ID   WDY_DROMO               Reviewed;        1217 AA.
AC   B7FF07; B4KHZ3;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000303|PubMed:19011613, ECO:0000312|EMBL:DAA06441.1};
DE            Short=WD40 Y {ECO:0000303|PubMed:19011613};
GN   Name=WDY {ECO:0000312|EMBL:DAA06441.1}; ORFNames=GI17063;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1] {ECO:0000312|EMBL:EDW11275.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000269|PubMed:17994087};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06441.1}
RP   IDENTIFICATION.
RX   PubMed=19011613; DOI=10.1038/nature07463;
RA   Koerich L.B., Wang X., Clark A.G., Carvalho A.B.;
RT   "Low conservation of gene content in the Drosophila Y chromosome.";
RL   Nature 456:949-951(2008).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW11275.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH933807; EDW11275.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006444; DAA06441.1; -; Genomic_DNA.
DR   RefSeq; XP_002001833.2; XM_002001797.2.
DR   AlphaFoldDB; B7FF07; -.
DR   STRING; 7230.FBpp0166280; -.
DR   GeneID; 6575829; -.
DR   KEGG; dmo:Dmoj_GI17063; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   InParanoid; B7FF07; -.
DR   ChiTaRS; WDY; fly.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50952; SSF50952; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1217
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000378997"
FT   REPEAT          155..199
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          323..362
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          366..405
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          456..495
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          508..547
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          595..635
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          740..779
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          823..862
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REGION          910..929
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1033..1217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1037..1110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1133..1179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1217 AA;  137159 MW;  31D0A5E4AD9122DD CRC64;
     MSLIYFASGD SHANIEYQTI SSTATEANQE QSERLHDRIS KAQLQRLYER FKSAPDQVVG
     CADFRRMLEE VDIVFSDFTY TRLFLKINQN HDFLVDWNEF VSYLIFGFQE EDPSSQKESL
     IMPISAAPVV RKTEHRSAVC CITLLKVKSD QTPLEDMTES ANYSFGGEDS PENSGMWVTA
     SHEGQLRFWS AHMEPLRSAV SESIYCMSYA FYNNGKTHSK LVLGDYAGNV RILSYSPYLR
     GPFQAKPGAA LVELTWADVL RGRIPLLIPK EYINLHNELI SCVYYSLHMN ALFASAEYRN
     TKKYRGRCPG LIMVSNDDRN NFRIPLGVSV FYVSEVKNIL VTGGPDTFVR IWDVYISSEP
     SAILTGHNGG IVAVFVQPEE NKVYSVDYHK IIKVWDLQEH TLLQTYGELV RIIHHSEMDI
     KYYYHSHLRE LMVAGRKLIQ VKCCPRVRVD LTDGNTHAAP VSVVLYNRLF RNIVTCGLDS
     YIIVWDPWTG RRKIIMKNCH TKMIYGETID IEITAACFDP LEQFLLTGAR DGSLKIWNYN
     NSVVVRNMSI QMDQEVTAVI WVVDRILAMG WDRQVTEFND VEGREYGDPK KWAKFHTDDI
     TCADVKLGEG VVTATYSGEI IFWKLETGQP YRRYNVMDPS QFIELKLTAE EEKLSRRSKR
     ISSLLGANRR SASMLAIKPD EIKDYGANIP VSVQAVLFLQ KRPMTKDHGS VFISLDTGII
     QVYSHHQHGG HIKEFIAVHK VGDCVLTMAT DRKNRFLYTG TAFGYIKIWH IVNYCIPEAE
     KTHVCMPKLR LDFIFLRKEL FLTRAKRMVR NQPEPMLVSS YKGHLKAINS IGFINLPKIL
     FSGSHDYSCR LWTQSGRYLG TLGTVLPWSK LSPFERAGEE NRPYRLPPDI KKVASSTTLK
     VISGVQHSFQ VKRPKPTEER EDEGEVEDTG TEMKNIFDRP LREPILGKHF ELPGRSAIEQ
     RIELDTTQLY VPIYSHLRVH PSDVMENLPT PPIIGQVKSE NYLDHYMPVV GKVDPNTSAI
     NIREPNKVIR SKAGGQVGQA RASSTWGKPK TNSILGMPRA ESSQGKARAS SAKAGVSSGY
     GRTNFGPNPS RVRSNSPKVS FMPSQLKTCR KPESSPRKAK TSPARAKSVS FPAKANPVST
     SAKANPTCTS VKTNPVPTSA KASRVSTSAK SNPVSTSANA KPDIMPVKIK PVVKKPSRNT
     APVQITTSIA KTKKDKP