ID   WDY_DROVI               Reviewed;        1182 AA.
AC   B7FF08; B4LUH8;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000303|PubMed:19011613, ECO:0000312|EMBL:DAA06442.1};
DE            Short=WD40 Y {ECO:0000303|PubMed:19011613};
GN   Name=WDY {ECO:0000312|EMBL:DAA06442.1}; ORFNames=GJ17315;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:EDW64164.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000269|PubMed:17994087};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06442.1}
RP   IDENTIFICATION.
RX   PubMed=19011613; DOI=10.1038/nature07463;
RA   Koerich L.B., Wang X., Clark A.G., Carvalho A.B.;
RT   "Low conservation of gene content in the Drosophila Y chromosome.";
RL   Nature 456:949-951(2008).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW64164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH940649; EDW64164.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006445; DAA06442.1; -; Genomic_DNA.
DR   RefSeq; XP_002052009.2; XM_002051973.2.
DR   AlphaFoldDB; B7FF08; -.
DR   STRING; 7244.FBpp0231732; -.
DR   GeneID; 6628104; -.
DR   KEGG; dvi:6628104; -.
DR   eggNOG; KOG0267; Eukaryota.
DR   eggNOG; KOG3184; Eukaryota.
DR   InParanoid; B7FF08; -.
DR   ChiTaRS; WDY; fly.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1182
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000378998"
FT   REPEAT          155..199
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          323..362
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          366..405
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          456..495
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          508..547
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          595..635
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          740..779
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          823..862
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REGION          1031..1182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1066..1088
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1097..1120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1131..1146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1182 AA;  133211 MW;  53FC9FAB002735E0 CRC64;
     MSLVYFASGD SKADIEYQTI SSTATQVSQE QSERLHDRIS KAQLQKLYEL FKSAPGQVVG
     CGDLRRMLED VDITFNDFAY TRLFLKINQN HDFMVDWNEF VSYLIFGFQE EDPSSQKEAL
     IMPISMAPVV RKTEHRSAVC CITLLKVKSD QTPMEEITES ANYSFGGEDS PENSGMWVTA
     SHEGQLRFWS AHMEPLRSAV SESIYCMSYA FYNNGKTHSK LVLGDYAGNV RILSYSPYLR
     GPFQAKPGAA LVELVWADVL RGRIPLLIPR EYINLHNELI SCVYFSLHMN TLFASAEYRN
     TKKYRGRCPG LIMVSNEDRN NFRIPLGVSV FYVSEIKNIL VTGGPDTFVR IWDVYISSEP
     SAILTGHNGG IVAVFVQPEE NKVYSVDYHK IIKVWDLQEH TLLQTYGDLV RIIHHSETDI
     KYYYHSHLRE LMVAGRKLIQ IKCCPRVRVD LTDGNTHAAP VSVVLYNRLF RNIVTCGLDS
     YIIVWDPWTG RRKIIMKNCH TKMIYGETID IEITAACFDP LEQFLLTGAR DGSLKIWNYN
     NAVVVRNMSI QPDQEVTAVI WVVDRILAMG WDRQVTEFND VEGREYGDPK KWAKFHTDDI
     TCADVKLGEG VVTATYSGEI IFWKLETGQP YRRYNVMDPS RFIELKLNAE EEKLTRRSKR
     MSSLIGVNRR STSVQAIKPD EIKDYGANIP VSVQAVLFLQ RRPMTKEHGS VFISLDTGII
     QVYSHHQHGG YIKQFTAVHK TGDCVLTMAT DRKNRFLYTG TAFGYIKVWH IVNYCIPKAE
     QTYVCMPRLR LEFIFLRKEL FLTRAKRMVR FQPEPMLVSS YKGHLKAINS IGFINLPKII
     FSGSHDYSCR LWTQGGRYLG TLGTVLPWSK LTPFERAGED NRAYRLPPDI KKVASSTTLK
     VISGIQHSFT LKRPKAAEER EEEREVEDTT TDVKNMFERP LREPILGKHF QLPGRSAIEQ
     RIELDTTQLY IPVYTHLRVY PSEMLEALPT SPIISQVKAE NYLDHYMPVV GKVDLNTSAI
     NIKEPQKLAR TKAGANLDQP RASAGWAKPK TNSILGIPRA GSSLGKARAS VSQGSPKAGV
     SSGYGKVSVS QGYPRAGSPR PCTTSLSKPK TSSSPSKPKG SFRLGSPIAA TSPANADSSP
     GKRKSSPGKR SFSPGKAKAS PGKARISSVL GKPKAKTDRE TH