WDY_DROME
ID WDY_DROME Reviewed; 1069 AA.
AC B4F7L9; A8QI03; A8QI24; A8QI78; Q5BHX3; Q7PLH6;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000303|PubMed:18660539, ECO:0000312|EMBL:DAA06296.1};
DE Short=WD40 Y {ECO:0000303|PubMed:18660539};
GN Name=WDY {ECO:0000312|FlyBase:FBgn0267449};
GN ORFNames=CG40245/CG40551/CG40583/CG41020 {ECO:0000312|FlyBase:FBgn0267449};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAX33599.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 477-1069.
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305, ECO:0000312|EMBL:DAA06296.1}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=18660539; DOI=10.1534/genetics.108.086819;
RG 12 Drosophila Genome Project;
RA Vibranovsky M.D., Koerich L.B., Carvalho A.B.;
RT "Two New Y-Linked Genes in Drosophila melanogaster.";
RL Genetics 179:2325-2327(2008).
RN [5] {ECO:0000305, ECO:0000312|EMBL:DAA06296.1}
RP IDENTIFICATION.
RX PubMed=19011613; DOI=10.1038/nature07463;
RA Koerich L.B., Wang X., Clark A.G., Carvalho A.B.;
RT "Low conservation of gene content in the Drosophila Y chromosome.";
RL Nature 456:949-951(2008).
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis and weakly in the
CC soma. {ECO:0000269|PubMed:18660539}.
CC -!- MISCELLANEOUS: Chromosome mapping suggests that WDY is fully contained
CC in the kl-1 region, and WDY may correspond to this fertility factor.
CC {ECO:0000269|PubMed:18660539}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA46315.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EDP27888.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EDP27942.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EDP27963.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CP007106; EAA46315.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP007106; EDP27963.2; ALT_SEQ; Genomic_DNA.
DR EMBL; DS483672; EDP27942.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP007106; EDP27888.2; ALT_SEQ; Genomic_DNA.
DR EMBL; BT021451; AAX33599.1; -; mRNA.
DR EMBL; BK006449; DAA06296.1; -; Genomic_DNA.
DR RefSeq; NP_001303588.1; NM_001316659.1.
DR AlphaFoldDB; B4F7L9; -.
DR STRING; 7227.FBpp0291686; -.
DR PaxDb; B4F7L9; -.
DR EnsemblMetazoa; FBtr0347028; FBpp0312450; FBgn0267449.
DR GeneID; 26067056; -.
DR KEGG; dme:Dmel_CG45799; -.
DR UCSC; CG40245-RA; d. melanogaster.
DR UCSC; CG40551-RA; d. melanogaster.
DR UCSC; CG40583-RA; d. melanogaster.
DR CTD; 26067056; -.
DR FlyBase; FBgn0267449; WDY.
DR VEuPathDB; VectorBase:FBgn0267449; -.
DR eggNOG; KOG0267; Eukaryota.
DR GeneTree; ENSGT00940000165779; -.
DR HOGENOM; CLU_006741_0_1_1; -.
DR InParanoid; B4F7L9; -.
DR OMA; YIYAWSL; -.
DR OrthoDB; 774295at2759; -.
DR BioGRID-ORCS; 26067056; 0 hits in 1 CRISPR screen.
DR ChiTaRS; WDY; fly.
DR GenomeRNAi; 26067056; -.
DR PRO; PR:B4F7L9; -.
DR Proteomes; UP000000803; Chromosome Y.
DR Bgee; FBgn0267449; Expressed in testis and 3 other tissues.
DR ExpressionAtlas; B4F7L9; differential.
DR Genevisible; B4F7L9; DM.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1069
FT /note="WD repeat-containing protein on Y chromosome"
FT /id="PRO_0000377422"
FT REPEAT 155..199
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 322..361
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 365..404
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 455..494
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 507..546
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 594..634
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 747..786
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 830..869
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REGION 664..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 121814 MW; BA860E2C779BDE52 CRC64;
MSVIFNASVN TKSAVEYQTI SSTQSHSAEE QSERLHKWIS KDQLEKLYSS FLNTPERHVG
IDELRIILEE LDITFNDSMY TRLFLKINQN RDFKVDWNEF VSYLIFGFQE EDPSSQKESL
ILPISGPPMV RKSEHRSAIC CLALLKAKSD QVPIDEVTET INFSFGGEDS PEASGMWVTA
SHEGMMRFWT SHMEPIRTAS SESICMSYAF FNNGKVHSKL ILGDYAGNVR VLSYSPHLRG
PFQAKPGAAL IEVVWSDILR GKIPQFFPKE YINLHNEMVS CVYFSLHMNA LFASAEYRNT
KKYRGRCPGM IMVTYDERSN FRIPLGVSTF FVAESHNIVV TGGPDTFVRI WDVYIPTEPS
AILTGHNGGI VLVFVQPEEN KVYSVDYQKI IKVWDLHEHT LLQTYGDLVR LIHHSETDLT
YYYHSHLREL VVAGRKLISI KCCPRVRVDL TDGNTHAAPV SVVLYNRLFR NIVSCGLDSY
IIVWDPWTGR RKIIMKSCHT KMIYGEIIDI EITAACFDPL EQFLLTGARD GSLKIWNYNN
AVVVRNMSIM PDQEVTAVIW VVDRILAMGW DRQVTEFNDV VGREYGDPKK WPKFHTDDIT
CADVKLGEGV VTATYSGEII FWKLETGQPY RRYSVMDPTR FIELKLTAEE EKFIRQSKRL
ASRLTHSGNH SLQTGRAGRS TVLNRPEDNR DYGTDIPISV QAVLFLQTRP QTLKHGSVFI
SLDTGFIQVY SHHQRGGYIV EFLAVHKTGD CVLTMCTDRK NRYLYTGTAF GYIKVWYIVN
FCVPESEKTH VCMPKLRLEF IFLRKELFMT RAKRAVRNQA EPLLVSSYKG HLKAINSIAF
INLPKIIFTG SHDYSCRLWT QGGRYLGTLG TVLPWSRLTP FERAGDDNHL YRMPPDIKKV
ASSTTLKVIS GIQAETSIKI SNGKTVEDRE EETAQTEDVT ELRKLLDKPV KEPIVGKHFE
LPGRSILDQH IELDTTQSYI AVFTQLKVHS TEMLERLPTP AVVSRVQTEN YMDHYIPVEG
KVDVSGSAIN IKQPSRRRSD KASDTRNVNT LGARDHVPLD FSSSHASQS
