ID   WDY_DROGR               Reviewed;        1171 AA.
AC   B7FF06; B4JBK9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000303|PubMed:19011613, ECO:0000312|EMBL:DAA06440.1};
DE            Short=WD40 Y {ECO:0000303|PubMed:19011613};
GN   Name=WDY {ECO:0000312|EMBL:DAA06440.1}; ORFNames=GH17261;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDW04032.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000269|PubMed:17994087};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06440.1}
RP   IDENTIFICATION.
RX   PubMed=19011613; DOI=10.1038/nature07463;
RA   Koerich L.B., Wang X., Clark A.G., Carvalho A.B.;
RT   "Low conservation of gene content in the Drosophila Y chromosome.";
RL   Nature 456:949-951(2008).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW04032.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH916368; EDW04032.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006443; DAA06440.1; -; Genomic_DNA.
DR   RefSeq; XP_001989165.1; XM_001989129.1.
DR   AlphaFoldDB; B7FF06; -.
DR   STRING; 7222.FBpp0151167; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   InParanoid; B7FF06; -.
DR   ChiTaRS; WDY; fly.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1171
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000378996"
FT   REPEAT          157..201
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          331..370
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          374..413
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          464..503
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          516..555
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          603..643
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          748..787
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          831..870
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REGION          1076..1171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1076..1107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1141..1171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1171 AA;  132434 MW;  FE4257FBA26C3709 CRC64;
     MSMVYLASGD SNANIEYQTI SSTATQQLTQ EQSERLHDRI TKAQLQKLYD LFKSSPDQMV
     GYSELRHMLE DVDITFTDYT YTRLFLKINQ NSDFMIDWNE FVSYLIFGFQ EEDPSSQKEA
     LTMPISAPPV VRKTEHRSAV CCITLLKVKS DQTPMEEIPE LSANYSFGGE DSPENSGMWV
     TASREGQLRF WSAHMEPLRS AVSESSNLPY AVYCMSYAFY NNGKTHSKLV LGDYAGNVRI
     LSYSPYLRGP FQAKPGAALV ELVWADVLKG RIPLLIPREH INLHSELISC VYYSLHMNTL
     FASAEYRNTK KYRGRCPGLI MVSNDDRNNF RIPLGVSVFY VAESKNILVT GGPDTFVRIW
     DVYISSEPSA ILTGHNGGIV AVFVQPEENK VYSVDYHKVI KVWDLQEHTL LQTFGELVRI
     IHHSETDIKY YYHSHLRDLL VAGRKLIQIK CCPRVRVDLT DGNTHAAPVS VVLYNRLFRN
     IVTCGLDSYI IVWDPWTGRR KIIMKNCHTK MIYGEIIDIE ITAACFDPLE QFLLTGARDG
     SLKIWNYNNA VVVRNMSIQP DQEVTAVIWV IDRILAMGWD RQVTEFNDVA GREYGDPKKW
     AKFHTDDITC ADVKLGEGVV TATYSGEIIF WKLETGQPYR RYNVMNPYQF IELKLNTEEE
     KLTRRSKRIS SLMGAGRRTL VLQNFKPDEI KDYGANIPVS VQAVLFLQKR PMTKDHGSVF
     ISLDTGYIQV YSHHQHGGFI KQFFAVHKVG DCVLTMASDR KNRFLYTGTA FGYIKIWHIV
     NYCIPQAEKT EVCMPRLRLD FIFLRKDLFL TRAKRVIRNQ PEPMLVSSYK GHLKAINSIG
     FINLPKILFT GSHDYSCRLW TQGGRYLGTL GTVLPWSKLT PFERAGEDNR AYRLPPDIKK
     VASSTTLKVI SGIQHTGTVK RAKAVDERED ERDVEEAASD VKNMFDRPLR EPILGHHFQL
     PGRSVIEQRI DLDTTELCIP VYTHLRVYPS EMMEHLPTPP VIGQVRAENY LDHYMPVVGK
     VDPHDSAINI REPQKRAKAG SSSLLPARAG YSLGKPKTNS VLGMPRSSGA GLCKPRTSFT
     LSDYTPGNPK ADFSSRNMKS NLSSGSPKAG IPKADSSHGS AKASCRLGSP KPDYISIKKR
     ASFSPGTTPK TDFSPKAGKP KTNTMKSSNS H