASNKLFV TACCPEIALD RTDGESHTKP
     VSVLLYNGLY RLVVSCGFDS FIIVWDHRVN RKMTIITEAH TQIRNGVLEP VEITAACFDG
     KEQMLLTGAR NGSLKIWNIG GRTCMRTIQI EEDCEVTGVF WQANRILAMG WNHRVVEFAA
     FAEQDEYPRG LQWRKQHSDD ILCAAVSGSE PGVMATCSYA GELVFWMLET GQPYRRYDAT
     NPRTRLPISF REGRADLMKP RKLTPRRSLF QMPPGQLAHR RLTRILMPSG LEQMRQLSIQ
     ALLFLAMRKM LPDRGTLFGS LDNGMVQVWS HHPDGGFKGQ FNGIHMAGDR IITLATDKAN
     RFLFTGTALG YVKTWYIENC WIPNEDKFHV NKPALRILFP FLLNDVVPGR AKRSARAQVK
     PWLLNSYQAH RACVTGLTYL DDTGLLLSCS SDRTVRLWTL GGRYIGLLGS PVNWQPLPMA
     VPPPADYRFR IPPDLQREVS FTTLKVLRGG KDSSRTARTK SGGGTATVGD IVGVAADRSK
     HTPMIETYGS PLAEPILNTA VLKLPSKEPM LQTIKLDRTY PSFPLYRHMV AFPVQPLKRT
     NKTVEENGSD WNELEQLLER TKALQFKDAP SDADAEGTQ